DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC39A4 and Zip42C.2

DIOPT Version :9

Sequence 1:	NP_570901.3	Gene:	SLC39A4 / 55630	HGNCID:	17129	Length:	647	Species:	Homo sapiens
Sequence 2:	NP_610231.2	Gene:	Zip42C.2 / 35580	FlyBaseID:	FBgn0033097	Length:	310	Species:	Drosophila melanogaster

Alignment Length:	312	Identity:	60/312 - (19%)
Similarity:	112/312 - (35%)	Gaps:	95/312 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   339 LCAVFGLLLLTCTGCRGVTHYILQTF--------------------LSLAVGAVTGDAVLHLTPK 383
            :.|:..|.|:|...|  ...|:|..|                    |:...|.:.....:|:.|:
  Fly    11 IVAIVVLFLVTLIFC--FIPYLLDRFYKWTQRPENNAREFKVVLCLLNFGGGVLIATTFIHMLPE 73

Human   384 VLGLHTHSEEGLSPQPTWRLLA----------MLAGLYAFFLFENLFNLLLPRDPEDLEDGPCGH 438
            |:       |.::.....|:||          :..|.|..:..|...:.::.|..:
  Fly    74 VV-------EVVNALQDCRMLAPTPFGLPEVLLCTGFYLMYCIEETMHFVVRRRQQ--------- 122

Human   439 SSHSHGGHSHGVSLQLAPSELRQP---KPPHEGSRADLVA--EESPELLNPEPRRLSPELRLLPY 498
                              .:||:.   |...|..|.::|.  ||||:    ||.    .||.|..
  Fly   123 ------------------RKLREVVTIKDAGEELRTEIVVQPEESPK----EPN----WLRGLGI 161

Human   499 MITLGDAVHNFADGLAVGAAFASS--W-KTGLATSLAVFCHE--LPHELGDFAALLHAG--LSVR 556
            ::.|  ::|....|:|:|...:.|  | .||     |:..|:  |...:|....:.|..  |:|.
  Fly   162 IVAL--SLHELFGGMAIGLEMSVSTVWFMTG-----AISVHKLVLAFCIGMEIMMAHTRWLLAVV 219

Human   557 QALLLNLASALTAFAGLYVALAVGVSEES--EAWILAVATGLFLYVALCDML 606
            ..|:.::.:.:....|:.|:.:...::.|  ...:..:|.|..:||...:::
  Fly   220 YLLVFSIVTPIGVGIGIAVSESAAANQPSTVSGILQGLACGTLIYVVFFEIV 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC39A4	NP_570901.3	ZIP4_domain	46..196	CDD:375719
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..255
		Zip	328..638	CDD:308248	60/312 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..486		10/32 (31%)
Zip42C.2	NP_610231.2	Zip	9..294	CDD:280666	60/312 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910