DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC39A4 and Zip48C

DIOPT Version :9

Sequence 1:	NP_570901.3	Gene:	SLC39A4 / 55630	HGNCID:	17129	Length:	647	Species:	Homo sapiens
Sequence 2:	NP_610712.1	Gene:	Zip48C / 36273	FlyBaseID:	FBgn0033665	Length:	341	Species:	Drosophila melanogaster

Alignment Length:	352	Identity:	75/352 - (21%)
Similarity:	129/352 - (36%)	Gaps:	96/352 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   274 RDVMAAYGLSEQAGVTPEAWAQLSPALLQQQLSGACTSQSRPPVQDQLSQSERYLYGSLATLLIC 338
            |.:.||.|.:....:....|:.|.||:                   ::::|. :|||..|.|.:.
  Fly    38 RSLDAALGFAAGVMIAASFWSLLKPAI-------------------EMAESS-HLYGVYAFLPVA 82

Human   339 LCAVFGLLLLTCTGCRGVTHYILQTFLSLAVGAVTGDAVLHLTPKV----LGLHTHSEEGLSPQP 399
            ...:.|.:.:  .||..:..|:         |..:.:.::.:|...    :.:......|::|
  Fly    83 GGFLLGSIFV--YGCDKLMSYL---------GLNSTNMMIQMTQSKAKADIAIEDSKRNGVAP-- 134

Human   400 TWRLLAMLAGLYAFFLFENLFNLLLPRDPEDLEDGPCGHSSHSHGGHSH----GVSLQLAPSELR 460
                                 :.|..:..:...|  |  .|..|.|.|.    |.|:    :|:.
  Fly   135 ---------------------DRLASKSLDSFSD--C--LSVQHSGESRRRKKGASI----NEME 170

Human   461 Q--PKPPHEGSRADLVAEESPELLNPEPRRLSPELRLLPYMITLGDAVHNFADGLAVGAAFASSW 523
            |  ...|.|..||:       :.|:...|     :.||...||    |||..:|||||.:|.:..
  Fly   171 QCTYTTPEEQQRAE-------DALSQWKR-----IMLLVVAIT----VHNIPEGLAVGVSFGAIG 219

Human   524 KTGLAT-------SLAVFCHELPHELGDFAALLHAGLSVRQALLL-NLASALTAFAGLYVALAVG 580
            .|..:|       ::.:.....|..|.....|..||.||::||.. .|:..:....|:..|:||.
  Fly   220 STNSSTFESARNLAIGIGIQNFPEGLAVSLPLHAAGFSVKRALWYGQLSGMVEPIFGVLGAVAVT 284

Human   581 VSEESEAWILAVATGLFLYVALCDMLP 607
            .:.....:.|:.|.|..:|:...|:||
  Fly   285 FANLILPYALSFAAGAMIYIVSDDILP 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC39A4	NP_570901.3	ZIP4_domain	46..196	CDD:375719
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..255
		Zip	328..638	CDD:308248	66/298 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..486		7/29 (24%)
Zip48C	NP_610712.1	ZupT	23..340	CDD:223505	75/352 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810