Protein Alignment CAMK1D and PhKgamma

DIOPT Version :10

• Sequence 1: NP_705718.1
• Gene: CAMK1D / 57118
• HGNCID: 19341
• Length: 385
• Species: Homo sapiens
• Sequence 2: NP_511129.3
• Gene: PhKgamma / 32120
• FlyBaseID: FBgn0011754
• Length: 560
• Species: Drosophila melanogaster
• Alignment Length: 423
• Identity: 138/423 - (32%)
• Similarity: 195/423 - (46%)
• Gaps: 62/423 - (14%)

Human     1 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESS 65
            ||::..:.....|..|:.....:|.||.||.|..|.|....||.|||.||.|.|...|.  .||.
  Fly     1 MAKDEEDDLLPDKDAAKGFYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGAT--TESG 63

Human    66 IEN----------EIAVLRKIK-HENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEK 119
            ..|          ||::||::. |..|:.|:|::||...::||.:|...|||||.:......:||
  Fly    64 ETNPYHMLEATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEK 128

Human   120 DASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGT 184
            ...|::||:.:.|.|:|...||||||||||:|.   ||...:.|:|||.:|...:|:.::..|||
  Fly   129 KTRTIMRQIFEGVEYIHAKSIVHRDLKPENILL---DENHNVKITDFGFAKQLQEGEKLTNLCGT 190

Human   185 PGYVAPEVL------AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSP 243
            |||:|||.|      ....||:.||.|:.|||.:.||.|.|||:......:...|::.:|.|.||
  Fly   191 PGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSP 255

Human   244 YWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHES---VSAQIRKNFAKSK 305
            .|.|||:..||.||..:..||::|.|.::..|||:......:....|.:   ..||...
  Fly   256 EWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPIAPAQTNS------ 314

Human   306 WRQAFNATAVVRHMRKLHLGS----SLDSSNASVSSSLSLASQKD---------------CLAPS 351
                       ||:.:....|    .|:||.|...:.|..|.|..               ..|.|
  Fly   315 -----------RHLLQPEASSYRFGQLNSSCAGAPNYLYCAPQSSYSSNRMRDGALDDAGASAAS 368

Human   352 TLCSFISSSSGVSGVGAERRPRPTTVTAVHSGS 384
            ..| .:.|.|..|...|......|:.:|:.|.|
  Fly   369 ATC-HVMSPSNASNSYATNTTANTSNSALASAS 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAMK1D	NP_705718.1	STKc_CaMKI_delta	12..312	CDD:271070	115/319 (36%)
		Autoinhibitory domain. /evidence=ECO:0000250	279..319		4/42 (10%)
		Calmodulin-binding. /evidence=ECO:0000250	299..320		2/20 (10%)
		Nuclear export signal. /evidence=ECO:0000250	318..324		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..385		7/25 (28%)
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	110/276 (40%)