DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SALL4 and CG12391

DIOPT Version :9

Sequence 1:	NP_065169.1	Gene:	SALL4 / 57167	HGNCID:	15924	Length:	1053	Species:	Homo sapiens
Sequence 2:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	372	Identity:	83/372 - (22%)
Similarity:	134/372 - (36%)	Gaps:	66/372 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   362 KPPNISAVDVKP-KDEAALYKHKCKYCS-----------KVFGTDSSLQIHLRSHTGERP----- 409
            :|.:::.|.::. |.|..:.:.:|:.|:           ::..|.:.:.:.:..:....|
  Fly   218 EPGDLADVPIRERKKEEPVDEDQCRVCTSKEELVCLFKKQIDATPADMLLVICPNVSILPKDFMP 282

Human   410 -FVCSVCGHRFTTKGNLKVHFHRHPQVKANPQ----LFAEFQDKVAAGNGIPYALSVPDPIDEPS 469
             |:|:.|      .|:|.:......|::...|    ..:..::||....|  |.:     ||.|
  Fly   283 QFICTKC------MGSLTIAIQLRKQLETTDQELRKRLSRSKNKVRRPRG--YVV-----IDAP- 333

Human   470 LSLDSKPVLVTTSVGLPQNLSSGTNPKDLTGGSLPGDLQPGPSPESEGGPTLPGV-GPNYNSPRA 533
                     ||.|......|.......|: .|:...|.....|.:||.....||. |.....|..
  Fly   334 ---------VTDSSEDEDELDDEFKVSDV-AGTTSADSDSADSDDSEKEKKKPGPRGRPRKKPLK 388

Human   534 GGFQGSGTPEPGSETLKLQQLVENIDKATTDPNECLICHRVLSCQSSLKMHYRTHTGER-PFQCK 597
            .|....|  ||.|...|..|   ....|:..|.||..|....|.:.|..:|.:||  || ...|.
  Fly   389 RGTDSDG--EPSSAQKKKYQ---PSSTASVGPFECPNCDLTFSRKQSYVLHRKTH--ERIEHACP 446

Human   598 ICGRAFSTKGNLKTHLGVHRTNTSIKTQHSCPICQKKFTNAVMLQQHI--RMHMGGQIPNTPLPE 660
            |||:.|..:...|||:..|...   :....|.:|.|.|.....|:.|:  |....|.|...
  Fly   447 ICGKKFKVEWAYKTHMQRHEQE---RAHFRCELCPKIFRLRAELKHHMAQRHDEHGFIYEC---- 504

Human   661 NPCDFTGSEPMTVGENGSTGAICHDDVIESIDVEEVSSQEAPSSSSK 707
            ..|..|......:..:.:.|...|.:  :|:.::|..|:....|.||
  Fly   505 KRCQRTFLTQQRLQRHQAVGCQRHKE--DSVRIKEEQSRFKQESRSK 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SALL4	NP_065169.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..149
		zf-C2H2	382..404	CDD:306579	3/32 (9%)
		C2H2 Zn finger	384..404	CDD:275368	3/30 (10%)
		zf-H2C2_2	396..421	CDD:316026	4/30 (13%)
		C2H2 Zn finger	412..432	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..546		15/63 (24%)
		C2H2 Zn finger	568..588	CDD:275368	5/19 (26%)
		zf-H2C2_2	580..605	CDD:316026	11/25 (44%)
		C2H2 Zn finger	596..619	CDD:275368	9/22 (41%)
		zf-C2H2	626..648	CDD:306579	7/23 (30%)
		C2H2 Zn finger	628..648	CDD:275368	7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..714		5/14 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..776
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	788..828
		C2H2 Zn finger	872..892	CDD:275368
		zf-C2H2	872..892	CDD:306579
		zf-H2C2_2	884..909	CDD:316026
		C2H2 Zn finger	900..920	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1018..1039
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	11/78 (14%)
		zf-C2H2	416..438	CDD:278523	6/21 (29%)
		C2H2 Zn finger	418..438	CDD:275368	5/19 (26%)
		zf-C2H2	443..465	CDD:278523	8/21 (38%)
		C2H2 Zn finger	445..465	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..491	CDD:275368	5/16 (31%)
		C2H2 Zn finger	504..521	CDD:275368	2/20 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910