Protein Alignment SLC39A4 and Zip71B

DIOPT Version :10

• Sequence 1: NP_570901.3
• Gene: SLC39A4 / 55630
• HGNCID: 17129
• Length: 647
• Species: Homo sapiens
• Sequence 2: NP_001097608.1
• Gene: Zip71B / 39626
• FlyBaseID: FBgn0036461
• Length: 572
• Species: Drosophila melanogaster
• Alignment Length: 590
• Identity: 172/590 - (29%)
• Similarity: 258/590 - (43%)
• Gaps: 183/590 - (31%)

Human   196 FHALP-SPQY--FVDFVFQQHSSEVPMTLAELSALMQRLGVGR----EAHSDHSHRHRGASSRDP 253
            |..:| |.:|  :|..:||::.:...:....|..||..|.:|:    .:|:...||.:|.|:..|
  Fly    19 FKTVPASTEYNKYVAQIFQKYGNGGTINFEGLEHLMFSLNLGQIQFDPSHTIDQHRPQGYSNEMP 83

Human   254 --------------------------VPLISSSNSSS---------VWD-------------TVC 270
                                      .|..:.|||.|         :.|             ..|
  Fly    84 HATNVTYYFEPTRVNATDEEALELQISPRGNHSNSQSEAEVPEFLEIHDPKHRHPRESSEPVAAC 148

Human   271 LSAR-------------------------DVMAAYGL--SEQ--------AGVTPEAWAQLSPAL 300
            ||.:                         ||.:..|:  ||:        ..:||.|:.:|.|||
  Fly   149 LSPKSLLSLIVNHNDLHKNIAYRKLLIKNDVSSTDGVHNSEEEYNEFINSVRITPRAFMKLCPAL 213

Human   301 LQQQLSGACTSQSRPPVQD-QLSQSER-----YLYGSLATLLICLCAVFGLLLLTCTGCRGVTHY 359
            |.|..:|.|   .:|.|:. .|:...:     ::|.|:..|::..|.:.|:||:..........
  Fly   214 LAQIDNGVC---KQPAVRSVNLNDKNQKIWYAWIYASITMLILSACGLLGILLVPLMKSAAYQE- 274

Human   360 ILQTFLSLAVGAVTGDAVLHLTP-----------KVLGL------HTHSEEGLSPQPTWRLLAML 407
            ||:..:|:|||.:.|||::||.|           :|.|:      |.||.|.          |:|
  Fly   275 ILKFLVSIAVGTLAGDALMHLLPHALFKEEKHEEEVTGINPLESDHKHSNEA----------ALL 329

Human   408 AG---LYAFFLF--ENLFNLLLPRDPEDLEDGPCGHSSHSHG-GHSHGVSLQLAPSELRQPKPPH 466
            .|   |.|.|::  |||..|        |:.|..|| .|||| |||||.|
  Fly   330 CGCTFLAALFMYMLENLIPL--------LKGGKPGH-GHSHGHGHSHGRS--------------- 370

Human   467 EGSRADLVAEESPELLNPEPRRL------------SPELRLLP--YMITLGDAVHNFADGLAVGA 517
            .|......|:::.:|  |.||.|            :|:..|.|  :|:.:||.:||..||||:||
  Fly   371 HGHMEKPAAKDAIDL--PPPRELNVMLQEAKLDEKTPDRPLTPVAFMVIIGDGLHNLTDGLAIGA 433

Human   518 AFASSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVALAV-GV 581
            ||||...||.||:.||.||||||||||||.||..|:|:|:|:.:|:.|::.:|.|:.|.|.: |:
  Fly   434 AFASDPVTGFATAFAVLCHELPHELGDFALLLQTGVSMRRAVYMNIVSSVLSFVGMSVGLFIAGI 498

Human   582 SEESEAWILAVATGLFLYVALCDMLPAML------KVRDPRPWLLFLLHNVGLLGGWTVLLLLSL 640
            .:....||.|...|.|||:|..|::|.|.      |.:||:.   .::...|:|.|..::|.::|
  Fly   499 GDGMTQWIYAATAGSFLYIAFADLVPTMSVAHNPEKAKDPKG---IIIQIFGILLGGLIMLAIAL 560

Human   641 YEDDI 645
            .|.|:
  Fly   561 NEHDL 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC39A4	NP_570901.3	ZIP4_domain	46..196	CDD:465698	172/590 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	236..255		6/44 (14%)
		Zip	328..638	CDD:396884	123/353 (35%)
		Essential for SLC39A4 endocytosis. /evidence=ECO:0000269|PubMed:32348750	452..454		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	458..484		3/25 (12%)
Zip71B	NP_001097608.1	Zip	242..559	CDD:396884	123/356 (35%)