DRSC/TRiP Functional Genomics Resources

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Protein Alignment cic and SOX12

DIOPT Version :10

Sequence 1:NP_001262755.1 Gene:cic / 53560 FlyBaseID:FBgn0262582 Length:2150 Species:Drosophila melanogaster
Sequence 2:NP_008874.2 Gene:SOX12 / 6666 HGNCID:11198 Length:315 Species:Homo sapiens


Alignment Length:353 Identity:70/353 - (19%)
Similarity:119/353 - (33%) Gaps:124/353 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1186 DGAAGAPATSAAKRRSQSLSALQQQQQQQQQAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKMV 1250
            ||....|....|             ::..::.|...|.:|.     |:|||||||::|:..|:.:
Human    12 DGGPPPPGPGPA-------------EEGAREPGWCKTPSGH-----IKRPMNAFMVWSQHERRKI 58

  Fly  1251 HKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTSTAT 1315
            ..:.|:..|..:||.||..|..|:..:|..:...|..::..|...:|::|:             .
Human    59 MDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKY-------------R 110

  Fly  1316 PGGKASGAAGTGDAKQRLVSVDGSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNS 1380
            |..|:.||    .||.|               |..|||||  ||..:....|             
Human   111 PRKKSKGA----PAKAR---------------PRPPGGSG--GGSRLKPGPQ------------- 141

  Fly  1381 TCDEAPTTISMKGNGNGKLMKNEL------PSDEDEQMLVVEEEQQQQTVKKIDLHCRE------ 1433
                      :.|.|..:.....|      |.|:||     :::::...|:.::...||      
Human   142 ----------LPGRGGRRAAGGPLGGGAAAPEDDDE-----DDDEELLEVRLVETPGRELWRMVP 191

  Fly  1434 ------------------------RVNDSDMDDTPFDYRKQQPEANQRSAEEHSTSGAN--GQAI 1472
                                    ..:.:..:|...:..:::..|.:...||...||..  |...
Human   192 AGRAARGQAERAQGPSGEGAAAAAAASPTPSEDEEPEEEEEEAAAAEEGEEETVASGEESLGFLS 256

  Fly  1473 NAPPLSGG------EREITLKPKAIKAH 1494
            ..||...|      :|:..|:|.:..:|
Human   257 RLPPGPAGLDCSALDRDPDLQPPSGTSH 284

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cicNP_001262755.1 DUF4819 349..432 CDD:465014
HMG-box_CIC-like 1231..1308 CDD:438806 23/76 (30%)
SOX12NP_008874.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 7/45 (16%)
HMG-box_SF 29..116 CDD:469606 28/104 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 100..288 43/247 (17%)
Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000250|UniProtKB:Q04890 283..315 1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

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