Protein Alignment PRKAA1 and CG4629

DIOPT Version :10

• Sequence 1: NP_996790.3
• Gene: PRKAA1 / 5562
• HGNCID: 9376
• Length: 574
• Species: Homo sapiens
• Sequence 2: NP_608564.3
• Gene: CG4629 / 33284
• FlyBaseID: FBgn0031299
• Length: 570
• Species: Drosophila melanogaster
• Alignment Length: 537
• Identity: 144/537 - (26%)
• Similarity: 241/537 - (44%)
• Gaps: 104/537 - (19%)

Human    20 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLD--VVGKIRREIQNLKLF 82
            || :||.|.....:|.|.|.|||:..|:||..|||:|:::..: ..||  .:..:..||..|:..
  Fly    60 GR-RIGLYRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVVDLDR-AGLDAKALRMLSSEIATLECV 122

Human    83 RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQ 147
            .||:|::|::|:.|...:::|.|::.||||:::|.:.|               .|.|..:..|.:
  Fly   123 HHPNILRLFEVVETLGRVYLVTEWIRGGELYNHITQGG---------------PLREIHAAPLLK 172

Human   148 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG--EFLRTSCGSPNYAAPEV 210
            |:|..|.:.|....||||:|.|||||.:....|:||||.|..:.:|  :.|.|.||||.|||||:
  Fly   173 QLLLAVKHMHSLGYVHRDIKAENVLLLSEDRLKLADFGFSTQLINGANQKLDTFCGSPPYAAPEL 237

Human   211 ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHML 275
            .|...|.|..||:|:.|::||.::.|.:||....:|.|...|..|.:..|..|:...|.|::.:|
  Fly   238 FSDDHYIGAPVDVWALGILLYFMVVGNMPFRAPTIPGLKAAILKGDYLLPGQLSLPCIRLIQRIL 302

Human   276 QVDPMKRATIKDIREHEW----------FKQDLPKYLFPEDPSY------------SSTMIDDEA 318
            ...|.:|.||.|:...::          .:.::.::..|...|.            |:::.|..|
  Fly   303 IHIPAQRPTIDDMLNSQFVTCPKLSADLMQWEINQHTKPVKRSIFWVRSKSHRLRKSASLRDRYA 367

Human   319 LKEVCEKFECS-----EEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLD 378
              ||.:|...|     ::|    ::.:|...|:.:.:.|::.....:.|.:....|..|
  Fly   368 --EVVKKPAISMNTRQQDE----MFVQNFLQPIEMGHELLVPVSSQLKEPQSTEQAKRP------ 420

Human   379 DHHLTRPHPERVPFLVAETPRARHTLDELNPQK---SKHQGVRKAK---WHLGIRSQSRPNDIMA 437
                ||      .::...:.:.:.|..|..|:|   :..|.:..||   |::.:          |
  Fly   421 ----TR------RYMFCGSLKKKVTPMETEPEKQLANGGQSIGSAKINPWNVEV----------A 465

Human   438 EVCRAIKQLDYEWK--VVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAK 500
            |.|...|..|.|..  |:.|           |:|.....|...:.::|..|.:.....:.:..|:
  Fly   466 EDCPLFKNYDAETGSCVMLP-----------TNTEDLSQLGALEFEARQILAELGLTSEMLINAR 519

Human   501 -SGTATPQRSGSVSNYR 516
             ||    .||..:..||
  Fly   520 QSG----PRSDIIGAYR 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKAA1	NP_996790.3	STKc_AMPK_alpha	24..294	CDD:270981	96/283 (34%)
		UBA_AID_AAPK1	311..375	CDD:270586	13/68 (19%)
		AMPKA1_C	419..572	CDD:213384	23/104 (22%)
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	96/273 (35%)