DRSC/TRiP Functional Genomics Resources

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Protein Alignment larp and LARP1

DIOPT Version :10

Sequence 1:NP_733244.5 Gene:larp / 53567 FlyBaseID:FBgn0261618 Length:1673 Species:Drosophila melanogaster
Sequence 2:NP_291029.2 Gene:LARP1 / 23367 HGNCID:29531 Length:1096 Species:Homo sapiens


Alignment Length:1455 Identity:446/1455 - (30%)
Similarity:587/1455 - (40%) Gaps:506/1455 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   146 GGRGDGQKPQQAGGRRVPGSSDTERKSVRPRAPRGGSPRKSAAGAAGAAGSNAGAVSSAVPGGPK 210
            ||....:.|....|:..||.:|.          |||.|              .|:.....|...|
Human    22 GGLVRKKPPPAPEGKGEPGPNDV----------RGGEP--------------DGSARRPRPPCAK 62

  Fly   211 VHKDRKDTSPSASIEGAGSSGNEAKS------------ADGDQQAGEK----GAAGAAPPPKR-F 258
            .||           ||.|....|:..            :||::..||.    ||||||...:| |
Human    63 PHK-----------EGTGQQERESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGRRDF 116

  Fly   259 IAAPPPKVNAWKISAKQSGSPKAGTSPLDKRVLQPKAQQQQQQTKQTASQNNNAQNTASNKKTQQ 323
            :.|||||||.|                 .|..|.|..                        .|..
Human   117 VEAPPPKVNPW-----------------TKNALPPVL------------------------TTVN 140

  Fly   324 QQQPQQGATTTTQTTTAAAAAATAAAAATAATTSAAAATSSAAAVPAATTETATTTTVDASQADA 388
            .|.|.:                           .:|.|....||||                   
Human   141 GQSPPE---------------------------HSAPAKVVRAAVP------------------- 159

  Fly   389 LAKVVVKDKKKVNQKASDFSNVGDWPTLIGGTSGSGKATSNEPKRNPTKKQQSAKTAAAVAASSN 453
                    |::...|..||.:..:|||.......|.:..|::|:  ||:|....|.         
Human   160 --------KQRKGSKVGDFGDAINWPTPGEIAHKSVQPQSHKPQ--PTRKLPPKKD--------- 205

  Fly   454 TTSSEVATESNVAGTTSSSNSNPSSSTTTTNTTTNSQATTAPVASTSHDAKAQRDAEPAANSAAG 518
                   .:....|..|.|..:|.:.:..:....|.            |...||..:        
Human   206 -------MKEQEKGEGSDSKESPKTKSDESGEEKNG------------DEDCQRGGQ-------- 243

  Fly   519 TTGTAAGPALTKKIPKHKWRPLPIDLAKSSRPKPIGGRPNRRFSDDIADQRRPPRVYHDRQPGAG 583
                      .||..||||.||.||:......:.:..||.           |||           
Human   244 ----------KKKGNKHKWVPLQIDMKPEVPREKLASRPT-----------RPP----------- 276

  Fly   584 GAGVESRHPHAGRHPY-GSRPAT--ATSERVDSWRSSSSTTTAAFDEQRSGAAGGAGAAGTGVGS 645
                |.||..|.|... ||..||  ..:....:|:.......|..|:..:.:....||.|.    
Human   277 ----EPRHIPANRGEIKGSESATYVPVAPPTPAWQPEIKPEPAWHDQDETSSVKSDGAGGA---- 333

  Fly   646 ATRGPRRYRTPYRGGRQGRGGFSRQGPGRPTYRIPRHLLASGEYA-NYLPADAAGADSQSSYVLM 709
                    |..:||..:|||    :|.||.......|.    :|. .|...|.........|:..
Human   334 --------RASFRGRGRGRG----RGRGRGRGGTRTHF----DYQFGYRKFDGVEGPRTPKYMNN 382

  Fly   710 GTHYFGNVPAAYI-ELDANSIKEAIKKQVEYYFSVDNLTGDFFLRRKMDPEGYIPVTLIASFHRV 773
            .|:||.||.:..: .:|...:|:.||:|:|||||||||..|||||||||.:|::|:|||||||||
Human   383 ITYYFDNVSSTELYSVDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRV 447

  Fly   774 LALTTDVAVIVNAIKESDKLELFEGYKVRTKTTPTTWPITEVPEVNEGEPKAIGTLEQEQLEQND 838
            .|||||:::|..|:|:|..:|:.: .|||.:..|..||:                          
Human   448 QALTTDISLIFAALKDSKVVEIVD-EKVRRREEPEKWPL-------------------------- 485

  Fly   839 GQEKLEEQTEADSPPPILTSAMA--TKPLNSIPPPPMPRNPQNLVPKMLQDKQQSRSSTIAALNS 901
                          |||:..:..  ::.||.  |..:||             |..:..|.:|..|
Human   486 --------------PPIVDYSQTDFSQLLNC--PEFVPR-------------QHYQKETESAPGS 521

