DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC39A4 and Catsup

DIOPT Version :9

Sequence 1:	NP_570901.3	Gene:	SLC39A4 / 55630	HGNCID:	17129	Length:	647	Species:	Homo sapiens
Sequence 2:	NP_524931.1	Gene:	Catsup / 48805	FlyBaseID:	FBgn0002022	Length:	449	Species:	Drosophila melanogaster

Alignment Length:	358	Identity:	109/358 - (30%)
Similarity:	160/358 - (44%)	Gaps:	74/358 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   311 SQSRPPVQDQLSQSERYLYGSLATLLICLCAVFGLLLLTCTGCRGVTHYILQTFLSLAVGAVTGD 375
            ::::|    .|..|..:|:...:||||. .|.|.||.:............|:..|:.|.|.:.||
  Fly   120 TKAKP----DLDMSTIWLHSIGSTLLIS-AAPFVLLYIIPLDNSEAMKPRLKVLLAFASGGLLGD 179

Human   376 AVLHLTPKVLGLHTHSEEG-----------------------LSPQPTWRLLAMLAGLYAFFLFE 417
            |.|||.|.....|:|.|.|                       :|..     |.:|.|:.||...|
  Fly   180 AFLHLIPHATHPHSHGEHGHDHGHDHHHHHDGEEHEHGHSHDMSIG-----LWVLGGIIAFLSVE 239

Human   418 NLFNLLLPRDPEDLEDGPCGHSSHSHGGHSHGVSLQLAPSELRQPKP-PHEGSRADLVAEES--- 478
            .|..:|           ..||..|   |||||     ||    :||| |.:...:|  .|:|
  Fly   240 KLVRIL-----------KGGHGGH---GHSHG-----AP----KPKPVPAKKKSSD--KEDSGDG 279

Human   479 -----PELLNPEPRRLSP--ELRLLPYMITLGDAVHNFADGLAVGAAFASSWKTGLATSLAVFCH 536
                 |..:..:.....|  |:.:..|:....|..|||.||||:||::.:....|:.|::.:..|
  Fly   280 DKPAKPAKIKSKKPEAEPEGEVEISGYLNLAADFAHNFTDGLAIGASYLAGNSIGIVTTITILLH 344

Human   537 ELPHELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVA-LAVGVSEESEAWILAVATGLFLYV 600
            |:|||:||||.|:.:|.|.|:|:||.|.:||.|.||..:| |..|..:.|..|:|....|.|:|:
  Fly   345 EVPHEIGDFAILIKSGCSRRKAMLLQLVTALGALAGTALALLGAGGGDGSAPWVLPFTAGGFIYI 409

Human   601 ALCDMLPAML----KVRDPRPWLLFLLHNVGLL 629
            |...:||.:|    |::.....:..||..|.|:
  Fly   410 ATVSVLPELLEESTKLKQSLKEIFALLTGVALM 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC39A4	NP_570901.3	ZIP4_domain	46..196	CDD:375719
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..255
		Zip	328..638	CDD:308248	106/341 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..486		8/36 (22%)
Catsup	NP_524931.1	Zip	129..446	CDD:280666	107/345 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D657777at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820