DRSC/TRiP Functional Genomics Resources

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Protein Alignment cic and SOX11

DIOPT Version :10

Sequence 1:NP_001262755.1 Gene:cic / 53560 FlyBaseID:FBgn0262582 Length:2150 Species:Drosophila melanogaster
Sequence 2:NP_003099.1 Gene:SOX11 / 6664 HGNCID:11191 Length:441 Species:Homo sapiens


Alignment Length:415 Identity:97/415 - (23%)
Similarity:159/415 - (38%) Gaps:81/415 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly  1222 TAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELAS 1286
            ||:|.     |:|||||||::||..|:.:.::.|:..|..:||.||:.|..||..:|..:...|.
Human    44 TASGH-----IKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAE 103

  Fly  1287 SVKDAHFKLHPEWKWCSKDRRK-----------SSTSTATPGGKASGAAGTGDAKQRLVSVDGSD 1340
            .::..|...:|::|:..:.:.|           |...:|..||..|...|.|.||....|.....
Human   104 RLRLKHMADYPDYKYRPRKKPKMDPSAKPSASQSPEKSAAGGGGGSAGGGAGGAKTSKGSSKKCG 168

  Fly  1341 SLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDE---APTTISMKGNGN-GKLMK 1401
            .|:      .|..:|:..|.|.::. .||        |....|:   ....:|..|.|. ||.:|
Human   169 KLK------APAAAGAKAGAGKAAQ-SGD--------YGGAGDDYVLGSLRVSGSGGGGAGKTVK 218

  Fly  1402 -------NELPSDEDEQMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQPEANQRSA 1459
                   ::...|:||..|.:::|..::                  |:.|...:..||...|.|.
Human   219 CVFLDEDDDDDDDDDELQLQIKQEPDEE------------------DEEPPHQQLLQPPGQQPSQ 265

  Fly  1460 EEHSTSGANGQAINAPPLSGGEREITLKPKAIKAHPVLES---------NMLPYTQMSIYTQYTS 1515
            .....:.|...|  :|.||....    .|:....:..:.:         :.|.|:..:|..|:..
Human   266 LLRRYNVAKVPA--SPTLSSSAE----SPEGASLYDEVRAGATSGAGGGSRLYYSFKNITKQHPP 324

  Fly  1516 PKNPIGVTPFQPTGGAFKSMPISPKGSGGKPEDAGSLQAHIKQEDIKQEPPSPYKLNNGSGSASG 1580
            |.....::|......:..|...|...||...|||..|...:.. :..|...|..:...|.|:|:|
Human   325 PLAQPALSPASSRSVSTSSSSSSGSSSGSSGEDADDLMFDLSL-NFSQSAHSASEQQLGGGAAAG 388

  Fly  1581 GGVVSAPPP-----NSGSVGAIFNF 1600
            ...:|....     :.||:|:.|.|
Human   389 NLSLSLVDKDLDSFSEGSLGSHFEF 413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cicNP_001262755.1 DUF4819 349..432 CDD:465014
HMG-box_CIC-like 1231..1308 CDD:438806 25/76 (33%)
SOX11NP_003099.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
HMG-box_SoxC_SOX11 38..129 CDD:438846 29/89 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..216 25/114 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..292 13/75 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 319..359 9/39 (23%)
Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000250|UniProtKB:Q7M6Y2 409..441 2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

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