DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment larp and Larp1

DIOPT Version :10

Sequence 1:NP_733244.5 Gene:larp / 53567 FlyBaseID:FBgn0261618 Length:1673 Species:Drosophila melanogaster
Sequence 2:NP_082727.1 Gene:Larp1 / 73158 MGIID:1890165 Length:1072 Species:Mus musculus


Alignment Length:1487 Identity:449/1487 - (30%)
Similarity:591/1487 - (39%) Gaps:520/1487 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   134 ARKEKPRDQQPAGGRGDGQKPQQAGGRRV------PGSSDTERKSVRPRAPRGGSPRKSAAGAAG 192
            |||:...|.|...|.|||......|.||.      ||....||:|.||                 
Mouse    24 ARKKPAPDAQAESGPGDGGGEPDGGVRRPRPACARPGRDGAERESPRP----------------- 71

  Fly   193 AAGSNAGAVSSAVPGGPKVHKDRKDTSPSASIEGAGSSGNEAKSADGDQQAGEKGAAGAAPPPKR 257
                                       |:|:...|||.|.:....|                   
Mouse    72 ---------------------------PAAAEAPAGSDGEDGGRRD------------------- 90

  Fly   258 FIAAPPPKVNAWKISAKQSGSPKAGTSPLDKRVLQPKAQQQQQQTKQTASQNNNAQNTASNKKTQ 322
            |:.|||||||.|   .|.:..|.|                                       ..
Mouse    91 FVEAPPPKVNPW---TKHAPPPAA---------------------------------------VN 113

  Fly   323 QQQQPQQGATTTTQTTTAAAAAATAAAAATAATTSAAAATSSAAAVPAATTETATTTTVDASQAD 387
            .|..|:                           .||.|....|||                    
Mouse   114 GQPPPE---------------------------PSAPAKVVRAAA-------------------- 131

  Fly   388 ALAKVVVKDKKKVNQKASDFSNVGDWPT--LIGGTSGSGKATSNEPKRN-PTKKQQSAKTAAAVA 449
                    .|.:...|..||.:..:|||  .|...|...::...:|.|. |.||..         
Mouse   132 --------PKPRKGSKVGDFGDAVNWPTPGEIAHKSVQPQSHKPQPARKLPPKKDM--------- 179

  Fly   450 ASSNTTSSEVATESNVAGTTSSSNSNPSSSTTTTNTTTNSQATTAPVASTSHDAKAQRDAEPAAN 514
                        :....|..|.|..:|.:.:..:....|.            |...||..:    
Mouse   180 ------------KEQEKGDGSDSKESPKTKSDESGEEKNG------------DEDCQRGGQ---- 216

  Fly   515 SAAGTTGTAAGPALTKKIPKHKWRPLPIDLAKSSRPKPIGGRPNRRFSDDIADQRRPPRVYHDRQ 579
                          .||..||||.||.||:......:.:..||.|            |:      
Mouse   217 --------------KKKGSKHKWVPLQIDMKPEVPREKLASRPTR------------PQ------ 249

  Fly   580 PGAGGAGVESRHPHAGR-HPYGSRPAT----ATSERVDSWRSSSSTTTAAFDEQRSGAAGGAGAA 639
                    |.||..|.| ...||.|||    :.:....:|:..:....|..|:..:.:....||.
Mouse   250 --------EPRHTPAVRGEMKGSEPATYMPVSVAPPTPAWQPETKVEPAWHDQDETSSVKSDGAG 306

  Fly   640 GTGVGSATRGPRRYRTPYRGGRQGRGGFSRQGPGRPTYRIPRHLLASGEYA-NYLPADAAGADSQ 703
            |.            |..:||..:|||    :|.||.......|.    :|. .|...|.......
Mouse   307 GA------------RASFRGRGRGRG----RGRGRGRGGTRTHF----DYQFGYRKFDGTEGPRT 351

  Fly   704 SSYVLMGTHYFGNVPAAYI-ELDANSIKEAIKKQVEYYFSVDNLTGDFFLRRKMDPEGYIPVTLI 767
            ..|:...|:||.||.:..| .:|...:|:.||:|:|||||||||..|||||||||.:|::|:|||
Mouse   352 HKYMNNITYYFDNVSSNEIYSMDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLI 416

  Fly   768 ASFHRVLALTTDVAVIVNAIKESDKLELFEGYKVRTKTTPTTWPITEVPEVNEGEPKAIGTLEQE 832
            ||||||.|||||:::|..|:|:|..:|:.| .|||.:..|..||:...|.|:             
Mouse   417 ASFHRVQALTTDISLIFAALKDSKVVEMVE-EKVRRREEPEKWPLPGPPIVD------------- 467

  Fly   833 QLEQNDGQEKLEEQTEADSPPPILTSAMATKPLNSIPPPPMPRNPQNLVPKMLQDKQQSRSSTIA 897
             ..|.|..:.|                                |....||     :|..:..|.:
Mouse   468 -YSQTDFSQLL--------------------------------NCPEFVP-----RQHYQKETES 494

  Fly   898 ALNSVNAISALTQQVEGGAAELAGHLSGLAESVKPKSTSTPDKRNAASAGNGAGSAAALVAEPEG 962
            |..|..|::.:..:.|        .:|.|....|..|.|.||..:.:                  
Mouse   495 APGSPRAVTPVPTKTE--------EVSNLKTLPKGLSASLPDLDSES------------------ 533

