Protein Alignment cic and pan

DIOPT Version :10

• Sequence 1: NP_001262755.1
• Gene: cic / 53560
• FlyBaseID: FBgn0262582
• Length: 2150
• Species: Drosophila melanogaster
• Sequence 2: NP_726528.2
• Gene: pan / 43769
• FlyBaseID: FBgn0085432
• Length: 1192
• Species: Drosophila melanogaster
• Alignment Length: 1531
• Identity: 276/1531 - (18%)
• Similarity: 457/1531 - (29%)
• Gaps: 585/1531 - (38%)

  Fly   535 PSHG-SEQVVQATQSHPQQY--NGLADIVISPCSNGQHL------------KMQQQQQQSSRGYD 584
            |..| :.|..|.|.:..:||  |.|..:.|.|.|....:            |:..|..|::...:
  Fly    48 PDGGFNNQYTQLTANKIEQYNCNDLDKVCIVPSSRSDGMEASFSELLLSPNKLISQPWQTAEEIE 112

  Fly   585 DYDSDDELKRVGIGYSPAAGDLDTEKMSACSKRSSMQSRGSTSSLLDQRLTPRSHPATPSAIHRS 649
            ::.:|                       :..:|:.|.|...|:|:|:|:      |.:...:..:
  Fly   113 NWQND-----------------------SFRQRNEMFSCIYTNSMLNQQ------PCSQQQLLAT 148

  Fly   650 QATTPHRFKKGDIVESESGVRK----KYNGKQWRRLC---MLCTKESQRRGYCSRHLNQKGNTSA 707
            |.... |..:..:.|.|....|    .|:|.:...|.   :|.|..||            .|.:.
  Fly   149 QLLYA-RLLRSQLAEREFHSNKFNMVHYSGSKKTMLREDELLSTPSSQ------------DNNNN 200

  Fly   708 LPSSTGPGRLLSD-------------------SRSSSKTQIDEDTSRDSETSPNYRVKGRYDQEE 753
            :       :|:.|                   .|:..|.:.|:......:...|......||.:.
  Fly   201 I-------KLIKDIENSISCVDPPLFEFSNVHQRAEQKNKQDDKNCYSPKLKSNKEALDGYDLQH 258

  Fly   754 T------------DAAAMLVSLSSSR-------SATPSYTSPVNHAGASPLNAIAHSPVNVSATH 799
            |            |....|.:||.|.       |...|:.. ||:...|.|.......:|.:...
  Fly   259 TCDFIREQKNILIDIKKKLDNLSDSSGKFRKRLSVRQSHIE-VNNGSNSALEESVRRQLNGNRKS 322

  Fly   800 RQNFFTPIANQSQQQQQQQPVAVPLDSKWKTTPSPVLYNANNNSSNNNTSSSNNNNNSNWEVGSN 864
            .:|....:..              |.::|.   |..||...:.......|..:....|
  Fly   323 IENLLEEVKR--------------LYNQWS---SAELYYVRSLQRLGLPSEEDGEYTS------- 363

  Fly   865 SNTHVAATAAATSTVGAQPLPPQTTPVSLVMHAPPPQQQPLQQQHHHHQPPPPPPASLPAPSAPP 929
            :.||.....||.:......||.:|..|                  |...|.....:.....||.|
  Fly   364 TPTHTIMALAAIALSNESILPQKTNAV------------------HSKIPDVESESDFFLTSAKP 410

  Fly   930 TSGSSSSHNSVGHATSVIRISSSQQQHQQQQQHQQQAHPHVVVSGGQTFHPVIVDATQLSVPLP- 993
            .:       .|.....:::::||...||.    ...:.||      :::...:....:.|...|
  Fly   411 KT-------LVEIEDIILQLASSVNMHQS----SSASTPH------ESYSDSVKSDCEESNSAPT 458

  Fly   994 ----PTTVSF-HQPNT-PTSTAASV----ASMSQDKMLAKNGYNAPWFKLLPHMTPMSKASPAPV 1048
                .|..:| |:.:. |.||||.:    ||:|...       |....:||      :.||
  Fly   459 CIWHSTRQTFRHKKDVEPCSTAAEIILEYASLSSSS-------NIETSRLL------TSAS---- 506

  Fly  1049 TPTLTTSASSYNVVMMQQQQQHQQLQQQQQLQQQQQSPPQMPLNHNNN-----HLIVSAPL---- 1104
              .||....:|||.                        .|:|:..|.|     ..||:.||
  Fly   507 --NLTDVTENYNVT------------------------TQLPIVFNYNRESSAESIVTDPLLVPE 545

  Fly  1105 --SSPGKPLNCSMNDAKVAAAAAAAAVANQRQKQQQEEPDDQLDDDVFET--------------- 1152
              ::|..|...|.:.......:....::..|:||:.....:.|..:.|::
  Fly   546 FSTAPSTPSTGSNSGCSTGMVSGIFGLSQNRRKQRLARHIETLTTNSFKSNAIRGNVDNEITNQL 610

