DRSC/TRiP Functional Genomics Resources

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Protein Alignment CAMK1D and CaMKI

DIOPT Version :10

Sequence 1:NP_705718.1 Gene:CAMK1D / 57118 HGNCID:19341 Length:385 Species:Homo sapiens
Sequence 2:NP_524622.1 Gene:CaMKI / 43792 FlyBaseID:FBgn0016126 Length:405 Species:Drosophila melanogaster


Alignment Length:394 Identity:228/394 - (57%)
Similarity:281/394 - (71%) Gaps:36/394 - (9%)


- Green bases have known domain annotations that are detailed below.


Human     6 GESSSSWKKQAEDIKKI---------FEFKETLGTGAFSEVVLAEEK-ATGKLFAVKCIPKKALK 60
            |:..|..|.:|:|:|::         :.....|||||||||.|||.| :.|:.||||.|.|||||
  Fly     5 GKKDSGKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALK 69

Human    61 GKESSIENEIAVLR---------------KIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRI 110
            |||.|:||||.|||               ::.|.|||.|.:.||..:.:||||:||:||||||||
  Fly    70 GKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRI 134

Human   111 VEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKG 175
            ||||.|||||||.||||:|:||.|:|..|:||||||||||||||.|::||||||||||||||..|
  Fly   135 VEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSG 199

Human   176 DVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
             :|:|||||||||||||||||||.||||.||||||:|||||||||||||||:.||.||||.::||
  Fly   200 -IMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEF 263

Human   241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSK 305
            ||||||:||:|||.||:|||.....|||||:||..|.||:|:.|.::|||.:||.|::||||||:
  Fly   264 DSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAKSR 328

Human   306 WRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPST-----LCSFISSSSGVSG 365
            |:||:.|..|:|.|:::.|.|   :|||:..||.|  |.:|...|:.     ..:.:||...|..
  Fly   329 WKQAYYAATVIRQMQRMALNS---NSNANFDSSNS--SNQDSTTPTAATGAWTSNVLSSQQSVQS 388

Human   366 VGAE 369
            ...|
  Fly   389 HAQE 392

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CAMK1DNP_705718.1 STKc_CaMKI_delta 12..312 CDD:271070 207/324 (64%)
Autoinhibitory domain. /evidence=ECO:0000250 279..319 21/39 (54%)
Calmodulin-binding. /evidence=ECO:0000250 299..320 12/20 (60%)
Nuclear export signal. /evidence=ECO:0000250 318..324 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 360..385 2/10 (20%)
CaMKINP_524622.1 STKc_CaMKI 27..301 CDD:270985 184/274 (67%)

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