DRSC/TRiP Functional Genomics Resources

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Protein Alignment cic and cica

DIOPT Version :10

Sequence 1:NP_001262755.1 Gene:cic / 53560 FlyBaseID:FBgn0262582 Length:2150 Species:Drosophila melanogaster
Sequence 2:XP_003200581.2 Gene:cica / 560266 ZFINID:ZDB-GENE-060503-700 Length:2440 Species:Danio rerio


Alignment Length:2660 Identity:632/2660 - (23%)
Similarity:944/2660 - (35%) Gaps:911/2660 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 STPQQQQ----------PPQPRQH-----------PKKRKFDP--------------AELDKTEQ 136
            |:||:::          |..|::|           |.:....|              .:|.|||:
Zfish    27 SSPQEEKRETEEKTQISPTSPKRHISSNSDSSQEGPLRSSNSPEKEGIHSDGVLSIAVDLGKTEE 91

  Fly   137 HP---------QQQQQQQVSLQKQQKPAETTGNGDGLANGNQQHRMIVSCGAGAGNNSS------ 186
            ||         ........|......|:.:.......|...::......|....||.|:      
Zfish    92 HPGSFKSGGTQSDSNSSTTSASNSPNPSSSRKTATFKARVPKKKYTFEHCAGNHGNASTPSTPPQ 156

  Fly   187 NSSSSNN-----------SSHSSSDIKQQQ--------------------------QQRIIIASP 214
            :||||:|           ::|:..|.:.||                          :.|..::||
Zfish   157 SSSSSHNGTGTSQVPAASAAHTDPDGQSQQAEGNIAMYAHNNITGPTGRTASDCGERDRTSVSSP 221

  Fly   215 QHASGS-TYKQHVA------SGNNSHAATINHQQRTHTPTTAVYYQQQQQQQQQQQQQRFSFNS- 271
            |..|.: |..:|.|      ||::|.|    :.|:....:|::..|:             |.:| 
Zfish   222 QRCSSTDTASEHSADIEVTTSGHDSSA----NSQKPQAHSTSIPTQE-------------SLSSG 269

  Fly   272 ---------NNQQHLQEQHQQQQQQQSLLDLSE-WNNTRVLAKIQNNYAPGIIRHAQEASPDSIL 326
                     .||:.|..|..:         |.| |.:.|. ..:...:..|::|...| ...|:.
Zfish   270 LAGVLAKGLKNQRVLARQGPR---------LGEGWPHDRG-RDVSGVFRTGVVRRVSE-EHGSLE 323

  Fly   327 VEF---------------DSTDLGLLLYTDVLHQGRNHVILDASPP-MADITLDARVCVRQRVEG 375
            |:.               ||.||                ||||||| :|.:.:..|||:..:.:.
Zfish   324 VQLNGEKTICKYPFRVASDSVDL----------------ILDASPPGVAPVAIGTRVCIPFKGDD 372

  Fly   376 RGSGSF--VYVEGIITDINQ---ATKQYSVQLIGDEMATTKVVR-----------------RADL 418
            .||...  .|.||::|.::|   .:.||.|||..|.....|.:|                 |.:|
Zfish   373 EGSEGTRQWYREGVVTQVDQHPAVSCQYRVQLREDVSDERKEIRSEEDDGRAISAQAIWVSRQNL 437

  Fly   419 RLLQPPW---------------------WDELNE---------LTTSGGASAPASSAKRKVPAAG 453
            |||.|||                     |:|.::         ||..|          .|||   
Zfish   438 RLLVPPWDLEPPQAAEPEGDGRRVREREWEERDDMEVEQEVVRLTRPG----------YKVP--- 489

  Fly   454 AGAGTGAAGCEAMTVPSGNIVYPKTATGAPLSFVATRYDGKLPTAP--PTSSHQQAQQQ------ 510
                       ::..|   ::.|.|:.....|.:.|.....|...|  ....|::..|:      
Zfish   490 -----------SLLHP---VIVPYTSPHTSSSAINTAITSVLSVVPNRDWEHHREKNQERDLHRH 540

  Fly   511 LVKQEEYYR----------------TTATS------PFQTRPPLAGPSHGSEQVVQATQSHPQQY 553
            |.::.|..|                |.|..      |.|.||.|:.|::.|..:::.....|.  
Zfish   541 LERERERDRDDIEVSRLSQLRDGSITAAMDGKAQGVPSQNRPILSKPNYLSHPLLRGPPIAPH-- 603