  Fly  1153 -TTPGISANSKKQTAAMRLPTHN-----------------------SNIRKLEECHDDGAAGAPA 1193
             |:|.|.|          |||.|                       :|:.|...|...|.||:..
  Fly   611 KTSPSIRA----------LPTENVSHLITKTLSSANASLTAQELSITNLFKERLCALQGNAGSMK 665

  Fly  1194 TS-------------AAKRRSQSLSALQQQQQQQQQAGAAGTAAGQPANKKIRRPMNAFMIFSKK 1245
            |.             .:|.:..:|.|......|..::........:|   .|::|:||||::.|:
  Fly   666 TEIFPMIDAPYDLSIGSKTKHMNLEAKHTSNAQSNESKETTNDKKKP---HIKKPLNAFMLYMKE 727

  Fly  1246 HRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWK-------WCS 1303
            .|..|..:...:::..:::|||..|:.|..|::::|:|.|...:..|.:|:|.|.       ...
  Fly   728 MRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYGYVSK 792

  Fly  1304 KDRRKSSTSTATPGG----KASGAAGTGDAKQ-------------RLVSVDGSDSLEHDMCPSTP 1351
            |.:||...||...||    |.....|.....|             .:.:::|:.          |
  Fly   793 KKKRKKDRSTTDSGGNNMKKCRARFGLDQQSQWCKPCRRKKKCIRYMEALNGNG----------P 847

  Fly  1352 GGSGSC---GGQGISSDLQGDIIPLTIDNYNSTCDEAPTTISMKGNGNGKLMKNELPSDEDEQML 1413
            ...|||   .|..:|.|.:.|   ...|....:|..|..|             |:: .|||.:.|
  Fly   848 AEDGSCFDEHGSQLSDDDEDD---YDDDKLGGSCGSADET-------------NKI-EDEDSESL 895

  Fly  1414 VVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQPEANQRSAEEHSTSGANGQAINAPP-L 1477
                                                                   .|::.:|. |
  Fly   896 -------------------------------------------------------NQSMPSPGCL 905

  Fly  1478 SGGEREITLKPKAIKAHPVLESNMLPYTQMSIYTQYTSPKNPIGVTPFQPTGGAFKSMPISPKGS 1542
            ||                 |.|...|.|.||:       .:|:.:.....|...|
  Fly   906 SG-----------------LSSLQSPSTTMSL-------ASPLNMNANSATNVIF---------- 936

  Fly  1543 GGKPEDAGSLQAHIKQEDIKQEPPSPYKLNNGSGSASGG-GVVSAPPPNSGSVGAIFNFNVPTAT 1606
               |..:.:|......:...|:.|:   |.:.|||:||. ..:|..|..|.:|..:   ...|..
  Fly   937 ---PASSNALLIVGADQPTAQQRPT---LVSTSGSSSGSTSSISTTPNTSSTVSPV---TCMTGP 992

  Fly  1607 ALSQKQFHYPMHHPHRSPTDLRAAHQACVPSSPAGMGLGHAANIATPPASAPAQIMGGGPASQKM 1671
            .|...|....|       ...|.:|        .||||       :||      ::....:..:.
  Fly   993 CLGSSQERAMM-------LGNRFSH--------LGMGL-------SPP------VVSTSTSKSEP 1029

  Fly  1672 FFAMTHPYTLLQRSHQPGTPSLEHLQLDAFAPGGYTLRNHNGLSSLPPPVSAQPTMLLHGYPPSH 1736
            || ..||                            |:.|:        |:.|.|::
  Fly  1030 FF-KPHP----------------------------TVCNN--------PIFALPSI--------- 1048

  Fly  1737 GVEPPARSPSYKSMPSTPKSATYLMSAPPERGMDGGMSGCASAAASGGDESDIDADGQQFILAPT 1801
                ...|.:..|||:|.::..                        |.:..||:          .
  Fly  1049 ----GNCSLNISSMPNTSRNPI------------------------GANPRDIN----------N 1075

  Fly  1802 PAQLGRAPLQRR-KNLSQSKSESNVSFGANLGASNGQHISRKLHSPTMMESSSPIIG-HVNSSNL 1864
            |..:.:...:|. ||:...::..:.:..|:...|..||::              :.| |.|.|.|
  Fly  1076 PLSINQLTKRREYKNVELIEASESKTIVAHAATSIIQHVA--------------VNGYHANHSLL 1126

  Fly  1865 SSAL----PTPTSSTTTPNSDEQLPLTPTTSSSNSN 1896
            :|.|    ....:.|..||..||..|:.:..|.||:
  Fly  1127 NSNLGHLHHQLNNRTENPNRSEQTMLSVSNHSVNSS 1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..432	CDD:465014
		HMG-box_CIC-like	1231..1308	CDD:438806	23/83 (28%)
pan	NP_726528.2	HMG-box_TCF7-like	713..791	CDD:438812	22/77 (29%)