DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment larp and LARP1B

DIOPT Version :9

Sequence 1:	NP_001247347.1	Gene:	larp / 53567	FlyBaseID:	FBgn0261618	Length:	1673	Species:	Drosophila melanogaster
Sequence 2:	XP_016863827.1	Gene:	LARP1B / 55132	HGNCID:	24704	Length:	1143	Species:	Homo sapiens

Alignment Length:	1481	Identity:	428/1481 - (28%)
Similarity:	572/1481 - (38%)	Gaps:	516/1481 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 AGGRRVPGSSDTERKSVRPRAPR---------------GGSPRKSAAGAAGAAGSNAGAV----- 201
            |..|..|.:...||:|:...|.|               ....|.:||.:|||.|..:.|:
Human    10 AHSREDPPAVTAERESLLAAANRPAEQPPPPECEGKEAAREERAAAATSAGARGEPSPALVLGRS 74

  Fly   202 --SSAVPGGP----KVHKDRKDTSPSASIEGAGSSGNEAKSADGDQQAGEKGAAGAAPPPKRFIA 260
              .:|||..|    ..||.|                            |..|..|..|||
Human    75 VPQAAVPVRPLALHLAHKAR----------------------------GPGGPFGGEPPP----- 106

  Fly   261 APPPKVNAWKISAKQSGSPKAGTSPLDKRVLQPKAQQQQQQTKQTASQNNNAQNTASNKKTQQQQ 325
             |||.                 .|||...:..|.|:..:::.....::           |.|...
Human   107 -PPPP-----------------PSPLPPLLRDPPAEDAREEVAAGPAE-----------KRQPPL 142

  Fly   326 QPQQGATTTTQTTTAAAAAATAAAAATAATTSAAAATSSAAAVPAATTETATTTTVDASQADALA 390
            .|.:|...|.:.....:...|........|..|               |..:...:.|.
Human   143 LPPKGNPWTKKPPQHLSPDTTGPPPPPLETLEA---------------EFGSLKIIKAG------ 186

  Fly   391 KVVVKDKKKVNQKASDFSNVGDWPT---LIGGTSGSGKATSNEPKRNPTKKQQSAKTAAAVAASS 452
                |.|.|.:.||||||::.:|||   |:  .:|.....|...|:...:|::..|    |...|
Human   187 ----KLKTKKSNKASDFSDMENWPTPSELV--NTGFQSVLSQGNKKPQNRKEKEEK----VEKRS 241

  Fly   453 NTTSSE-VATESNVAGTTSSSNSNPSSSTTTTNTTTNSQATTAPVASTSHDAKAQRDAEPAANSA 516
            |:.|.| ..|:.|..|...|.:...||:                          ||
Human   242 NSDSKENRETKLNGPGENVSEDEAQSSN--------------------------QR--------- 271

  Fly   517 AGTTGTAAGPALTKKIPKHKWRPLPIDLAKSSRPKPIGGRPNRRFSDDIADQRRPPRVYHDRQPG 581
                         |:..||||.||.:|:.:|.                  .|.||
Human   272 -------------KRANKHKWVPLHLDVVRSE------------------SQERP---------- 295

  Fly   582 AGGAGVESR-HPHAGRHPYGSRPATATSERVD--SWRSSSSTTTAAFDEQRSGAAGGAGAAGTGV 643
              |:...|| .|.|.:..:.:|       |.|  ||:..........|.....:.||
Human   296 --GSRNSSRCQPEANKPTHNNR-------RNDTRSWKRDREKRDDQDDVSSVRSEGG-------- 343

  Fly   644 GSATRGPRRYRTPYRGGRQGRGGFSRQGPGRP------TYRIPRHLLASGEYANYLPADAAGADS 702
                    ..|..:||..:|||....:|.|.|      :|....|    ||..:. |.......|
Human   344 --------NIRGSFRGRGRGRGRGRGRGRGNPRLNFDYSYGYQEH----GERTDQ-PFQTELNTS 395

  Fly   703 QSSYVLMGTHYFGNVPAAYIELDANSIKEAIKKQVEYYFSVDNLTGDFFLRRKMDPEGYIPVTLI 767
            ...|      |..........::...:||.||:|:||||||:||..|||||.|||.:|::|::||
Human   396 MMYY------YDDGTGVQVYPVEEALLKEYIKRQIEYYFSVENLERDFFLRGKMDEQGFLPISLI 454

  Fly   768 ASFHRVLALTTDVAVIVNAIKESDKLELFEGYKVRTKTTPTTWPITEVPEVNEGEPKAIGTLEQE 832
            |.|.||.||||::.:|:.|:|:|.::|:.: .|:|.|..|..|||...|      |:::...:..
Human   455 AGFQRVQALTTNLNLILEALKDSTEVEIVD-EKMRKKIEPEKWPIPGPP------PRSVPPTDFS 512

  Fly   833 QLEQNDGQEKLEEQTEADSPPPILTSAMATKPLNSIPPPPMPRNPQNLVPKMLQDKQQSRSSTIA 897
            ||              .|.|..:...|..:. ..|.|..|...:|       |..|:.|.:|.:.
Human   513 QL--------------IDCPEFVPGQAFCSH-TESAPNSPRIGSP-------LSPKKNSETSILQ 555