  Fly   554 NGLADIVISPCSNGQHLKMQQQQQQSSRGYDDYDSDDELKRVGIGYSPAAGDLDTEKMSACSKRS 618
                 :.::|..|..|:.:                       |:..:..|..:.|.::......|
Zfish   604 -----LPLAPHPNHPHMLL-----------------------GLDSATGAAVISTPQLPPLPPSS 640

  Fly   619 SMQSRGSTSSLLDQRLTPRSH----PATPSAIHRSQATTP-----HRFKKGDIVESESGVRKKYN 674
            |..|       ||:..:..||    ..:.|:...|::.||     .::||||:|.:.:|:|||:|
Zfish   641 SRSS-------LDKTPSSSSHGVSGGGSGSSSSSSRSRTPLTAAQQKYKKGDVVCTPTGIRKKFN 698

  Fly   675 GKQWRRLCML--CTKESQRRGYCSRHLNQKGNTSALPSSTGPGR----------LLSDSRSSSKT 727
            ||||||||..  |:|||||||||||||:.:  |..:.:..|.||          |..|.|...:|
Zfish   699 GKQWRRLCSREGCSKESQRRGYCSRHLSMR--TKEMEAGGGVGRDRSGASSTGTLTPDLRLGGRT 761

  Fly   728 QID---EDTSRDS--------ETSPNY-----------RVKGRYDQEETDAAAMLVSLSSSRSAT 770
            ..:   :|.||||        ::.|..           |...|:|.:|.:||.|||||.||||.|
Zfish   762 SSEYDWDDNSRDSSEASSRGGDSRPRLVMTSLMPQELPRDLSRFDFDECEAANMLVSLGSSRSCT 826

  Fly   771 PSYTSPVNH-------------------AGASPLNA----IAHSPVNVSATHRQNFFTPIANQSQ 812
            ||: |||::                   |..||:.|    ....|.::|.|....  ||..::.:
Zfish   827 PSF-SPVSNQSPFSPAPSPSPTLFGFRPANFSPITAPSPLTPRRPRHLSGTKIPG--TPTTDRER 888

  Fly   813 QQQQQQPV-------AVPLD-SKWK-TTPSPVLYNAN----NNSSNNNTSSSNNNNNSNWEVGSN 864
            ......|.       .||:. ||.| ..|.|.:.:|:    ::...|:.|.|.|           
Zfish   889 HLSGIVPTFSTNLTFTVPMSPSKRKLDAPPPSMPSASDYVKSDPQLNDPSLSIN----------- 942

  Fly   865 SNTHVAATAAATSTVGAQPLPPQTTPVSLVMHAPPPQQQPLQQQHHHHQPPPPPPASLPAPSAPP 929
                    |||...:..|..|  |||.||..   |.|:....:........|||....|.|.:|.
Zfish   943 --------AAAFRVLSPQSQP--TTPSSLSF---PRQRSVTSRPSSSAASTPPPMLVSPTPPSPL 994

  Fly   930 TSGSSSSHNSVGHATSVI------------------RISSSQQQHQQQQQHQQQAHPHVVVSGGQ 976
            ....||........:.||                  |.||..::|.|...|.......|.::|..
Zfish   995 PQDPSSRRIVPLRDSPVIVRNPDVPLAKFSDSPLSRRASSCSREHSQTPHHAVGLQAPVPINGAT 1059

  Fly   977 T------FHP----VIVDATQLSVPLPP--------TTVSFHQPNTPTSTAASVA-SMSQDKMLA 1022
            |      .:|    |:|.::|...|:.|        |.::....|..|..|.::: |..:|:...
Zfish  1060 TNGAVLLRNPAPTLVLVTSSQSLAPVAPGYPTHSNSTALNVSTSNATTGPALAISGSGGKDQERK 1124

  Fly  1023 KNGYNA----------PWFKLLPHMTPMSKASPAPVTP-------TLTTSASSYNVVMMQQQQQH 1070
            .:..:|          | ..|||.:.|.....|||...       |:.|:....:|.:.......
Zfish  1125 SDAGSALPQPVACHPSP-TALLPLILPAESPHPAPRKDIIMGRPGTVWTNVEPRSVPVFAWHSLV 1188

