DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment larp and LARP1

DIOPT Version :9

Sequence 1:	NP_001247347.1	Gene:	larp / 53567	FlyBaseID:	FBgn0261618	Length:	1673	Species:	Drosophila melanogaster
Sequence 2:	NP_291029.2	Gene:	LARP1 / 23367	HGNCID:	29531	Length:	1096	Species:	Homo sapiens

Alignment Length:	1455	Identity:	446/1455 - (30%)
Similarity:	587/1455 - (40%)	Gaps:	506/1455 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 GGRGDGQKPQQAGGRRVPGSSDTERKSVRPRAPRGGSPRKSAAGAAGAAGSNAGAVSSAVPGGPK 210
            ||....:.|....|:..||.:|.          |||.|              .|:.....|...|
Human    22 GGLVRKKPPPAPEGKGEPGPNDV----------RGGEP--------------DGSARRPRPPCAK 62

  Fly   211 VHKDRKDTSPSASIEGAGSSGNEAKS------------ADGDQQAGEK----GAAGAAPPPKR-F 258
            .||           ||.|....|:..            :||::..||.    ||||||...:| |
Human    63 PHK-----------EGTGQQERESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGRRDF 116

  Fly   259 IAAPPPKVNAWKISAKQSGSPKAGTSPLDKRVLQPKAQQQQQQTKQTASQNNNAQNTASNKKTQQ 323
            :.|||||||.|                 .|..|.|..                        .|..
Human   117 VEAPPPKVNPW-----------------TKNALPPVL------------------------TTVN 140

  Fly   324 QQQPQQGATTTTQTTTAAAAAATAAAAATAATTSAAAATSSAAAVPAATTETATTTTVDASQADA 388
            .|.|.:                           .:|.|....||||
Human   141 GQSPPE---------------------------HSAPAKVVRAAVP------------------- 159

  Fly   389 LAKVVVKDKKKVNQKASDFSNVGDWPTLIGGTSGSGKATSNEPKRNPTKKQQSAKTAAAVAASSN 453
                    |::...|..||.:..:|||.......|.:..|::|:  ||:|....|.
Human   160 --------KQRKGSKVGDFGDAINWPTPGEIAHKSVQPQSHKPQ--PTRKLPPKKD--------- 205

  Fly   454 TTSSEVATESNVAGTTSSSNSNPSSSTTTTNTTTNSQATTAPVASTSHDAKAQRDAEPAANSAAG 518
                   .:....|..|.|..:|.:.:..:....|.            |...||..:
Human   206 -------MKEQEKGEGSDSKESPKTKSDESGEEKNG------------DEDCQRGGQ-------- 243

  Fly   519 TTGTAAGPALTKKIPKHKWRPLPIDLAKSSRPKPIGGRPNRRFSDDIADQRRPPRVYHDRQPGAG 583
                      .||..||||.||.||:......:.:..||.           |||
Human   244 ----------KKKGNKHKWVPLQIDMKPEVPREKLASRPT-----------RPP----------- 276

  Fly   584 GAGVESRHPHAGRHPY-GSRPAT--ATSERVDSWRSSSSTTTAAFDEQRSGAAGGAGAAGTGVGS 645
                |.||..|.|... ||..||  ..:....:|:.......|..|:..:.:....||.|.
Human   277 ----EPRHIPANRGEIKGSESATYVPVAPPTPAWQPEIKPEPAWHDQDETSSVKSDGAGGA---- 333

  Fly   646 ATRGPRRYRTPYRGGRQGRGGFSRQGPGRPTYRIPRHLLASGEYA-NYLPADAAGADSQSSYVLM 709
                    |..:||..:|||    :|.||.......|.    :|. .|...|.........|:..
Human   334 --------RASFRGRGRGRG----RGRGRGRGGTRTHF----DYQFGYRKFDGVEGPRTPKYMNN 382

  Fly   710 GTHYFGNVPAAYI-ELDANSIKEAIKKQVEYYFSVDNLTGDFFLRRKMDPEGYIPVTLIASFHRV 773
            .|:||.||.:..: .:|...:|:.||:|:|||||||||..|||||||||.:|::|:|||||||||
Human   383 ITYYFDNVSSTELYSVDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRV 447

  Fly   774 LALTTDVAVIVNAIKESDKLELFEGYKVRTKTTPTTWPITEVPEVNEGEPKAIGTLEQEQLEQND 838
            .|||||:::|..|:|:|..:|:.: .|||.:..|..||:
Human   448 QALTTDISLIFAALKDSKVVEIVD-EKVRRREEPEKWPL-------------------------- 485

  Fly   839 GQEKLEEQTEADSPPPILTSAMA--TKPLNSIPPPPMPRNPQNLVPKMLQDKQQSRSSTIAALNS 901
                          |||:..:..  ::.||.  |..:||             |..:..|.:|..|
Human   486 --------------PPIVDYSQTDFSQLLNC--PEFVPR-------------QHYQKETESAPGS 521

  Fly   902 VNAISALTQQVEGGAAELAGHLSGLAESVKPKSTSTPDKRNAASAGNGAGSAAALVAEPEGIWKE 966
            ..|::.:..:.|        .:|.|....|..|.|.||                  .:.|. |.|
Human   522 PRAVTPVPTKTE--------EVSNLKTLPKGLSASLPD------------------LDSEN-WIE 559

