DRSC/TRiP Functional Genomics Resources

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Protein Alignment CAMK1D and CaMKII

DIOPT Version :10

Sequence 1:NP_705718.1 Gene:CAMK1D / 57118 HGNCID:19341 Length:385 Species:Homo sapiens
Sequence 2:NP_001162833.1 Gene:CaMKII / 43828 FlyBaseID:FBgn0264607 Length:531 Species:Drosophila melanogaster


Alignment Length:327 Identity:134/327 - (40%)
Similarity:196/327 - (59%) Gaps:10/327 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENIVALED 86
            ::.||.||.||||.|....:|:||..||.|.|..|.|..:: ..:|.|..:.||:.|.|||.|.|
  Fly    14 YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHD 78

Human    87 IYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLL 151
            ..:..|:.|||..||:|||||:.||.:.||:|.|||..|:|:|::|.:.|:.|:|||||||||||
  Fly    79 SIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLL 143

Human   152 YYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILL 215
            ..|:.:.:.:.::||||: :::|.........|||||::||||.::||.|:||.|:.|||.||||
  Fly   144 LASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILL 208

Human   216 CGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIA 280
            .|||||:||:..:|:.||....|::.||.||.::..||:.|..::..:||||.|..:|.:||||.
  Fly   209 VGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWIC 273

Human   281 GDTALNKNIHESVSAQIRKNF-AKSKWRQAFNATAVVRH-------MRKLHLGSSLDSSNASVSS 337
            ....:...:|...:....|.| |:.|.:.|...|.:...       :.|...||.:..|..|.|:
  Fly   274 QRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGSQVKESTDSSST 338

Human   338 SL 339
            :|
  Fly   339 TL 340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CAMK1DNP_705718.1 STKc_CaMKI_delta 12..312 CDD:271070 126/291 (43%)
Autoinhibitory domain. /evidence=ECO:0000250 279..319 8/47 (17%)
Calmodulin-binding. /evidence=ECO:0000250 299..320 6/28 (21%)
Nuclear export signal. /evidence=ECO:0000250 318..324 1/12 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 360..385
CaMKIINP_001162833.1 STKc_CaMKII 12..303 CDD:270988 125/288 (43%)
CaMKII_AD 390..517 CDD:285524
Blue background indicates that the domain is not in the aligned region.

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