DRSC/TRiP Functional Genomics Resources

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Protein Alignment cic and SOX10

DIOPT Version :10

Sequence 1:NP_001262755.1 Gene:cic / 53560 FlyBaseID:FBgn0262582 Length:2150 Species:Drosophila melanogaster
Sequence 2:NP_008872.1 Gene:SOX10 / 6663 HGNCID:11190 Length:466 Species:Homo sapiens


Alignment Length:580 Identity:121/580 - (20%)
Similarity:190/580 - (32%) Gaps:238/580 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly  1186 DGAAGAPATSAAKRRSQSLSALQQQQQ-----------------QQQQAGAAGTAAGQP-----A 1228
            ||..|.....|:....: |..::::||                 .|..:|...|....|     |
Human    34 DGGGGGSGLRASPGPGE-LGKVKKEQQDGEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGA 97

  Fly  1229 NKK---IRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKD 1290
            :|.   ::|||||||::::..|:.:..::|:..|..:||.||:.|..|....|..:.|.|..::.
Human    98 SKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRM 162

  Fly  1291 AHFKLHPEWKWCSKDRRKSSTSTATPGGKASGAAGTGDAKQRLVSVDGSDSLEHDMCPSTPGGSG 1355
            .|.|.||::|:..: |||            :|.|..|:|:                |   |||..
Human   163 QHKKDHPDYKYQPR-RRK------------NGKAAQGEAE----------------C---PGGEA 195

  Fly  1356 SCGGQGISSDLQGDIIPLTIDNYNSTCDEAPTTISMKGNGNGKLMKNELPSDEDEQMLVVEEEQQ 1420
            ..||   ::.:|.        :|.|.                                       
Human   196 EQGG---TAAIQA--------HYKSA--------------------------------------- 210

  Fly  1421 QQTVKKIDLHCRERVNDSDMDDTPFDYRKQQPEANQRSAEEHSTSGANGQAINAPPLSGGEREIT 1485
                     |              .|:|             |...|:        |:|.|..|  
Human   211 ---------H--------------LDHR-------------HPGEGS--------PMSDGNPE-- 229

  Fly  1486 LKPKAIKAHPVLESNMLPYTQMSIYTQYTSPKNPIGVTPFQPTGGAFKSMPISPK------GSGG 1544
                    ||..:|:..|       |..|:||..:            :|....||      |.||
Human   230 --------HPSGQSHGPP-------TPPTTPKTEL------------QSGKADPKRDGRSMGEGG 267

  Fly  1545 KPE------DAGSL----QAHIKQEDIKQ----EPPSPYKLNNGSGSASGGGV------------ 1583
            ||.      |.|.:    .::::..|:.:    .||:.:..:..|.||:|.|:            
Human   268 KPHIDFGNVDIGEISHEVMSNMETFDVAELDQYLPPNGHPGHVSSYSAAGYGLGSALAVASGHSA 332

  Fly  1584 -VSAPP----PNSGSVGAIFNFNVPTATALSQKQFHYPMHHPHRSP---TDLRAAHQ-ACVPS-- 1637
             :|.||    |.....|......|.|.||..|...|| ...|..|.   |.|...|. :..||  
Human   333 WISKPPGVALPTVSPPGVDAKAQVKTETAGPQGPPHY-TDQPSTSQIAYTSLSLPHYGSAFPSIS 396

  Fly  1638 ---------SPAGMGLGHAANIATPPASAPAQIMGGGPASQKMFFAMTHPYTLLQRSHQP 1688
                     .|:|...||:.. |:...||.:.:   ||:.:.::.|::.|.....:||.|
Human   397 RPQFDYSDHQPSGPYYGHSGQ-ASGLYSAFSYM---GPSQRPLYTAISDPSPSGPQSHSP 452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cicNP_001262755.1 DUF4819 349..432 CDD:465014
HMG-box_CIC-like 1231..1308 CDD:438806 25/79 (32%)
SOX10NP_008872.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..67 7/33 (21%)
Sox_N 12..93 CDD:463586 11/59 (19%)
Dimerization (DIM). /evidence=ECO:0000303|PubMed:31194875 62..102 6/39 (15%)
HMG-box_SoxE 103..177 CDD:438840 24/74 (32%)
Nuclear export signal 134..145 5/10 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 160..199 16/70 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..274 24/111 (22%)
Transactivation domain (TAM). /evidence=ECO:0000303|PubMed:31194875 228..310 22/110 (20%)
Transactivation domain (TAC). /evidence=ECO:0000303|PubMed:31194875 353..466 28/105 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..375 8/21 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 433..466 5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

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