  Fly  1071 QQLQQQQQLQQQQQSPPQMPLNHNN---------NHLIVSAPLSSPGKPLNC---SMNDAKVAAA 1123
            ..|:..|.....|.:..|..:|.:.         :..:...|....|.| :|   |..|..|   
Zfish  1189 PFLETSQTKMSTQPADGQTLVNQSKEPRCGVALVSEGLTDHPTPERGSP-SCPPPSAEDPPV--- 1249

  Fly  1124 AAAAAVANQRQKQQQEEPDDQLDDDVFETTTPGISANSKKQTAAMRLPTHNSNIRKLEECHDDGA 1188
                         ::|..|.:.:.|..:...||:..:|                           
Zfish  1250 -------------EREGGDSETESDADDLFLPGVVPDS--------------------------- 1274

  Fly  1189 AGAPATSAAKRRSQSLSALQQQQQQQQQAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKK 1253
              :|:.:..|||:||||||.:...::::            ...|||||||||||||:||.:||::
Zfish  1275 --SPSLNPVKRRTQSLSALPKDGDKKRE------------KDHIRRPMNAFMIFSKRHRALVHQR 1325

  Fly  1254 HPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKS-STSTATPG 1317
            ||||||||||||||||||||.|::|.:||:||..||:|||:.||:||||:|||||| |....|||
Zfish  1326 HPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFRAHPDWKWCNKDRRKSLSEGRGTPG 1390

  Fly  1318 GKASGAAGTGDAKQRLVSV-----DGSDSLEHDMC-PSTPGGSGSCGGQGISSDLQGDIIPLTID 1376
            .|        ||::|.||.     ..|...||... ||.......|.|:..:..||         
Zfish  1391 AK--------DARERSVSESTEPHSTSQGAEHKGAGPSWTSPPSDCHGRSPAGQLQ--------- 1438

  Fly  1377 NYNSTCDEAPTTISMKGN----GNGKLM------KNELPSDE---DEQMLVVEEEQQQQTVK--- 1425
            ...:....|..|:..:..    .:|.|.      :...||::   ||:.:|:.||.....::   
Zfish  1439 RPRAFSQSAVHTLERREKERELDSGSLFQARPLTRPRRPSEDVTSDEEHMVICEEGDDDVIEDSF 1503

  Fly  1426 ---KIDLHCRERVNDSDMDDTPFDYRKQQ--------------PEANQRSAEEHSTS-------G 1466
               .|||.|:|||.|||.::...|....:              |.||:.. :.|..:       |
Zfish  1504 AEGSIDLKCKERVTDSDDENEHADEADSKRTFTPVLHSSLTFTPTANKHE-DRHEENLAKKKKRG 1567

  Fly  1467 ANGQAI-NAPPL----SGGEREITLKPKAIKA--------HPVLES----NMLPYTQMSIYTQYT 1514
            ..|..: |..|.    .||..::.....:...        |....|    .|.|....::....|
Zfish  1568 LGGAELDNGGPKEGEGGGGGGQVPFHANSASVTHINSTLLHDAYHSQGTVRMAPTIVTNVVRPIT 1632

  Fly  1515 SPKNPIGVTPFQPTGG-AFKSMPISPK--------GSGG---------KPEDAGSLQAHI----- 1556
            |...||...|..  || |..::|:..|        |:||         ||...|||...:     
Zfish  1633 STPVPIASKPVD--GGVAVGTLPLDGKPKLLIGTGGAGGGGYFPSSSPKPSGQGSLVTGLVLGGT 1695

  Fly  1557 --KQEDIKQ-EPPSPYKLNNGSGSASGGGV------------VSAPPPNSGSVGAIFNFNVPTAT 1606
              .|..::. .||.|...|   |:.:...|            .|...|:.|.......:.:||..
Zfish  1696 FPNQPTVQLITPPHPTPCN---GAPNNNAVPLPLLHHQFLPATSITSPSGGKPVTQVQYILPTLP 1757

  Fly  1607 AL------SQKQFHYP---MHHPHRSPTDLRAAHQACVPSSPAGMGLGHAANIA----------- 1651
            |.      |.:|...|   :..|..:||.:..|:..   .|.||.|:.:|:..|           
Zfish  1758 AAANPNSPSTQQTQQPSSVLALPGATPTHVTLANGV---HSGAGQGIRYASVSAVGGVSPGGVQA 1819

  Fly  1652 --------------------TPP-----ASAPAQIMGGGPASQKMFFA----------------- 1674
                                |||     ...|..:..|.|.|:.:..|                 
Zfish  1820 QSPVLQSKMLVPMATVGTGSTPPQPISLVGPPLPVQNGAPGSKIIQIAPMPVVQTNVHPGGSVHT 1884

