Protein Alignment: larp and LARP1

• Sequence 1: NP_001247347.1
• Gene: larp
• FlyBaseID: FBgn0261618
• Length: 1673
• Species: Drosophila melanogaster
• Sequence 2: NP_291029.2
• Gene: LARP1
• HGNCID: 29531
• Length: 1096
• Species: Homo sapiens
• Alignment Length: 1455
• Identity: 446/1456 (31%)
• Similarity: 587/1456 (40%)
• Gaps: 506/1456 (35%)

  Fly   146 GGRGDGQKPQQAGGRRVPGSSDTERKSVRPRAPRGGSPRKSAAGAAGAAGSNAGAVSSAVPGGPK 210
            ||....:.|....|:..||.:|.          |||.|              .|:.....|...|
Human    22 GGLVRKKPPPAPEGKGEPGPNDV----------RGGEP--------------DGSARRPRPPCAK 62

  Fly   211 VHKDRKDTSPSASIEGAGSSGNEAKS------------ADGDQQAGEK----GAAGAAPPPKR-F 258
            .||           ||.|....|:..            :||::..||.    ||||||...:| |
Human    63 PHK-----------EGTGQQERESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGRRDF 116

  Fly   259 IAAPPPKVNAWKISAKQSGSPKAGTSPLDKRVLQPKAQQQQQQTKQTASQNNNAQNTASNKKTQQ 323
            :.|||||||.|                 .|..|.|..                        .|..
Human   117 VEAPPPKVNPW-----------------TKNALPPVL------------------------TTVN 140

  Fly   324 QQQPQQGATTTTQTTTAAAAAATAAAAATAATTSAAAATSSAAAVPAATTETATTTTVDASQADA 388
            .|.|.:                           .:|.|....||||
Human   141 GQSPPE---------------------------HSAPAKVVRAAVP------------------- 159

  Fly   389 LAKVVVKDKKKVNQKASDFSNVGDWPTLIGGTSGSGKATSNEPKRNPTKKQQSAKTAAAVAASSN 453
                    |::...|..||.:..:|||.......|.:..|::|:  ||:|....|.
Human   160 --------KQRKGSKVGDFGDAINWPTPGEIAHKSVQPQSHKPQ--PTRKLPPKKD--------- 205

  Fly   454 TTSSEVATESNVAGTTSSSNSNPSSSTTTTNTTTNSQATTAPVASTSHDAKAQRDAEPAANSAAG 518
                   .:....|..|.|..:|.:.:..:....|.            |...||..:
Human   206 -------MKEQEKGEGSDSKESPKTKSDESGEEKNG------------DEDCQRGGQ-------- 243

  Fly   519 TTGTAAGPALTKKIPKHKWRPLPIDLAKSSRPKPIGGRPNRRFSDDIADQRRPPRVYHDRQPGAG 583
                      .||..||||.||.||:......:.:..||.           |||
Human   244 ----------KKKGNKHKWVPLQIDMKPEVPREKLASRPT-----------RPP----------- 276

  Fly   584 GAGVESRHPHAGRHPY-GSRPAT--ATSERVDSWRSSSSTTTAAFDEQRSGAAGGAGAAGTGVGS 645
                |.||..|.|... ||..||  ..:....:|:.......|..|:..:.:....||.|.
Human   277 ----EPRHIPANRGEIKGSESATYVPVAPPTPAWQPEIKPEPAWHDQDETSSVKSDGAGGA---- 333

  Fly   646 ATRGPRRYRTPYRGGRQGRGGFSRQGPGRPTYRIPRHLLASGEYA-NYLPADAAGADSQSSYVLM 709
                    |..:||..:|||    :|.||.......|.    :|. .|...|.........|:..
Human   334 --------RASFRGRGRGRG----RGRGRGRGGTRTHF----DYQFGYRKFDGVEGPRTPKYMNN 382

  Fly   710 GTHYFGNVPAAYI-ELDANSIKEAIKKQVEYYFSVDNLTGDFFLRRKMDPEGYIPVTLIASFHRV 773
            .|:||.||.:..: .:|...:|:.||:|:|||||||||..|||||||||.:|::|:|||||||||
Human   383 ITYYFDNVSSTELYSVDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRV 447

  Fly   774 LALTTDVAVIVNAIKESDKLELFEGYKVRTKTTPTTWPITEVPEVNEGEPKAIGTLEQEQLEQND 838
            .|||||:::|..|:|:|..:|:.: .|||.:..|..||:
Human   448 QALTTDISLIFAALKDSKVVEIVD-EKVRRREEPEKWPL-------------------------- 485

  Fly   839 GQEKLEEQTEADSPPPILTSAMA--TKPLNSIPPPPMPRNPQNLVPKMLQDKQQSRSSTIAALNS 901
                          |||:..:..  ::.||.  |..:||             |..:..|.:|..|
Human   486 --------------PPIVDYSQTDFSQLLNC--PEFVPR-------------QHYQKETESAPGS 521

