Protein Alignment atp8b4 and CG33298

DIOPT Version :10

• Sequence 1: XP_687715.4
• Gene: atp8b4 / 559291
• ZFINID: ZDB-GENE-121116-7
• Length: 1214
• Species: Danio rerio
• Sequence 2: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Alignment Length: 1377
• Identity: 430/1377 - (31%)
• Similarity: 658/1377 - (47%)
• Gaps: 275/1377 - (19%)

Zfish     8 ETLRTRRR-----WPGVMAIWKKDVHIE-------EERHVR-----------ANDRDY-NERFSY 48
            |::.|.||     |      ||:.....       |||..|           ...||: |.:|
  Fly   194 ESIYTLRRTEAPPW------WKRLTLCNYNTGDKFEERSYRTVVPNHTVPPKTPKRDHPNGQF-- 250

Zfish    49 ADNRIKTAKYNVFTFLPINLFEQFQRFANAYFLVLLILQLIPEISSLSWFTTIVPLVLVLAITAV 113
            ..|:|:|.||.:.:|:|.||.|||.|.||.||:.:::|..:||||:......::|::.||.:|||
  Fly   251 VGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAV 315

Zfish   114 KDATDDYFRHKSDQQVNTRQSQVLIKG---KLQNEKWMNVRVGDVIKLENNQFVAADLLLLSSSE 175
            ||..:|..|..||:::|....:| ..|   :.:..||..:||||::.|.||:.|.||:|||.:|:
  Fly   316 KDLFEDRRRRASDKRINNTTCRV-YDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSD 379

Zfish   176 PYGLCYIETAELDGETNLKVRQALTVTSDLGDDVAKLADFNGEVICEPPNNKLDKFIGTL-YWKD 239
            |.|:|||:|.:||||||||.|:.:....:: ..:...:.|...|..:.|..||.:|.|.| :...
  Fly   380 PQGVCYIDTCDLDGETNLKRREVVRGFEEM-QSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTG 443

Zfish   240 NKYPLDNEKMLLRGCVLRNTEWCFGLVIFAGLQTKLMQNCGRTKFKRTSIDKLMNTLVLWIFGFL 304
            .:.|:..|.:|||...|:||::..|:|::||.:||.|.|....::||:.:::.||..|:|....|
  Fly   444 ERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIIL 508

Zfish   305 ICMGIILAIGNTIWEQSVGSDFWAYLQWKELTVNAVFSGFLTFWSYIIILNTVVPISLYVSVEVL 369
            :.:.::.|||..:|..|.......||...:||.|  ......||:||:||..::|:||||::|:.
  Fly   509 LILCVVGAIGCRMWLSSFTHFPVPYLPPNKLTAN--MESMWIFWTYIVILQVMIPLSLYVTIELC 571

Zfish   370 RLGHSYFINWDRRMYYSRKDTPAEARTTTLNEELGQVEFIFSDKTGTLTQNIMVFNKCSINGKTY 434
            ::...:.|:.:..::.:..:...|.|...:.|||||::.||:|||||||:|.|:|.:|.:||..|
  Fly   572 KILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDY 636

Zfish   435 GDVFDEFGHKVDITEKTPCVDFSFNPLMDRKFRFHD-SSLVEAIKL--EEPLVQEFFRLLALCHT 496
            .....|. .|:......|.     .||:.......| :.|.:...|  ....:|||..:||:|:|
  Fly   637 NHPPSEL-EKIYSKPGAPA-----PPLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNT 695

Zfish   497 VM--------------------------------------------------------------- 498
            |:
  Fly   696 VIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSI 760

Zfish   499 ------------------------------------------------------PEERN------ 503
                                                                  |..:|
  Fly   761 PADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNS 825

Zfish   504 ---------------------------------------------EGELVYQAQSPDEGALVTAA 523
                                                         :|..:|:|:||||.|||.||
  Fly   826 ISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAA 890

