DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SALL4 and crol

DIOPT Version :9

Sequence 1:	NP_065169.1	Gene:	SALL4 / 57167	HGNCID:	15924	Length:	1053	Species:	Homo sapiens
Sequence 2:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster

Alignment Length:	1062	Identity:	210/1062 - (19%)
Similarity:	321/1062 - (30%)	Gaps:	339/1062 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    88 LEHKKNCTKNPPVLIMNDSEGPVPSEDFSGAVLSHQPTSPGSKDCHRENGGSSEDMKEKPDAESV 152
            ::|....:..|.|:.      ||.:...:...|...|..|.|:  |:|:|        ||.....
  Fly     1 MQHVSAASSVPSVVT------PVVTTGGTTITLGGPPPLPKSE--HKEDG--------KPPHGIE 49

Human   153 VYLKTETALPPTPQDISYL-----AKGKVAN--TNVTLQALRGTKVAVNQRSADALPAPVPGANS 210
            :| |...      :|||.|     ..||:..  .|..|.|..|.:          ||.|.|
  Fly    50 MY-KVNI------EDISQLFTYHEVFGKIHGDVVNHQLAAAHGGQ----------LPPPPP---- 93

Human   211 IPWVLEQILCLQQQQLQQIQLTEQIRIQVNMWASHALHSSGAGADTLKTLGSHMSQQVSAAVALL 275
                                |..|:       .|||..::.|.|         .:...:||||.:
  Fly    94 --------------------LPPQV-------TSHAASAAAAAA---------AASTNNAAVAAV 122

Human   276 SQKAGSQGLSLDALKQAKLPHANIPSATSSLSPGLAPFTLKPDGTRVLPNVMSRLPSA------- 333
            ...|.:               |...:|.:|...||.|.|....|.:|.....|...|:
  Fly   123 MASANA---------------AAAAAAAASAGGGLPPATSGNGGQQVTVTTTSSSTSSGGSTTSG 172

Human   334 ---------LLPQAPGSVLFQSPFSTVALDTS-KKGKGKPPNIS-AVDVKPKDEAALYKHKCKYC 387
                     |:|:..|.:        ..:|.| ..|.|...|:: |.|..|   .|...|.|..|
  Fly   173 GTTTTAGELLMPKMEGGI--------HGVDGSGNGGNGGGQNVALAPDGTP---IATGTHVCDIC 226

Human   388 SKVFGTDSSLQIHLRSHTGERPFVCSVCGHRFTTKGNLKVHFHRHPQVKANPQLFA--------- 443
            .|:|.....|.:|.|.|:..:||:|.|||..|||..:|.    ||.::.....:|.
  Fly   227 GKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLT----RHGKIHIGGPMFTCIVCFNVFA 287

Human   444 -----------EFQDKVAAGNGIPYALSVPDPIDEPSLSLDSKPVLVTTSVGLPQNLSSGTNPKD 497
                       ...||       |:|.::..........||:             :..|.|
  Fly   288 NNTSLERHMKRHSTDK-------PFACTICQKTFARKEHLDN-------------HFRSHT---- 328

Human   498 LTGGSLPGDLQPGPSPESEGGPTLPGVGPNYNSPRAGGFQGSGTPEPGSETLKLQQLVENIDKAT 562
               |..|...|                   |.:               ....:.:.:|.::.|.|
  Fly   329 ---GETPFRCQ-------------------YCA---------------KTFTRKEHMVNHVRKHT 356

Human   563 TD-PNECLICHRVLSCQSSLKMHYRTHTGERPFQCKICGRAFSTKGNLKTHLGVHRTNTSIK--- 623
            .: |:.|.||.:..:.:.....||..|||:.|.||.:||:.::.|.:|..|:..|...|..:
  Fly   357 GETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEI 421

Human   624 ---------------------TQHSCPICQKKFTNAVMLQQHIRMHMGGQIPNTPLPENP--CD- 664
                                 |.|.|..|.|.||....|..|:|.|.|         |:|  |.
  Fly   422 CGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTG---------ESPHRCSY 477