  Fly   898 ALNSVNAISALTQQVEGGAAELAGHLSGLAESVKPKSTSTPDKRNAASAGNGAGSAAALVAEPEG 962
            |::                       .||       |||.||                |.:||
Human   556 AMS-----------------------RGL-------STSLPD----------------LDSEP-- 572

  Fly   963 IWKEVKRRSKTNAIK--ENATTPPQQQQPPLSQTLNNNNDNVKTNNTSSKSKSSSNNAPSNASSS 1025
             |.|||:|.:...:|  |:.:.|                       ..|.::..|:..|
Human   573 -WIEVKKRHQPAPVKLRESVSVP-----------------------EGSLNQLCSSEEP------ 607

  Fly  1026 ATVCVTTNNASSATKATTKTTTTSTATTTTNNNIKSGNAAYSKTHSKSSSKTAAPPSAQCHAEKE 1090
                                                                          |:|
Human   608 --------------------------------------------------------------EQE 610

  Fly  1091 ELDFQFDEELMDPLPPGTGRINNFTENFSDDDESDYEFADRDINKLLIVAQV-GRAPKHEGYDRT 1154
            ||||.||||:..     .||.|.||: :||:| ||||..|:|:||:|||.|. ....||.|.|||
Human   611 ELDFLFDEEIEQ-----IGRKNTFTD-WSDND-SDYEIDDQDLNKILIVTQTPPYVKKHPGGDRT 668

  Fly  1155 ADFTSRTKITQDLENIINDGLVNYEEDLW---------TTTNVVADYKTVNVISQADFEKLAGGR 1210
            ....||.|||.:|..:|||||..||:|||         .....|.::|.:|:||:..||.|.  .
Human   669 GTHMSRAKITSELAKVINDGLYYYEQDLWMEEDENKHTAIKQEVENFKKLNLISKEQFENLT--P 731

  Fly  1211 NKSVLPPQVVPPPPP---------------------------------------------FEEDL 1230
            .....|.|.||..|.                                             ..::|
Human   732 ELPFEPNQEVPVAPSQSRQEECWRHKMSWRCSRSASHSQERIIILVTVKKMDWERKWQMYLTDEL 796

  Fly  1231 DETLVGDTTLNSTL-----------------NNTLKSRRA----------RFY-AAPNSHSIDPR 1267
            .:.|...:.:.|..                 ..|.|:.|.          ||| ......:||.:
Human   797 AQKLFDVSEITSAAMVHSLPTAVPESPRIHPTRTPKTPRTPRLQDPNKTPRFYPVVKEPKAIDVK 861

  Fly  1268 TPRKRKLRHTANPPVEAHVGWLLDTVEHRPRTTSMGSSAGT----SPTASSYGSFGSSVPQSLPV 1328
            :|||||.||:.|||:|.||||::|:.:..|.|:|:.:|..:    :|.|.|||    ..|.|.|.
Human   862 SPRKRKTRHSTNPPLECHVGWVMDSRDRGPGTSSVSTSNASPSEGAPLAGSYG----CTPHSFPK 922

  Fly  1329 FQHPSHALLKENNFTQQAYHKYHSRCLKERRRLGYGQSQEMNTLYRFWSFFLRENFNKSMYNEFR 1393
            ||||||.|||||.||||.||||..|||.||:|||.|||||||||:||||||||::|||.||.|||
Human   923 FQHPSHELLKENGFTQQVYHKYRRRCLSERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFR 987

  Fly  1394 SLALEDAGNGFRYGLECLFRFFSYGLEKKFRPNIYQDFQDETIADYETGQLYGLEKFWAFLKYYK 1458
            .||.|||...:||||||||||:|||||||||..|:||||:||..|||:|||||||||||:|| |.
Human   988 QLAWEDAKENYRYGLECLFRFYSYGLEKKFRREIFQDFQEETKKDYESGQLYGLEKFWAYLK-YS 1051

  Fly  1459 NGEKLEVQPKLAEYLKSFKNIEDFRVVEPEINEMLQGVGSLNPGRQLNRHR 1509
            ..:...:.|||.|||.|||.:|||||..|..:|..:...|...|.:.||||
Human  1052 QSKTQSIDPKLQEYLCSFKRLEDFRVDPPISDEFGRKRHSSTSGEESNRHR 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
larp	NP_001247347.1	LARP_1_2	730..803	CDD:153403	39/72 (54%)
		DM15	1341..1382	CDD:128927	32/40 (80%)
		DM15	1383..1421	CDD:128927	27/37 (73%)
LARP1B	XP_016863827.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151758
Domainoid	1	1.000	383	1.000	Domainoid score	I827
eggNOG	1	0.900	-	-		E1_COG5193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1136
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258488at2759
OrthoFinder	1	1.000	-	-		FOG0001290
OrthoInspector	1	1.000	-	-		otm40535
orthoMCL	1	0.900	-	-		OOG6_103868
Panther	1	1.100	-	-	O	PTHR22792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1945
SonicParanoid	1	1.000	-	-		X2271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790