Zfish   524 RNFGFVFRSRTPETITLYEM---GQAVTYQLLAILDFNNVRKRMSVIVRNPKGQ-LKLYSKGADT 584
            .::.....:|:|..| |..|   |....|::|.:|.|::.||.||::||....| :.||:||||:
  Fly   891 YSYDCCLLNRSPNQI-LVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADS 954

Zfish   585 ILFDRLDPSNEE-----LMFTTSEHLNEFAGEGLRTLALAYKDLDEDVFDEWTKKLLFASTALDN 644
            .:...|.|.:..     |...|.:.|:.:|.||||.|.:|.:.|:...:.:|..:......:|:|
  Fly   955 SIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLEN 1019

Zfish   645 REEKLGALYEEIEQGMMLLGATAIEDKLQEGVPETIACLTLANIKIWVLTGDKLETAMNIGYSCN 709
            ||.:|...:.::|..:.|||||.|||:||:|||||||.|..|.|.:|||||||.|||:||.||..
  Fly  1020 RERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAK 1084

Zfish   710 MLRDDMNEVFIISGHTMLEVQQELRTAKERIMGPSKDKFSSGL-----DMEKTELYSVDSVFEET 769
            :....|..:                    |:...|:|...:.:     |||..:..|.....:..
  Fly  1085 LFTQQMELI--------------------RLTARSRDAAETAINFYLTDMENDKTTSTLGYGQSL 1129

Zfish   770 IIAEYALIINGHSLAHALEAELEQIL--VDVACLCKSVICCRVTPLQKALVVELIKRHKRAVTLA 832
            ...:.||:::|.:|...|:.:.:.||  :.::..|.||:|||.||||||.:|:::|......|||
  Fly  1130 RKKQRALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLA 1194

Zfish   833 IGDGANDVSMIKTAHIGVGISGQEGMQAVLASDYSFAQFRYLQRLLLVHGRWSYHRMCNFLCYFF 897
            |||||||||||:.|.:|||||||||||||:|:|::..:||||:||||.||.|.|.|:...:.|||
  Fly  1195 IGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFF 1259

Zfish   898 YKNFAFTLVHFWYGFLCGFSAQTVYDQWFITLFNIVYTSLPVLAMGLFDQDVNEQYSLRYPNLYR 962
            |||.||..:.|||...||||.|.:.||.::.|:|:::||||.||:|::|:.|.|...|:.|.||:
  Fly  1260 YKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYK 1324

Zfish   963 PGQLNQLFNKRKFFTCTLQGVYTSFILFFIPYGAFMPAVRDDGAQISDQQAFAVTIATSLVIVVS 1027
            .|:|...:....|:...|..:|.|.::||:...|:  |..|.|.     ..|..||..|.:....
  Fly  1325 NGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAY--AESDVGI-----WEFGTTITASCLFANL 1382

Zfish  1028 VQIGLDTNYWTAVNHFFIWGSLAVY--FAILF---AMNSNGIFTIFPNQFPFIGSARNSLNQKIV 1087
            |...::...||.::...|..||..:  |||::   .||..|:.:.:...|....||       :.
  Fly  1383 VHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASA-------VH 1440

Zfish  1088 WLVILLNTVVCIMPMLAVRFIKTDLYPTHTDKVRLLQQATRRQRPQEQNLRRVRRTSSRRSAYAF 1152
            ||||:|:|||.::|.|.:..::..|.|..:.|| :||....|.| .|..|....|::|..|.|..
  Fly  1441 WLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKV-ILQSKRERSR-GEALLVTWSRSTSASSIYRI 1503

Zfish  1153 SHQQGYGELITS 1164
            :......::||:
  Fly  1504 TDYGSKNQIITT 1515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
atp8b4	XP_687715.4	P-type_ATPase_APLT_Dnf-like	50..993	CDD:319770	366/1133 (32%)
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	366/1133 (32%)