Human   665 ----FTGSEPMT------VGENGSTGAIC------HDDVIESIDVEEVSSQEAPSSSSKVPTPLP 713
                ||..|.:.      .||.......|      .|.::..:      .|....|..|......
  Fly   478 CMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHV------RQHTGESPHKCTYCTK 536

Human   714 SIHSASPTLGFAMMASLDAPGKVGPAPFNLQRQGSRENGSVESDGLTNDSSSLMGDQEYQSRSPD 778
            :..............:.|:|.:.........|:          :.|||......||      ||.
  Fly   537 TFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRK----------EHLTNHVRLHTGD------SPH 585

Human   779 ILE--TTSFQALSPANSQAESIKSKSPDAGSKAESSENSRTEMEGRSSLPSTFIRAPPTYVKVEV 841
            ..|  ..:|......|:......|.:|...:........:..:....|...|..|
  Fly   586 KCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDR---------- 640

Human   842 PGTFVGPSTLSPGMTPLLAAQ-----PRRQAKQHGCTRCGKNFSSASALQIHERTHTGEKPFVCN 901
            |.|........|....||..|     .:...:...|.:|.|||.....|..|.|:|:||||..|.
  Fly   641 PFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACT 705

Human   902 ICGRAFTTKGNLKVHYMTHGANNNSARRGRKLAIENTMALLGTDGKRVSEIFPKEILAP-SVNVD 965
            :|.:||..:||||.|                :.:.:..|::...........|..:|.. ...|.
  Fly   706 LCSKAFVERGNLKRH----------------MKMNHPDAMMPPPPVHPHPQIPAGVLTQVKQEVK 754

Human   966 PVVWNQYTSMLNGGLAVKTNEISVIQ------SGGVPTLPVSLG------ATSVVNNATVSKMDG 1018
            |::...:::         |..:..||      :||...:.::.|      :|.:.:||...:...
  Fly   755 PIIIPHHSA---------TTTMHTIQQITAGAAGGAGAVQLTPGLVPLVTSTLISHNAAAQQQSQ 810

Human  1019 SQSGISADVEKPSATDGVPKHQ 1040
            .|...:|...:..|.......|
  Fly   811 KQQAAAAAAAQQQAAAAAAAQQ 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SALL4	NP_065169.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..149		9/32 (28%)
		zf-C2H2	382..404	CDD:306579	8/21 (38%)
		C2H2 Zn finger	384..404	CDD:275368	7/19 (37%)
		zf-H2C2_2	396..421	CDD:316026	11/24 (46%)
		C2H2 Zn finger	412..432	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..546		6/62 (10%)
		C2H2 Zn finger	568..588	CDD:275368	5/19 (26%)
		zf-H2C2_2	580..605	CDD:316026	10/24 (42%)
		C2H2 Zn finger	596..619	CDD:275368	7/22 (32%)
		zf-C2H2	626..648	CDD:306579	9/21 (43%)
		C2H2 Zn finger	628..648	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..714		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..776		6/39 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	788..828		4/39 (10%)
		C2H2 Zn finger	872..892	CDD:275368	8/19 (42%)
		zf-C2H2	872..892	CDD:306579	8/19 (42%)
		zf-H2C2_2	884..909	CDD:316026	12/24 (50%)
		C2H2 Zn finger	900..920	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1018..1039		3/20 (15%)
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	251..271	CDD:275368	10/23 (43%)
		C2H2 Zn finger	279..299	CDD:275368	0/19 (0%)
		COG5048	300..723	CDD:227381	105/540 (19%)
		C2H2 Zn finger	307..327	CDD:275368	2/32 (6%)
		C2H2 Zn finger	335..355	CDD:275368	3/53 (6%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	0/19 (0%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	4/19 (21%)
		C2H2 Zn finger	503..523	CDD:275368	2/25 (8%)
		C2H2 Zn finger	531..551	CDD:275368	0/19 (0%)
		C2H2 Zn finger	559..579	CDD:275368	4/29 (14%)
		C2H2 Zn finger	587..607	CDD:275368	3/19 (16%)
		C2H2 Zn finger	615..636	CDD:275368	1/20 (5%)
		C2H2 Zn finger	644..664	CDD:275368	4/19 (21%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	9/33 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910