  Fly   967 VKRRSKTNAIKENATTPPQQQQPPLSQTLNNNNDNVKTNNTSSKSKSSSNNAPSNASSSATVCVT 1031
            ||:|.:           |...:|..|:
Human   560 VKKRPR-----------PSPARPKKSE-------------------------------------- 575

  Fly  1032 TNNASSATKATTKTTTTSTATTTTNNNIKSGNAAYSKTHSKSSSKTAAP---PSAQCHA----EK 1089
                                                  .|:.|..|:.|   ||.|..:    |:
Human   576 --------------------------------------ESRFSHLTSLPQQLPSQQLMSKDQDEQ 602

  Fly  1090 EELDFQFDEEL--MDPLPPGTGRINNFTENFSDDDESDYEFADRDINKLLIVAQVGR-APKHEGY 1151
            |||||.||||:  ||      ||.|.||.  ..|:|||||..|||:||:|||.|... ..:|.|.
Human   603 EELDFLFDEEMEQMD------GRKNTFTA--WSDEESDYEIDDRDVNKILIVTQTPHYMRRHPGG 659

  Fly  1152 DRTADFTSRTKITQDLENIINDGLVNYEEDLWT---------TTNVVADYKTVNVISQADFEKLA 1207
            |||.:.|||.|::.:|..:|||||..||:|||.         ....|.::|.||:||:..|:.|.
Human   660 DRTGNHTSRAKMSAELAKVINDGLFYYEQDLWAEKFEPEYSQIKQEVENFKKVNMISREQFDTLT 724

  Fly  1208 GGRNKSVLPPQVVPP-PPPFEEDLDETLVG-------DTTLNSTLNNTL---------------- 1248
              ....|.|.|.||| ||.|::...:.|..       .:|:..:|..|:
Human   725 --PEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNTRTPRTPR 787

  Fly  1249 ------KSRRARFY-AAPNSHSIDPRTPRKRKLRHTANPPVEAHVGWLLDTVEHRPRTTSMGS-- 1304
                  .|:.:||| ......::|.:.|||||.||::|||:|:||||::|:.||||||.|:.|
Human   788 TPQLKDSSQTSRFYPVVKEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSREHRPRTASISSSP 852

  Fly  1305 SAGTSPTASSYGSFGSSVPQSLPVFQHPSHALLKENNFTQQAYHKYHSRCLKERRRLGYGQSQEM 1369
            |.|| ||..|||    ..|||||.||||||.|||||.|||..||||..|||.||:|||.||||||
Human   853 SEGT-PTVGSYG----CTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEM 912

  Fly  1370 NTLYRFWSFFLRENFNKSMYNEFRSLALEDAGNGFRYGLECLFRFFSYGLEKKFRPNIYQDFQDE 1434
            |||:||||||||::|||.||.||:.||||||..|:|||||||||::|||||||||.:|::|||:|
Human   913 NTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEE 977

  Fly  1435 TIADYETGQLYGLEKFWAFLKYYKNGEKLEVQPKLAEYLKSFKNIEDFRVVEPEINEMLQGVGSL 1499
            |:.|||.|||||||||||||||.| .:.|::.|||.|||..|:.:|||||..|
Human   978 TVKDYEAGQLYGLEKFWAFLKYSK-AKNLDIDPKLQEYLGKFRRLEDFRVDPP------------ 1029

  Fly  1500 NPGRQLNRHRSVSESDGTAVIAAGG 1524
             .|.:.|..|.       :|:|.||
Human  1030 -MGEEGNHKRH-------SVVAGGG 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
larp	NP_001247347.1	LARP_1_2	730..803	CDD:153403	45/72 (63%)
		DM15	1341..1382	CDD:128927	31/40 (78%)
		DM15	1383..1421	CDD:128927	27/37 (73%)
LARP1	NP_291029.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..356		113/553 (20%)
		Required for interaction with PABPC1. /evidence=ECO:0000269\|PubMed:29244122	77..573		182/778 (23%)
		LARP_1	404..476	CDD:153406	45/72 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..598		28/200 (14%)
		Required for interaction with RPTOR and for repression of mRNAs with a 5'TOP motif. /evidence=ECO:0000269\|PubMed:29244122	574..1096		244/585 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	759..861		37/102 (36%)
		Interaction with mRNA. /evidence=ECO:0000269\|PubMed:20430826, ECO:0000269\|PubMed:26206669	873..1023		107/150 (71%)
		DM15	885..925	CDD:128927	31/39 (79%)
		DM15	926..964	CDD:128927	27/37 (73%)
		Interaction with 7-methylguanosine mRNA cap structure. /evidence=ECO:0000269\|PubMed:28379136, ECO:0007744\|PDB:5V87	956..999		32/42 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1026..1096		9/41 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	383	1.000	Domainoid score	I827
eggNOG	1	0.900	-	-		E1_COG5193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1136
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258488at2759
OrthoFinder	1	1.000	-	-		FOG0001290
OrthoInspector	1	1.000	-	-		otm40535
orthoMCL	1	0.900	-	-		OOG6_103868
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1945
SonicParanoid	1	1.000	-	-		X2271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860