Protein Alignment cic and SOX5

DIOPT Version :10

• Sequence 1: NP_001262755.1
• Gene: cic / 53560
• FlyBaseID: FBgn0262582
• Length: 2150
• Species: Drosophila melanogaster
• Sequence 2: XP_011519134.2
• Gene: SOX5 / 6660
• HGNCID: 11201
• Length: 828
• Species: Homo sapiens
• Alignment Length: 1021
• Identity: 185/1021 - (18%)
• Similarity: 303/1021 - (29%)
• Gaps: 397/1021 - (38%)

  Fly   585 DYDSDDELKRVGIGYSPAA--GDLDTEKMSACSKRSSMQSRGSTSSLLDQRLTPRSHPATPSAIH 647
            |.|...|.:|:. ...||:  |:.|.| ::..:.|..::...|...           ||....:|
Human    68 DPDLPQEFERMS-SKRPASPYGEADGE-VAMVTSRQKVEEEESDGL-----------PAFHLPLH 119

  Fly   648 RSQATTPHRFKKGDIVESESGVRKKYNGKQWRRLCMLCTKESQRRGYCSRHLNQKGNTSALPSST 712
            .|....||                   .::::.:.:|..:....|...|:|...:.:.:.:.||.
Human   120 VSFPNKPH-------------------SEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSSF 165

  Fly   713 GPGRLLSDSRSSSKTQIDEDTSRDSETSPNYRVKGRYDQEETDAAAMLVSLSSSR---------S 768
            .|      ..||:..|..|:..|.|..|.:....|..::.:...|.::.:|...:         .
Human   166 AP------HNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPE 224

  Fly   769 ATPS--------YTSPVNHAGASPLNAIAHSPVNVSATHRQNFFTPIANQSQQQQQQQPVAVPLD 825
            .|||        :...:...|:.....|..:|.:::...||  ...:.||....::|...|
Human   225 ETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQ--LMGMINQLTSLREQLLAA---- 283

  Fly   826 SKWKTTPSPVLYNANNNSSNNNTSSSNNNNNSNWEVGSNSNTHVAATAAATSTVGAQPLPPQTTP 890
                           ::......:|.........|:.......:|.
Human   284 ---------------HDEQKKLAASQIEKQRQQMELAKQQQEQIAR------------------- 314

  Fly   891 VSLVMHAPPPQQQPLQQQHHHHQPPPPPPASLPAPSAPPTSGSSSSHNSVGHATSVIRISSSQQQ 955
                     .|||.|||||                                      :|:..|||
Human   315 ---------QQQQLLQQQH--------------------------------------KINLLQQQ 332

  Fly   956 HQQQQQHQQQAHPHVVVSGGQTFHPVIVDATQLSVPLPPTTVSFHQPNTPTSTAASVASMSQDKM 1020
            .||.|              ||               |||..:....|:..|..||     :|...
Human   333 IQQVQ--------------GQ---------------LPPLMIPVFPPDQRTLAAA-----AQQGF 363

  Fly  1021 LAKNG--YNAPWFKLLP-HMTPMSKASPAPVTPTLTTSASSYNVVMMQQQQQHQQLQQQQ----- 1077
            |...|  |.|......| .:.|.:.|:.|..||.|..        :..||....||...|
Human   364 LLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGP--------LQLQQLYAAQLAAMQVSPGG 420

  Fly  1078 -------------------QLQQQQQSPP-------QMPLNHNNNHLIVSAPLSSPGK------- 1109
                               ...:...|||       ..|||      :.:.|.:|.||
Human   421 KLPGIPQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLN------LSAKPKTSDGKSPTSPTS 479

  Fly  1110 -------------PLNCSMNDAKVAAAAAAA-------------AVANQRQKQQQEEPDDQ-LDD 1147
                         ||..|:..|..:.:|..:             |:...||.::|...:.| ||.
Human   480 PHMPALRINSGAGPLKASVPAALASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQVLDG 544

  Fly  1148 DVFETTTPGI-SANSKKQTAAMRLPTHNSNIRKLEE---CH----------DDGAAGAPATSAAK 1198
            .|....:.|: :..::|:...:...|....:::.||   .|          .||:||. :.|...
Human   545 KVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGV-SESRIY 608

  Fly  1199 RRSQSLSALQQQQQQQQQAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVS 1263
            |.|:                  |..:.:|   .|:|||||||:::|..|:.:.:..|:..|..:|
Human   609 RESR------------------GRGSNEP---HIKRPMNAFMVWAKDERRKILQAFPDMHNSNIS 652

  Fly  1264 KILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTSTATPGGKASGAAGTGD 1328
            ||||..|.|:...:|..|:|..:.:...|.:.:|::|:  |.|.|
Human   653 KILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKY--KPRPK-------------------- 695

  Fly  1329 AKQRLVSVDGSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEA-------- 1385
               |...|||.                                .|.|..|.:.....
Human   696 ---RTCLVDGK--------------------------------KLRIGEYKAIMRNRRQEMRQYF 725

  Fly  1386 -----------------PTTISMKGNGNGKLMKNELPSDE-------DEQMLVVEEEQQQQTVKK 1426
                             |..|:|.|     :....|||:.       :..|.|:   |....||.
Human   726 NVGQQAQIPIATAGVVYPGAIAMAG-----MPSPHLPSEHSSVSSSPEPGMPVI---QSTYGVKG 782

  Fly  1427 IDLHCRERVNDSDMDD---TPFDYRKQQPEANQRS-AEEHSTSGAN 1468
            .:.|.:|.:...|::.   ..:|..:..|:.:..| :|.|....||
Human   783 EEPHIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..432	CDD:465014
		HMG-box_CIC-like	1231..1308	CDD:438806	27/76 (36%)
SOX5	XP_011519134.2	HMG-box_EGL13-like	619..696	CDD:438848	29/104 (28%)