DRSC/TRiP Functional Genomics Resources

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Protein Alignment PRKAA1 and Sik2

DIOPT Version :10

Sequence 1:NP_996790.3 Gene:PRKAA1 / 5562 HGNCID:9376 Length:574 Species:Homo sapiens
Sequence 2:NP_569972.1 Gene:Sik2 / 31170 FlyBaseID:FBgn0025625 Length:1398 Species:Drosophila melanogaster


Alignment Length:415 Identity:151/415 - (36%)
Similarity:232/415 - (55%) Gaps:43/415 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    22 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86
            :::|.|.:..|:|.|.|..||:.:|.:|.::||:||:::.::...: :.|:.||::.:|..:|||
  Fly   136 MRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTN-LQKVYREVEIMKRLKHPH 199

Human    87 IIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILS 151
            |||||||:.|.:.|::|.||.|.||:||||.|.||.|               |..:|..|.||:|
  Fly   200 IIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMS---------------ESAARFKFWQIIS 249

Human   152 GVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 216
            .|:|||:..:||||||.||:|||.:||.||||||.||....||.|.|.||||.||||||..|:.|
  Fly   250 AVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQY 314

Human   217 AGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMK 281
            .|||:||||.||:||.|:||.||||...:.:|..::..|.|..|.:::.....|::.||.::|.:
  Fly   315 TGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTR 379

Human   282 RATIKDIREHEWFKQDL------PKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNR 340
            |.||..|:.|.|...:|      .||....: ..:|....::.|:.:.|......::..:.| .:
  Fly   380 RYTIDQIKRHRWMCPELLEHVLIAKYNLGAE-RQTSVEPSEDILRIMAEYVGIGSDKTRASL-KK 442

Human   341 NHQDPLAVAYHLIIDNRRIMNEAKD------FYLATSPPDSFL-----DDHHLTRPHPERVPFLV 394
            |..|.:|..|.|:.|  |:.::.:.      ..||:|...|.:     :||..|:...::    .
  Fly   443 NTYDHVAAIYLLLQD--RVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQ----Q 501

Human   395 AETPRARHTL--DELNPQKSKHQGV 417
            ::|......|  |:.:.:.|:||.|
  Fly   502 SKTISTSSILAKDQCHKRLSRHQTV 526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PRKAA1NP_996790.3 STKc_AMPK_alpha 24..294 CDD:270981 122/269 (45%)
UBA_AID_AAPK1 311..375 CDD:270586 14/69 (20%)
AMPKA1_C 419..572 CDD:213384
Sik2NP_569972.1 STKc_SIK 140..392 CDD:270973 121/267 (45%)
UBA_SIK 418..458 CDD:270523 9/42 (21%)
Blue background indicates that the domain is not in the aligned region.

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