  Fly   902 VNAISALTQQVEGGAAELAGHLSGLAESVKPKSTSTPDKRNAASAGNGAGSAAALVAEPEGIWKE 966
            ..|::.:..:.|        .:|.|....|..|.|.||                  .:.|. |.|
Human   522 PRAVTPVPTKTE--------EVSNLKTLPKGLSASLPD------------------LDSEN-WIE 559

  Fly   967 VKRRSKTNAIKENATTPPQQQQPPLSQTLNNNNDNVKTNNTSSKSKSSSNNAPSNASSSATVCVT 1031
            ||:|.:           |...:|..|:                                      
Human   560 VKKRPR-----------PSPARPKKSE-------------------------------------- 575

  Fly  1032 TNNASSATKATTKTTTTSTATTTTNNNIKSGNAAYSKTHSKSSSKTAAP---PSAQCHA----EK 1089
                                                  .|:.|..|:.|   ||.|..:    |:
Human   576 --------------------------------------ESRFSHLTSLPQQLPSQQLMSKDQDEQ 602

  Fly  1090 EELDFQFDEEL--MDPLPPGTGRINNFTENFSDDDESDYEFADRDINKLLIVAQVGR-APKHEGY 1151
            |||||.||||:  ||      ||.|.||.  ..|:|||||..|||:||:|||.|... ..:|.|.
Human   603 EELDFLFDEEMEQMD------GRKNTFTA--WSDEESDYEIDDRDVNKILIVTQTPHYMRRHPGG 659

  Fly  1152 DRTADFTSRTKITQDLENIINDGLVNYEEDLWT---------TTNVVADYKTVNVISQADFEKLA 1207
            |||.:.|||.|::.:|..:|||||..||:|||.         ....|.::|.||:||:..|:.|.
Human   660 DRTGNHTSRAKMSAELAKVINDGLFYYEQDLWAEKFEPEYSQIKQEVENFKKVNMISREQFDTLT 724

  Fly  1208 GGRNKSVLPPQVVPP-PPPFEEDLDETLVG-------DTTLNSTLNNTL---------------- 1248
              ....|.|.|.||| ||.|::...:.|..       .:|:..:|..|:                
Human   725 --PEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNTRTPRTPR 787

  Fly  1249 ------KSRRARFY-AAPNSHSIDPRTPRKRKLRHTANPPVEAHVGWLLDTVEHRPRTTSMGS-- 1304
                  .|:.:||| ......::|.:.|||||.||::|||:|:||||::|:.||||||.|:.|  
Human   788 TPQLKDSSQTSRFYPVVKEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSREHRPRTASISSSP 852

  Fly  1305 SAGTSPTASSYGSFGSSVPQSLPVFQHPSHALLKENNFTQQAYHKYHSRCLKERRRLGYGQSQEM 1369
            |.|| ||..|||    ..|||||.||||||.|||||.|||..||||..|||.||:|||.||||||
Human   853 SEGT-PTVGSYG----CTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEM 912

  Fly  1370 NTLYRFWSFFLRENFNKSMYNEFRSLALEDAGNGFRYGLECLFRFFSYGLEKKFRPNIYQDFQDE 1434
            |||:||||||||::|||.||.||:.||||||..|:|||||||||::|||||||||.:|::|||:|
Human   913 NTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEE 977

  Fly  1435 TIADYETGQLYGLEKFWAFLKYYKNGEKLEVQPKLAEYLKSFKNIEDFRVVEPEINEMLQGVGSL 1499
            |:.|||.|||||||||||||||.| .:.|::.|||.|||..|:.:|||||..|            
Human   978 TVKDYEAGQLYGLEKFWAFLKYSK-AKNLDIDPKLQEYLGKFRRLEDFRVDPP------------ 1029

  Fly  1500 NPGRQLNRHRSVSESDGTAVIAAGG 1524
             .|.:.|..|.       :|:|.||
Human  1030 -MGEEGNHKRH-------SVVAGGG 1046

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
larpNP_733244.5 LARP_1_2 730..803 CDD:153403 45/72 (63%)
DM15 1341..1382 CDD:128927 31/40 (78%)
DM15 1383..1421 CDD:128927 27/37 (73%)
LARP1NP_291029.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..356 113/553 (20%)
PHA03247 <2..328 CDD:223021 101/509 (20%)
Required for interaction with PABPC1. /evidence=ECO:0000269|PubMed:29244122 77..573 182/778 (23%)
LARP_1 404..476 CDD:153406 45/72 (63%)
LHP1 <407..576 CDD:227520 78/338 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 511..598 28/200 (14%)
Required for interaction with RPTOR and for repression of mRNAs with a 5'TOP motif. /evidence=ECO:0000269|PubMed:29244122 574..1096 244/585 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 759..861 37/102 (36%)
Interaction with mRNA. /evidence=ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:26206669 873..1023 107/150 (71%)
DM15 885..925 CDD:128927 31/39 (79%)
DM15 926..964 CDD:128927 27/37 (73%)
Interaction with 7-methylguanosine mRNA cap structure. /evidence=ECO:0000269|PubMed:28379136, ECO:0007744|PDB:5V87 956..999 32/42 (76%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1026..1096 9/41 (22%)

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