Protein Alignment MAPK3 and rl

DIOPT Version :9

• Sequence 1: NP_002737.2
• Gene: MAPK3 / 5595
• HGNCID: 6877
• Length: 379
• Species: Homo sapiens
• Sequence 2: NP_001015122.1
• Gene: rl / 3354888
• FlyBaseID: FBgn0003256
• Length: 376
• Species: Drosophila melanogaster
• Alignment Length: 372
• Identity: 284/372 - (76%)
• Similarity: 314/372 - (84%)
• Gaps: 11/372 - (2%)

Human     2 AAAAAQGGGGGEPRRTEGVGPGVP-GEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRK 65
            :.:...|.|..|          || ...|:::||.|:|||||.:|.||||||||||.||.|.:..
  Fly     7 SGSVVNGTGSTE----------VPQSNAEVIRGQIFEVGPRYIKLAYIGEGAYGMVVSADDTLTN 61

Human    66 TRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLY 130
            .|||||||||||||||||||||||.||.||:|||:|.||||||..:::.||||||||.|||||||
  Fly    62 QRVAIKKISPFEHQTYCQRTLREITILTRFKHENIIDIRDILRVDSIDQMRDVYIVQCLMETDLY 126

Human   131 KLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH 195
            ||||:|:||||||||||||||||||||||||||||||||||||:|.|||||||||||||||||||
  Fly   127 KLLKTQRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEH 191

Human   196 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGI 260
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:
  Fly   192 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGV 256

Human   261 LGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325
            |||||::||.||||.||||||:|||.|..|.||||||.:|:.|||||.:||||||:|||.|||||
  Fly   257 LGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEAL 321

Human   326 AHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQ 372
            |||||||||||.||||||.||...||.||:.::.||.|||:||.:|:
  Fly   322 AHPYLEQYYDPGDEPVAEVPFRINMENDDISRDALKSLIFEETLKFK 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK3	NP_002737.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		5/24 (21%)
		STKc_ERK1_2_like	36..370	CDD:270839	275/333 (83%)
		TXY	202..204		1/1 (100%)
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	275/333 (83%)
		S_TKc	38..326	CDD:214567	243/287 (85%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	507	1.000	Domainoid score	I328
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	591	1.000	Inparanoid score	I988
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D309855at33208
OrthoFinder	1	1.000	-	-		FOG0000164
OrthoInspector	1	1.000	-	-		otm41796
orthoMCL	1	0.900	-	-		OOG6_100339
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X259
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.830