Protein Alignment cic and Bbx

DIOPT Version :10

• Sequence 1: NP_001262755.1
• Gene: cic / 53560
• FlyBaseID: FBgn0262582
• Length: 2150
• Species: Drosophila melanogaster
• Sequence 2: XP_006522606.1
• Gene: Bbx / 70508
• MGIID: 1917758
• Length: 937
• Species: Mus musculus
• Alignment Length: 1052
• Identity: 207/1052 - (19%)
• Similarity: 326/1052 - (30%)
• Gaps: 380/1052 - (36%)

  Fly  1202 QSLSALQQQQQQQQQAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKIL 1266
            :.:..:|..:....:...|.|...:...::.|||||||::|.|:||.:|.::||..|||..:|||
Mouse    50 EDIDKVQLLEADGLEQDVAETEDDESPEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKIL 114

  Fly  1267 GEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRR--KSSTSTATPGGKASGAAGTGDA 1329
            .:||..|.|::|.:|.::|...|||..|.:|.::||....:  ||.|.|..|
Mouse   115 ADWWAVLDPKEKQKYTDMAKEYKDAFMKANPGYRWCPTTNKPVKSPTPTVNP------------- 166

  Fly  1330 KQRLVSVDGSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAPTTISMKGN 1394
            :::|.:.              |..|        |.||                   ||.
Mouse   167 RKKLWAF--------------PPDS--------SRDL-------------------PTP------ 184

  Fly  1395 GNGKLMKNELP------SDEDE----QMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRK 1449
               |..|.|:|      :|..:    .||::..|....|.:.....||..:::|
Mouse   185 ---KKAKTEVPQLNFGMADPTQMGGLSMLLLAGEHALGTPEASSGTCRPDISES----------- 235

  Fly  1450 QQPEANQRS-----AEEHSTSGANGQAINAPPLSGGEREITLKPKAIKAHPVLESNMLPYTQMSI 1509
              ||..|:|     ||..|.:                           :||...|.....:.:..
Mouse   236 --PELRQKSPLFQFAEISSRT---------------------------SHPDAPSKQCQASALFQ 271

  Fly  1510 YTQYTSPKNPIGVT-PFQPTGGA--FKSMPISPKGSGGKPEDAGSLQAHIKQED----------- 1560
            :.:.:|..:.:|.| |.:..|.:  |:...:.....|.|.||...:::  |:.|
Mouse   272 FAEISSSTSQLGGTEPVKRCGNSALFQLAEMCLASEGVKMEDTKLIKS--KESDGGRIEEIEKGK 334

  Fly  1561 ------IKQEPPSPYKLNNGSGSASGGGVVSAPPPNSGSVGAIFNFNVPTATAL----------- 1608
                  :::...:.::.....|.::.|.|     ..|..:..|....:....|:
Mouse   335 EERGTEVEKTTETSFQKEAEFGKSAKGNV-----RESKDLRDIEQLQMDNVMAIKVEDPKEIRKE 394

  Fly  1609 ---SQKQFHYP---------------------MHHPH-----RSPTDLRAAHQACVPSSPAGMGL 1644
               .||..|:|                     |.|||     ..||.|....:.........:.
Mouse   395 PEDDQKYSHFPDFSYSASSKIIISGVPSRKDHMCHPHGIMIIEDPTTLNKPEKIKKKKKKNKLD- 458

  Fly  1645 GHAANIATPPASAPAQIMGGGPASQKMFFAMTHPYTLLQRSHQPGTPSLEHLQ--LDAFAPGGYT 1707
            .|..:.:||..:.                          :..|.....:|.:.  ::|.|.|.:
Mouse   459 RHGNDKSTPKKTC--------------------------KKRQSSESDIESVMYTIEAVAKGDW- 496

  Fly  1708 LRNHNGLSSL--PPPVSAQPTM-----LLHGYPPSHGVEPPARSPSYKSMPSTPKSATYLMSAPP 1765
                 |:..|  .|....:|:.     :|...||...|:...:..|.:......|.     |.||
Mouse   497 -----GVDKLGETPRKKVRPSSSGKGGILDAKPPKKKVKSKEKKVSKEKCSDITKE-----SRPP 551

  Fly  1766 ERGMDGGMSGCASAAASGGDESDIDADGQQFILAPT-----PAQLGRAPLQ------RRKNLSQS 1819
            :     .:|..||.:..|.....|.|:.    |.||     |:..|:|..:      :.:.....
Mouse   552 D-----FLSISASKSVPGEVPEGIKAEP----LTPTEDALPPSLPGQAKPEDSDCHRKTETCGSR 607

  Fly  1820 KSESNVSFGANLGASNGQHISRKLHSPTMMESSSPIIGHVNSSNLSSALPTPTSSTTTPNSDEQL 1884
            |||.:..     ||     :.:.|.|..|:.|   :..:|:....||....        :||.:
Mouse   608 KSERSCK-----GA-----LYKTLVSEGMLTS---LRANVDRGKRSSGKGN--------SSDHE- 650

  Fly  1885 PLTPTTSSSNSNLNQQQPKSPMKGAPGSTAAALKKKNDEMNNSVLKQVDFEKKYKALPQFQP--- 1946
               ...|..:...||       .|..||.....|.:.|....|.....:||||:.:|||:.|
Mouse   651 ---GCWSEESWTFNQ-------SGTSGSKKFKKKLREDSFLGSAKLDEEFEKKFNSLPQYSPITF 705

  Fly  1947 -EDCQSPSAIAVPSSPRVYG--------------------------TNYRKKNTAP--------- 1975
             ..|     ::.|...:..|                          :.|:.|...|
Mouse   706 DRKC-----VSTPRKKKKTGNMSSESTKTSKGPFQSQKKNLFHKIVSKYKHKKEKPNVPEKGSGD 765

  Fly  1976 ------------PPVQKLMCEDDSIDEPA-------SAP----PTTTQR-FFGPDFNNELKDE-- 2014
                        .|.:.:..||.|..|||       |.|    |||.|. ..|.......|.:
Mouse   766 KWSHKQFFLDAIHPTEAIFSEDKSTTEPAFKVKNALSIPNTPEPTTMQEPLVGSQKRKARKTKIT 830

  Fly  2015 ---RLAELESSDQTGRSPRTPKTPLQSARSDASEKG--------HRKVLETRRSLVLQLFAEHGN 2068
               |.|:...|...|.....||..||  ||.....|        |..|.|.|.|.
Mouse   831 HLVRTADGRVSPAGGTLDDKPKEQLQ--RSLPKVPGTYCGDNCSHSTVEEPRSST---------- 883

  Fly  2069 FPTAQATMAFQS 2080
             |...|..||.|
Mouse   884 -PDMPAVSAFFS 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..432	CDD:465014
		HMG-box_CIC-like	1231..1308	CDD:438806	34/78 (44%)
Bbx	XP_006522606.1	HMG-box_HBP2	81..149	CDD:438805	32/67 (48%)
		DUF2028	190..321	CDD:430742	30/172 (17%)