  Fly  1675 -----------------MTHPYTLL--------------------------------QRSHQPGT 1690
                             .|.|.|:|                                |::..|..
Zfish  1885 SSSFPVSMPTASVMAPGSTPPQTVLLTPPPTRITYVQSTPGVAAPLPLASTPAVSSTQQAPSPAG 1949

  Fly  1691 PS-----LEHLQLDAFAPGGYTLRNHNGLSSLPPPVSAQPTMLLHGYPPSHGVEPPARS------ 1744
            ||     :..|...|.||.|.||        :.|.|::||.:|....|||...:....|      
Zfish  1950 PSFLQSPVATLGFTAIAPAGQTL--------VQPIVASQPPLLAPCPPPSGLTQNTQASTATRQL 2006

  Fly  1745 -----PSYK------SMPSTPKSATYLMSAPPERGMDGGM-SGCASAAASGGDESDIDADGQQFI 1797
                 ||..      |:.:.|:|.:.|.|||......... ....|:..:....:..||..|..:
Zfish  2007 VTAIYPSVSLAGGVVSVTAMPQSTSSLTSAPASSSSSSSTPQAKTSSVTAAQTRTQTDAQPQSQV 2071

  Fly  1798 LAPTPAQLG---RAPLQRRKNLSQSK---------SESNVSFGANLGASNGQHI----SRKLHSP 1846
            ......:.|   |..::::::|..||         ||.:|..|.......|||.    ..|..|.
Zfish  2072 SMQMETERGPEARKEVEKQRDLLVSKDGLRAPPSGSEDSVQPGCTSITHKGQHCEGKEGGKKSSK 2136

  Fly  1847 TMMESSSPIIGHVNSSNLSSALPTPTSSTTTPNS-DEQLPLTPTTSSSNSNLNQQQPKSPMKGAP 1910
            |..|....:.|..:.|..:.|....:.:.|..|| ||:     ..|...|.|:  .|..|::   
Zfish  2137 TEREFEREVGGSSSQSERARAAEGESEAQTETNSKDEE-----AASKEKSVLD--PPPPPLQ--- 2191

  Fly  1911 GSTAAALK--------KKNDEMNNSVLKQVDFEKKYKALPQFQPED-CQSPSAIAVPSSPRVYGT 1966
            ..|.:|.|        |...:..:..|....||::.|.||:|:||| ..||:..::.:|||....
Zfish  2192 TDTPSAKKIKFRPPPLKSTTDSGDKALFGSSFEERLKELPEFKPEDVLPSPNLQSLATSPRAILG 2256

  Fly  1967 NYRKKNTAPPPVQKLMCEDDSIDEPASAPPTTTQRFFGPDFNNELKDERLAELESSDQTGRSPRT 2031
            :||||..            :|.|..::..||:.:|          |..||:...|.         
Zfish  2257 SYRKKRR------------NSTDLDSTDDPTSPRR----------KSRRLSSCSSE--------- 2290

  Fly  2032 PKTPLQSARSD---------ASEKGH-------------RKVLETRRSLVLQLFAEHGNFPTAQA 2074
            |.||..:|:.:         ..|..|             |::|:.||:||:|||.|||.||:|||
Zfish  2291 PNTPKSAAKCEGDIFTFDRTVGETEHILEELDRVPPSSLRRMLDQRRALVMQLFQEHGFFPSAQA 2355

  Fly  2075 TMAFQSKHSDVFPRKQDLQLKIREVRQKLLGQASCTPHSAG--------PNTPSDSNSSS 2126
            |.|||:::||.||.|..|||||||||||::..|..|..:.|        .:.|..||.:|
Zfish  2356 TAAFQARYSDTFPSKVCLQLKIREVRQKIMQTAGSTEITGGVAGGGSDSTSAPGPSNQAS 2415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cicNP_001262755.1 DUF4819 349..432 CDD:465014 36/135 (27%)
HMG-box_CIC-like 1231..1308 CDD:438806 57/76 (75%)
cicaXP_003200581.2 DUF4819 345..447 CDD:465014 36/117 (31%)
PHA03247 <858..1251 CDD:223021 87/436 (20%)
HMG-box_CIC-like 1303..1380 CDD:438806 57/76 (75%)
PHA03247 <1674..2209 CDD:223021 108/558 (19%)
Chi1 1735..>1951 CDD:442692 33/218 (15%)

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