  Fly   902 VNAISALTQQVEGGAAELAGHLSGLAESVKPKSTSTPDKRNAASAGNGAGSAAALVAEPEGIWKE 966
            ..|::.:..:.|        .:|.|....|..|.|.||                  .:.|. |.|
Human   522 PRAVTPVPTKTE--------EVSNLKTLPKGLSASLPD------------------LDSEN-WIE 559

  Fly   967 VKRRSKTNAIKENATTPPQQQQPPLSQTLNNNNDNVKTNNTSSKSKSSSNNAPSNASSSATVCVT 1031
            ||:|.:           |...:|..|:
Human   560 VKKRPR-----------PSPARPKKSE-------------------------------------- 575

  Fly  1032 TNNASSATKATTKTTTTSTATTTTNNNIKSGNAAYSKTHSKSSSKTAAP---PSAQCHA----EK 1089
                                                  .|:.|..|:.|   ||.|..:    |:
Human   576 --------------------------------------ESRFSHLTSLPQQLPSQQLMSKDQDEQ 602

  Fly  1090 EELDFQFDEEL--MDPLPPGTGRINNFTENFSDDDESDYEFADRDINKLLIVAQVGR-APKHEGY 1151
            |||||.||||:  ||      ||.|.||.  ..|:|||||..|||:||:|||.|... ..:|.|.
Human   603 EELDFLFDEEMEQMD------GRKNTFTA--WSDEESDYEIDDRDVNKILIVTQTPHYMRRHPGG 659

  Fly  1152 DRTADFTSRTKITQDLENIINDGLVNYEEDLWT---------TTNVVADYKTVNVISQADFEKLA 1207
            |||.:.|||.|::.:|..:|||||..||:|||.         ....|.::|.||:||:..|:.|.
Human   660 DRTGNHTSRAKMSAELAKVINDGLFYYEQDLWAEKFEPEYSQIKQEVENFKKVNMISREQFDTLT 724

  Fly  1208 GGRNKSVLPPQVVPP-PPPFEEDLDETLVG-------DTTLNSTLNNTL---------------- 1248
              ....|.|.|.||| ||.|::...:.|..       .:|:..:|..|:
Human   725 --PEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNTRTPRTPR 787

  Fly  1249 ------KSRRARFY-AAPNSHSIDPRTPRKRKLRHTANPPVEAHVGWLLDTVEHRPRTTSMGS-- 1304
                  .|:.:||| ......::|.:.|||||.||::|||:|:||||::|:.||||||.|:.|
Human   788 TPQLKDSSQTSRFYPVVKEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSREHRPRTASISSSP 852

  Fly  1305 SAGTSPTASSYGSFGSSVPQSLPVFQHPSHALLKENNFTQQAYHKYHSRCLKERRRLGYGQSQEM 1369
            |.|| ||..|||    ..|||||.||||||.|||||.|||..||||..|||.||:|||.||||||
Human   853 SEGT-PTVGSYG----CTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEM 912

  Fly  1370 NTLYRFWSFFLRENFNKSMYNEFRSLALEDAGNGFRYGLECLFRFFSYGLEKKFRPNIYQDFQDE 1434
            |||:||||||||::|||.||.||:.||||||..|:|||||||||::|||||||||.:|::|||:|
Human   913 NTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEE 977

  Fly  1435 TIADYETGQLYGLEKFWAFLKYYKNGEKLEVQPKLAEYLKSFKNIEDFRVVEPEINEMLQGVGSL 1499
            |:.|||.|||||||||||||||.| .:.|::.|||.|||..|:.:|||||..|
Human   978 TVKDYEAGQLYGLEKFWAFLKYSK-AKNLDIDPKLQEYLGKFRRLEDFRVDPP------------ 1029

  Fly  1500 NPGRQLNRHRSVSESDGTAVIAAGG 1524
             .|.:.|..|.       :|:|.||
Human  1030 -MGEEGNHKRH-------SVVAGGG 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
larp	NP_001247347.1	LARP_1_2	730..803	CDD:153403	46/73 (63%)
		DM15	1341..1382	CDD:128927	32/41 (78%)
		DM15	1383..1421	CDD:128927	28/38 (74%)
LARP1	NP_291029.2	Required for interaction with PABPC1. {ECO:0000269|PubMed:29244122}	77..573		182/779 (23%)
		LARP_1	404..476	CDD:153406	46/73 (63%)
		Required for interaction with RPTOR and for repression of mRNAs with a 5'TOP motif. {ECO:0000269|PubMed:29244122}	574..1096		244/586 (42%)
		Interaction with mRNA. {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:26206669}	873..1023		108/151 (72%)
		DM15	885..925	CDD:128927	32/40 (80%)
		DM15	926..964	CDD:128927	28/38 (74%)
		Interaction with 7-methylguanosine mRNA cap structure. {ECO:0000244|PDB:5V87, ECO:0000269|PubMed:28379136}	956..999		33/43 (77%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG5193
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1118
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D258488at2759
OrthoFinder	1	1.000				FOG0001428
OrthoInspector	1	1.000				T609611
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR22792
Phylome	1	0.910		0.800	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R1945
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	10	9.960