DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment larp and SRO9

DIOPT Version :9

Sequence 1:	NP_001247347.1	Gene:	larp / 53567	FlyBaseID:	FBgn0261618	Length:	1673	Species:	Drosophila melanogaster
Sequence 2:	NP_009893.2	Gene:	SRO9 / 850320	SGDID:	S000000542	Length:	434	Species:	Saccharomyces cerevisiae

Alignment Length:	548	Identity:	116/548 - (21%)
Similarity:	187/548 - (34%)	Gaps:	184/548 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 AAAVPAATTETATTTTVDASQADALAKVVVKDKKKVNQKASDFSNVGDW---PTLIGGTSGSGK- 425
            :|...||.|.||....|...::        ...|:||...:.......|   ||.|..::.|.:
Yeast     2 SAETAAANTATAPVPEVQEQES--------SKSKQVNLTPAPLPTSSPWKLAPTEIPVSTISIED 58

  Fly   426 --ATSNEPKRNPTKKQQSAKTAAAVAASSNTTSSEVATESNVAGTTSSSNSNPSSSTTTTNTTTN 488
              ||..:..|.||.|..:|.....:.||...:.::.:...|.|   |:.|||.|.:..|..::|:
Yeast    59 LDATRKKKNRTPTPKSSTATKWVPIKASITVSGTKRSGSKNGA---SNGNSNKSKNNKTAASSTS 120

  Fly   489 SQATTAPVASTSHDAKAQRD-AEPAANSAAGTTGTAAGPALTKKIPKHKWRPLPIDLAKSSRPKP 552
            |...........|:||.|:. .:....||.|.                       :.:|.:..:.
Yeast   121 SSNANRKKKHHQHNAKKQQQMKKDGFESAVGE-----------------------EDSKDATSQE 162

  Fly   553 IGGRPNRRFSDDIADQRRPPRVYHDRQPGAGGAGVESRHPHAGRHPYGSRPATATSERVDSWRSS 617
            .|         ....|::||   |.|           .|.|:..|                  :|
Yeast   163 NG---------QSTQQQQPP---HHR-----------NHHHSHHH------------------NS 186

  Fly   618 SSTTTAAFDEQRSGAAGGAGAAGTGVGSATRGPRRYRTPYRGGRQGRGG------------FSRQ 670
            :......|  ..|..||.....|.        |.::: ||: ||..|..            .::|
Yeast   187 NGPQRRKF--HNSNNAGMPQNQGF--------PPQFK-PYQ-GRNARNNNNNRSKYHNHFHHNQQ 239

  Fly   671 GPGRPTYRIPRHLLASGEYANYLPADAAGADSQSSYVLMGTHYFGNVPAAYIELDANSIKEAIKK 735
            .|.:|..::.:         .:.|...         |||..:                   .|.:
Yeast   240 HPQQPMVKLQQ---------QFYPVQP---------VLMAIN-------------------NIAR 267

  Fly   736 QVEYYFSVDNLTGDFFLRRKMDPEGYIPVTLIASFHRVL----------------------ALTT 778
            |:|||||.:|||.|.:||.|:..:|:.|::||:.|:||:                      |.|.
Yeast   268 QIEYYFSEENLTVDNYLRSKLSKDGFAPLSLISKFYRVVNMSFGGDTNLILAALREIVANEAATV 332

  Fly   779 DVAVIVNAIKESDKL-------ELFEGYKVRTKTTPTTWPITEVPEVNEGEPKAIG--------- 827
            :||....|.||.|.:       ...:.|.||:|:.....|.|...|:|. |.:.:|
Yeast   333 NVAEGTLAAKEGDNVTGEAKEPSPLDKYFVRSKSWSNWLPETFETEINI-EKELVGDALDQFMIS 396

  Fly   828 --TLEQEQLEQNDGQEKLEEQTEADSPP 853
              .:.|::.|.:......|::|:.||.|
Yeast   397 LPPVPQQEEESSTELASQEQETKEDSAP 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
larp	NP_001247347.1	LARP_1_2	730..803	CDD:153403	31/101 (31%)
		DM15	1341..1382	CDD:128927
		DM15	1383..1421	CDD:128927
SRO9	NP_009893.2	LHP1	1..434	CDD:227520	116/548 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I2862
eggNOG	1	0.900	-	-		E1_COG5193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001290
OrthoInspector	1	1.000	-	-		mtm9176
orthoMCL	1	0.900	-	-		OOG6_103868
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1945
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930