DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC39A4 and Zip99C

DIOPT Version :9

Sequence 1:	NP_570901.3	Gene:	SLC39A4 / 55630	HGNCID:	17129	Length:	647	Species:	Homo sapiens
Sequence 2:	NP_001189313.1	Gene:	Zip99C / 43533	FlyBaseID:	FBgn0039714	Length:	355	Species:	Drosophila melanogaster

Alignment Length:	350	Identity:	98/350 - (28%)
Similarity:	156/350 - (44%)	Gaps:	74/350 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   327 YLYGSLATLLICLCAVFGLLLLTCTGCRGVTHY-------ILQTFLSLAVGAVTGDAVLHLTPKV 384
            :::..|.:::|.|..:|.|:::..........|       :|:..||.|||.:.||..|||.|:
  Fly    36 WVFSLLGSVVIGLSGIFPLIIIPTEEKMAKEGYKDPADSKLLRVLLSFAVGGLLGDVFLHLLPE- 99

Human   385 LGLHTHSEEGLSPQPT---------WRLLAMLAGLYAFFLFENLFNLLLPRD-----PEDLEDGP 435
                  :.||.:..|:         |    :|:|:..|.:.|.:|:.....|     |:.:|...
  Fly   100 ------AWEGDNQDPSSHPSLRSGLW----VLSGILIFTIVEKIFSGYASADEENPQPKCVEIAN 154

Human   436 CGHSSHSHGGHSHGVSLQLAPSELRQPKPPHEGSRADL----------VAEESPELLNPEPRRLS 490
            |  ....|||       ||...|..:..    |...|:          ..|:..:....:|::::
  Fly   155 C--LLRRHGG-------QLPEGETSESC----GGACDIEDVGKVCFLREQEQKSKERKEQPKKVA 206

Human   491 PELRLLPYMITLGDAVHNFADGLAVGAAFASSWKTGLATSLAVFCHELPHELGDFAALLHAGLSV 555
            ..|.|      |.:::.||..||||..:|..|::.|:..:.|:..||:|||:||||.||.:|.|.
  Fly   207 GYLNL------LANSIDNFTHGLAVAGSFLVSFRHGILATFAILLHEIPHEVGDFAILLRSGFSR 265

Human   556 RQALLLNLASALTAFAGLYVALAV----GVSEESEA---WILAVATGLFLYVALCDMLPAMLKVR 613
            ..|.   .|..|||.|||..||..    ||:...||   ||:....|.||::||..:||.:||..
  Fly   266 WDAA---RAQLLTAGAGLLGALVAIGGSGVTSAMEARTSWIMPFTAGGFLHIALVTVLPDLLKEE 327

Human   614 DPR---PWLLFLLHNVGLLGGWTVL 635
            :.:   ..||.|:..:.|:...|:|
  Fly   328 ERKESIKQLLALVFGIALMAVMTML 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC39A4	NP_570901.3	ZIP4_domain	46..196	CDD:375719
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..255
		Zip	328..638	CDD:308248	97/348 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..486		4/37 (11%)
Zip99C	NP_001189313.1	Zip	34..350	CDD:280666	96/346 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D657777at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820