  Fly   963 IWKEVKRRSKTNAIKENATTPPQQQQPPLSQTLNNNNDNVKTNNTSSKSKSSSNNAPSNASSSAT 1027
             |.|||:|.:.:..:     |.:.::|                                      
Mouse   534 -WIEVKKRPRPSPAR-----PKKPEEP-------------------------------------- 554

  Fly  1028 VCVTTNNASSATKATTKTTTTSTATTTTNNNIKSGNAAYSKTHSKSSSKTAAP---PSAQCHA-- 1087
                                                        :.|..||.|   ||.|..:  
Mouse   555 --------------------------------------------RFSHPTALPQQLPSQQLMSKD 575

  Fly  1088 --EKEELDFQFDEEL--MDPLPPGTGRINNFTENFSDDDESDYEFADRDINKLLIVAQVGRAP-- 1146
              |:|||||.||||:  ||      ||.|.||. :|::| ||||..|||:||:|||.|.  .|  
Mouse   576 QDEQEELDFLFDEEMEQMD------GRKNTFTA-WSEED-SDYEIDDRDVNKILIVTQT--PPYM 630

  Fly  1147 -KHEGYDRTADFTSRTKITQDLENIINDGLVNYEEDLWT---------TTNVVADYKTVNVISQA 1201
             :|.|.|||.:.|||.|::.:|..:|||||..||:||||         ....|.::|.||:||:.
Mouse   631 RRHPGGDRTGNHTSRAKMSAELAKVINDGLFYYEQDLWTEKFEPEYSQIKQEVENFKKVNMISRE 695

  Fly  1202 DFEKLAGGRNKSVLPPQVVPP-PPPFEEDLDETLVG-------DTTLNSTLNNTL---------- 1248
            .|:.|.  ....|.|.|.||| ||.|::...:.|..       .:|:..:|..|:          
Mouse   696 QFDTLT--PEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNAR 758

  Fly  1249 ------------KSRRARFY-AAPNSHSIDPRTPRKRKLRHTANPPVEAHVGWLLDTVEHRPRTT 1300
                        .|:..||| ......::|.:.|||||.||::|||:|:||||::|:.||||||.
Mouse   759 TPRTPRTPQLKDSSQTPRFYPVVKEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSREHRPRTA 823

  Fly  1301 SMGS--SAGTSPTASSYGSFGSSVPQSLPVFQHPSHALLKENNFTQQAYHKYHSRCLKERRRLGY 1363
            |:.|  |.|| |...|||    ..|||||.||||||.|||||.|||..||||..|||.||:|||.
Mouse   824 SISSSPSEGT-PAVGSYG----CTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGI 883

  Fly  1364 GQSQEMNTLYRFWSFFLRENFNKSMYNEFRSLALEDAGNGFRYGLECLFRFFSYGLEKKFRPNIY 1428
            |||||||||:||||||||::|||.||.||:.||||||..|:|||||||||::|||||||||.:|:
Mouse   884 GQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIF 948

  Fly  1429 QDFQDETIADYETGQLYGLEKFWAFLKYYKNGEKLEVQPKLAEYLKSFKNIEDFRVVEPEINEML 1493
            :|||:||:.|||.|||||||||||||||.| .:.|::.|||.|||..|:.:|||| |:|.:.|  
Mouse   949 KDFQEETVKDYEAGQLYGLEKFWAFLKYSK-AKNLDIDPKLQEYLGKFRRLEDFR-VDPPMGE-- 1009

  Fly  1494 QGVGSLNP----GRQLNRHRSVSESDGTAVIAAGGRRLNTTITNRSDYVGRLLQQQH 1546
            :|....:|    |....|.|..|:|....  |.|..:..||.|.::.........||
Mouse  1010 EGNHKRHPVVAGGSGEGRKRCPSQSSSRP--ATGISQPPTTPTGQATREDAKWTSQH 1064

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
larpNP_733244.5 LARP_1_2 730..803 CDD:153403 46/72 (64%)
DM15 1341..1382 CDD:128927 31/40 (78%)
DM15 1383..1421 CDD:128927 27/37 (73%)
Larp1NP_082727.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..268 90/480 (19%)
PRK12323 <2..>194 CDD:481241 63/350 (18%)
Required for interaction with PABPC1. /evidence=ECO:0000250|UniProtKB:Q6PKG0 70..550 179/820 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 289..331 14/57 (25%)
LHP1 <349..533 CDD:227520 79/243 (33%)
LARP_1_2 379..451 CDD:153403 46/72 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..578 26/203 (13%)
Required for interaction with RPTOR and for repression of mRNAs with a 5'TOP motif. /evidence=ECO:0000250|UniProtKB:Q6PKG0 551..1072 253/619 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 737..773 3/35 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 790..837 28/47 (60%)
Interaction with mRNA. /evidence=ECO:0000250|UniProtKB:Q6PKG0 850..1000 107/150 (71%)
DM15 862..902 CDD:128927 31/39 (79%)
DM15 903..941 CDD:128927 27/37 (73%)
Interaction with 7-methylguanosine mRNA cap structure. /evidence=ECO:0000250|UniProtKB:Q6PKG0 933..976 32/42 (76%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1003..1072 17/66 (26%)

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