Protein Alignment Atp8b2 and CG33298

DIOPT Version :10

• Sequence 1: NP_001355579.1
• Gene: Atp8b2 / 54667
• MGIID: 1859660
• Length: 1209
• Species: Mus musculus
• Sequence 2: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Alignment Length: 1330
• Identity: 423/1330 - (31%)
• Similarity: 660/1330 - (49%)
• Gaps: 256/1330 - (19%)

Mouse    13 RAGAPPSWSQK---KPSWGTE-EERRARA----------NDREYNEKFQYASNCIKTSKYNIVTF 63
            |..|||.|.:.   ..:.|.: |||..|.          ..:..:...|:..|.|:|:||.:::|
  Fly   201 RTEAPPWWKRLTLCNYNTGDKFEERSYRTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSF 265

Mouse    64 LPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQ 128
            :|.||.|||..|||.||:|:::|..:|:||:......::|::.||.:|||||..:|..|..||.:
  Fly   266 IPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKR 330

Mouse   129 VNNRHSQVLINGVLQ---QEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGE 190
            :||...:| .:|..:   :.:|..:.||||:.|.||:.|.||:|||.:|:|.|:|||:|.:||||
  Fly   331 INNTTCRV-YDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGE 394

Mouse   191 TNMKVRQAIPVTSELGDVSQLARFDGEVICEPPNNKLDKFSGTL-YWKENKFPLSNQNMLLRGCV 254
            ||:|.|:.:....|:..:...::|...|..:.|..||.:|.|.| :....:.|:|.:.:|||...
  Fly   395 TNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESR 459

Mouse   255 LRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVCMGVILAIGNAIWEH 319
            |:||::..|:|::||.:||.|.|:...::||:.:::.||..|:|....|:.:.|:.|||..:|..
  Fly   460 LKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLS 524

Mouse   320 EVGTRFQV-YLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMF 383
            .. |.|.| |||.::.  :|.......||:||:||..::|:||||::|:.::...:.|:.:..:|
  Fly   525 SF-THFPVPYLPPNKL--TANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLF 586

Mouse   384 CMKKRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGHSYGDVFDVLGHKAELGE 448
            ..:.....|.|...:.|||||:::||:|||||||:|.|:|.:|.:||..|......|........
  Fly   587 DAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPG 651

Mouse   449 RPEPVDFSFNPLADKKFLFWDSSLLEAVKMGDPHT---HEFFRLLSLCHTVM------------- 497
            .|.|      ||.....|..|.:.|.......||.   .||..:|::|:||:
  Fly   652 APAP------PLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNAS 710

Mouse   498 ----------------------------------------------------------------- 497
                                                                             
  Fly   711 GIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVT 775

Mouse   498 ----------------------------------SEE-----KNE-------------------- 503
                                              ||.     ||:
  Fly   776 PSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKI 840

Mouse   504 -----------------------GELY--------YKAQSPDEGALVTAARNFGFVFRSRTPKTI 537
                                   |.:|        |:|:||||.|||.||.::.....:|:|..|
  Fly   841 TSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQI 905

Mouse   538 TVH--ELGTAITYQLLAILDFNNIRKRMSVIVRN-PEGKIRLYCKGADTILLDRLHP-----PTQ 594
            .|.  ..|....|::|.:|.|::.||.||::||. ...:|.||.||||:.::..|.|     |..
  Fly   906 LVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEG 970

Mouse   595 ELLSSTTDHLNEYAGDGLRTLVLAYKDLDEEYYEEWARRRLQASLAQDSREDRLASIYEEVESDM 659
            .|...|...|:.||.:|||.||:|.:.|:...|.:|..|..:..::.::||.||...:.::||::
  Fly   971 ILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNL 1035

Mouse   660 MLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFVVTGHT 724
            .|||||.|||:||.|||||||.|..|.|.:|||||||.|||:||.||.|:.|..|
  Fly  1036 TLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQM---------- 1090

Mouse   725 VLEVREELRKARKKMVDSSHAVGNGFTYQGNLSSSKLTSVL----EAVAGEYALVINGHSLAHAL 785
                  ||.:...:..|::....|  .|..::.:.|.||.|    .....:.|||::|.:|...|
  Fly  1091 ------ELIRLTARSRDAAETAIN--FYLTDMENDKTTSTLGYGQSLRKKQRALVVDGKTLTFIL 1147

Mouse   786 E--ADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAHIGV 848
            :  :.:.|.||..:..|.:|:|||.||||||.:|::||:.....||||||||||||||:.|.:||
  Fly  1148 DPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGV 1212

Mouse   849 GISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFCG 913
            |||||||:|||:|:|::..:|::|:||||.||.|.|.|:.:.:.||||||.||..:.||:..:||
  Fly  1213 GISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCG 1277

Mouse   914 FSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICIA 978
            ||.|.:.||.::.|||:::||||.||:||:|:.|.|...::.|.||:.|:|.:.:...:|::.:.
  Fly  1278 FSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILL 1342

Mouse   979 QGIYTSVLMFFIPYGVFAEATRDDGTQLADYQSFAVTVATSLVIVVSVQIGLDTGYWTAINHFFI 1043
            ..:|.|:::||:....:||:  |.|     ...|..|:..|.:....|...::...||.::...|
  Fly  1343 DALYQSLVIFFVALCAYAES--DVG-----IWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSI 1400

Mouse  1044 WGSLAVY--FAILF---AMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIALTTAVCIMPVVAF 1103
            ..||..:  |||::   .|:..|:...:...|....:|.:       ||.|.|:|.|.::|.:..
  Fly  1401 VLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVH-------WLVIMLSTVVAVLPRLLL 1458

Mouse  1104 RFLRLSLKPDLSDTVRYTQLVRKKQKAQHR 1133
            ..:|:||.||.|     |:::.:.::.:.|
  Fly  1459 TTVRISLCPDDS-----TKVILQSKRERSR 1483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atp8b2	NP_001355579.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	12..36		9/26 (35%)
		P-type_ATPase_APLT_Dnf-like	50..991	CDD:319770	377/1130 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1179..1209
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	377/1130 (33%)