Protein Alignment pins and Gpsm1

DIOPT Version :10

• Sequence 1: NP_524999.2
• Gene: pins / 53569
• FlyBaseID: FBgn0040080
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: XP_006233732.1
• Gene: Gpsm1 / 246254
• RGDID: 628682
• Length: 705
• Species: Rattus norvegicus
• Alignment Length: 671
• Identity: 312/671 - (46%)
• Similarity: 412/671 - (61%)
• Gaps: 127/671 - (18%)

  Fly    43 CLELALEGERLCKAGDCRAGVAFFQAAIQAGTEDLRTLSAIYSQLGNAYFYLGDYNKAMQYHKHD 107
            ||||||||||||||||.:||||||:||:|.|||||:||||||||||||||||.:|.:|:|:||||
  Rat    60 CLELALEGERLCKAGDFKAGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEYARALQFHKHD 124

  Fly   108 LTLAKSMNDRLGEAKSSGNLGNTLKVMGRFDEAAICCERHLTLARQLGDRLSEGRALYNLGNVYH 172
            |.||:::.||:||||:||||||||||:||||||.:||:|||.:|::.||::.|.|||||:|||||
  Rat   125 LLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQGDKVGEARALYNIGNVYH 189

  Fly   173 AKGKHL---GQRNPGKFGDDVKEALTRAVEFYQENLKLMRDLGDRGAQGRACGNLGNTYYLLGDF 234
            ||||.|   ..::||....||:|.|.||.|||:.||.|:::||||.|||||.||||||:||||:|
  Rat   190 AKGKQLSWNAAQDPGHLPPDVRETLHRASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNF 254

  Fly   235 QAAIEHHQERLRIAREFGDRAAERRANSNLGNSHIFLGQFEDAAEHYKRTLALAVELGEREVEAQ 299
            ..|...|:|||.||:||||:||||||.|||||:|||||:|:.||||||:||.|:.:|.::.||||
  Rat   255 TEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQ 319

  Fly   300 SCYSLGNTYTLLHEFNTAIEYHNRHLAIAQELGDRIGEARACWSLGNAHSAIGGHERALKYAEQH 364
            :|||||||||||.::..|.|||.|||.|||||.||:||.|||||||||:.::|...:||.:|::|
  Rat   320 ACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADRVGEGRACWSLGNAYVSMGSPAQALTFAKKH 384

  Fly   365 LQLAKELHDPVGESTARVNISDLRKLLGMPDSEPSPTEEEARSTASDHSASGNQSDGSENSQGRM 429
            ||:::|:.|..||.|||:||:.|:..||...| |:..|:.        ..:|.::.|:     |.
  Rat   385 LQISQEIGDRNGELTARMNIAHLQLALGRLTS-PAAAEKP--------DLAGYEAQGA-----RP 435

  Fly   430 VRVRRQSMEQLDLIKITPD--------------------------GKRMQE-------------- 454
            .|.:|.|.|..||:::..|                          .::.||
  Rat   436 KRTQRLSAETWDLLRLPLDREQNGETHHTGDWRGPSRDSLPLPMRSRKYQEGPDAIERRPREGSH 500

  Fly   455 -----EKLRAQATR----KAKDDD---FFEMLSRSQSKRMDDQRCSIKVNPAGAPAVATGATRKP 507
                 ..:|.|..|    :|...|   ||::||:.||.|||||||.::...|||.......|.:.
  Rat   501 SPLDSADVRVQVPRTGIPRAPSSDEECFFDLLSKFQSSRMDDQRCPLEEGQAGAAEATAAPTLEE 565

  Fly   508 LVQQNSLFVDPT------------------------NLPGLKSPSSANPSAIGHGPLARSATTTQ 548
            ...|.|:...|.                        :||||:    ...:.:||   .|.....|
  Rat   566 RAAQPSVTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLR----ITLNNVGH---LRGDGDPQ 623

  Fly   549 QPDDDFLDMLMRCQGSRLEEQRSELPRPNVTMDAEAEAPPRSVPEAAVPGAPRGQTGRGATVPDE 613
            :|.|:|.:||::.|.||:::||.              .||..:|             ||.|:|||
  Rat   624 EPGDEFFNMLIKYQSSRIDDQRC--------------PPPDVLP-------------RGPTMPDE 661

  Fly   614 DFFSLIMKVQSGRMEDQRASI 634
            ||||||.:||:.||::||..:
  Rat   662 DFFSLIQRVQAKRMDEQRVDL 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pins	NP_524999.2	TPR	50..261	CDD:440225	145/213 (68%)
		TPR repeat	83..109	CDD:276809	19/25 (76%)
		TPR repeat	120..150	CDD:276809	24/29 (83%)
		TPR	162..>373	CDD:440225	135/213 (63%)
		TPR repeat	162..199	CDD:276809	23/39 (59%)
		TPR repeat	219..246	CDD:276809	17/26 (65%)
		TPR repeat	251..291	CDD:276809	29/39 (74%)
		TPR repeat	296..326	CDD:276809	21/29 (72%)
		TPR repeat	338..366	CDD:276809	14/27 (52%)
		GoLoco	468..488	CDD:460481	13/22 (59%)
		GoLoco	552..573	CDD:460481	9/20 (45%)
		GoLoco	613..633	CDD:460481	13/19 (68%)
Gpsm1	XP_006233732.1	TPR repeat	63..88	CDD:276809	21/24 (88%)
		TPR repeat	100..126	CDD:276809	19/25 (76%)
		TPR	101..354	CDD:440225	166/252 (66%)
		TPR repeat	137..167	CDD:276809	24/29 (83%)
		TPR repeat	239..266	CDD:276809	17/26 (65%)
		TPR repeat	271..307	CDD:276809	28/35 (80%)
		TPR repeat	318..345	CDD:276809	18/26 (69%)
		TPR_12	322..390	CDD:315987	42/67 (63%)
		TPR repeat	352..386	CDD:276809	18/33 (55%)
		GoLoco	526..547	CDD:460481	13/20 (65%)
		GoLoco	579..599	CDD:460481	0/19 (0%)
		GoLoco	627..647	CDD:460481	9/33 (27%)
		GoLoco	661..682	CDD:460481	13/20 (65%)