DRSC/TRiP Functional Genomics Resources

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Protein Alignment cic and SOX9

DIOPT Version :10

Sequence 1:NP_001262755.1 Gene:cic / 53560 FlyBaseID:FBgn0262582 Length:2150 Species:Drosophila melanogaster
Sequence 2:NP_000337.1 Gene:SOX9 / 6662 HGNCID:11204 Length:509 Species:Homo sapiens


Alignment Length:488 Identity:117/488 - (23%)
Similarity:174/488 - (35%) Gaps:109/488 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1225 GQPANK-KIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSV 1288
            |...|| .::|||||||::::..|:.:..::|:..|..:||.||:.|..|...:|..:.|.|..:
Human    97 GSSKNKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERL 161

  Fly  1289 KDAHFKLHPEWKWCSKDRRKSSTSTATPGGKASGAAGTGDAKQRLVSVDG-SDSLEHDMCPSTPG 1352
            :..|.|.||::|:..: ||||     ...|:|.....|   :|..:|.:. ..:|:.|...|:.|
Human   162 RVQHKKDHPDYKYQPR-RRKS-----VKNGQAEAEEAT---EQTHISPNAIFKALQADSPHSSSG 217

  Fly  1353 GS-----GSCGGQGISSDLQGDIIPLTIDNYNSTCDEAPTTISMKGNGNGKLMKNELPSDEDEQM 1412
            .|     |...||.     ||...|.|          .|.|....|..:.|.....||       
Human   218 MSEVHSPGEHSGQS-----QGPPTPPT----------TPKTDVQPGKADLKREGRPLP------- 260

  Fly  1413 LVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRK----QQPEANQRSAEEH---STSGANG- 1469
                |..:|..:...|:...|..:|...:...||..:    ..|..:......|   :.:|:.| 
Human   261 ----EGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLPPNGHPGVPATHGQVTYTGSYGI 321

  Fly  1470 QAINAPPLSGGEREITLKPKAIKAHPVLESNMLPYTQMSIYTQYTSPKNPIGVTPFQPTGGAFKS 1534
            .:..|.|.|.|...:: |.:|....|.......|..|.....|...|:.| ...|.||......:
Human   322 SSTAATPASAGHVWMS-KQQAPPPPPQQPPQAPPAPQAPPQPQAAPPQQP-AAPPQQPQAHTLTT 384

  Fly  1535 MPISPKGSGGKPEDAGSLQAHIKQEDIKQEPPSPYKLNNGSGSASGGGVVSAPPPNSGSVGAIFN 1599
            :...|         ..|.:.|||.|.:.   ||.|               |....:|....|...
Human   385 LSSEP---------GQSQRTHIKTEQLS---PSHY---------------SEQQQHSPQQIAYSP 422

  Fly  1600 FNVPTATALSQKQFHYPMHHP--HRSPTDLRAAHQ--ACVPSSPAGMGLGHAA-----NIATPPA 1655
            ||:|          ||...:|  .||..|. ..||  :...|..||.|.|..:     |.|..|.
Human   423 FNLP----------HYSPSYPPITRSQYDY-TDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQRPM 476

  Fly  1656 SAPAQIMGGGPA----------SQKMFFAMTHP 1678
            ..|.....|.|:          .|.::..:|.|
Human   477 YTPIADTSGVPSIPQTHSPQHWEQPVYTQLTRP 509

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cicNP_001262755.1 DUF4819 349..432 CDD:465014
HMG-box_CIC-like 1231..1308 CDD:438806 25/76 (33%)
SOX9NP_000337.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..67
Sox_N 22..94 CDD:463586
Dimerization (DIM). /evidence=ECO:0000305|PubMed:31194875 63..103 2/5 (40%)
PQA. /evidence=ECO:0000305|PubMed:31194875 63..103 2/5 (40%)
HMG-box_SoxE 104..178 CDD:438840 24/74 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 160..273 34/147 (23%)
Transactivation domain (TAM). /evidence=ECO:0000269|PubMed:31194875 224..307 21/108 (19%)
9aaTAD 1. /evidence=ECO:0000269|PubMed:31194875 275..284 2/8 (25%)
9aaTAD 2. /evidence=ECO:0000269|PubMed:31194875 290..298 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 330..415 23/113 (20%)
Transactivation domain (TAC). /evidence=ECO:0000269|PubMed:8640233 394..509 34/143 (24%)
9aaTAD 3. /evidence=ECO:0000269|PubMed:34342803 460..468 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 479..509 5/29 (17%)
Blue background indicates that the domain is not in the aligned region.

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