Protein Alignment cic and Sox15

DIOPT Version :10

• Sequence 1: NP_001262755.1
• Gene: cic / 53560
• FlyBaseID: FBgn0262582
• Length: 2150
• Species: Drosophila melanogaster
• Sequence 2: XP_061509362.1
• Gene: Sox15 / 3291495
• VectorBaseID: AGAMI1_010058
• Length: 901
• Species: Anopheles gambiae
• Alignment Length: 1075
• Identity: 212/1075 - (19%)
• Similarity: 338/1075 - (31%)
• Gaps: 396/1075 - (36%)

  Fly  1024 NGYNAPWFKLLPHMTPMSKASPAPVTPTLTTSASSYNVVMMQQQQQHQQLQQQQQLQQQQQSP-- 1086
            |.||:|..:...|                    .:|:..:...|||.||.|||||......||
Mosquito    14 NHYNSPQHQQSYH--------------------RNYDEYVHPMQQQQQQQQQQQQHNAAASSPLS 58

  Fly  1087 ----------PQMPLNHNNNHLIVSAPLSSPGKPL---NCSMNDAKVAAAAAAAAVANQRQKQQQ 1138
                      ||.|......:.::.:||.....||   |.|:..::....:::..::.......|
Mosquito    59 TLSQHGSMMAPQSPSMLGGTNGMMPSPLMQSHSPLLSSNASLLQSQSPLLSSSPLMSQYSPYHHQ 123

  Fly  1139 EEPDDQLDDDVFETTTPGISANSKKQTAAMRLPTHNSNIRKLEECHDDGAAGA----PATSAAKR 1199
            :.|                            :||    |...:|....|..|.    ..|:|...
Mosquito   124 DVP----------------------------MPT----ILPQDEPGGGGGGGGWGGYALTAAGPY 156

  Fly  1200 RSQ----SLSALQQQQQQ--QQQAGAAGTAAGQPANK--KIRRPMNAFMIFSKKHRKMVHKKHPN 1256
            :|:    :...|.|:|..  ...||..|...|..:.|  :|||||||||:::|..||.:..::|:
Mosquito   157 QSEFCASNYGVLHQRQAYGGPHGAGKLGPHGGLKSAKEARIRRPMNAFMVWAKVERKKLADENPD 221

  Fly  1257 QDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTSTATPGGKAS 1321
            ..|..:||:||:.|.:|.|:.:..|.|.|..::..|...||.:|:..: |||.:.:.|.|.|.|
Mosquito   222 LHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHPNYKYRPR-RRKHAKARAGPNGGA- 284

  Fly  1322 GAAGTGDAKQRLVSVDGSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAP 1386
            |:.|||      .|| |::|            .||..|..           ||::|      .:|
Mosquito   285 GSLGTG------ASV-GANS------------QGSAAGAN-----------LTVNN------SSP 313

  Fly  1387 TTISMKGNGNGKLMKNELPSDEDEQMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQ 1451
            :.::.   |:|                                       ||....:||.|
Mosquito   314 SELNY---GDG---------------------------------------DSSQRMSPFTY---- 332

  Fly  1452 PEANQRSAEEHSTSGANGQAINAPPLSGGEREITLKPKAIKAHPVLESNMLPYTQMSIYTQYTSP 1516
                    ..|..:|:| .|:|.|..|.                                  |..
Mosquito   333 --------NPHYYAGSN-NALNTPDSSP----------------------------------TQS 354

  Fly  1517 KNPIGVTPFQPTGGAFKSMPISPKGS---GGKPEDAGSLQAHIKQEDIKQEPP----SPYKLNNG 1574
            ..||.|   .||.|:.|...::...:   |..|.:..|     |.:|:....|    ||.:|...
Mosquito   355 PEPIAV---PPTVGSRKLAAVAAAAAANGGAVPANGDS-----KMDDVSSALPTPEMSPLELEKE 411

  Fly  1575 SGSASGGGVVSAPPPNSGSVGAIFN---------FNVPTATAL---------------------- 1608
            .|  .|||:.||   ::||...:.:         :.|.:...|
Mosquito   412 PG--FGGGLHSA---HAGSYDDLKSKQKLTYDGVYGVKSEQKLPATFQAHAYEHETHQSHQQQHH 471

  Fly  1609 --SQKQFHYPMHHPHRSPTDLRAAHQ--ACVPSSPAGMGLGHAANIATPPASAPAQIMGGGPASQ 1669
              .|:|.|...||.|         ||  |.|.....|.|.|.....|   .....|::.|....:
Mosquito   472 QQQQQQHHQSQHHHH---------HQQDALVKREYGGFGHGGEKRYA---YEGVGQLVNGSGLHE 524

  Fly  1670 K-------------------MFFAMTHPYTLLQRSHQPGTPSLEHLQLDAFAPGGYTLRNHNGLS 1715
            |                   |:...|:...|.|          .|:....:.|...|..:|..|.
Mosquito   525 KRNYLSVSSGSTTTTAMVNGMYVMCTNRSILDQ----------GHIVTGTYFPPLATSEDHQTLG 579

  Fly  1716 SLPPPVSAQ-PTMLLHGYPPSHGVEPPARSPSYKSMPSTPKSATYLMSAPPERGMDGGMSGCASA 1779
            :.....|:. ||.|......::|      |.:..:.|.|..:|...:.:      ..|:.| |..
Mosquito   580 TTTMTTSSHGPTHLSTNSNHNNG------SGNSNNSPGTAANAQSQLKS------SNGLLG-AGV 631

  Fly  1780 AASGGDESDIDADGQQFILAPTPAQLGRAPLQRRKNLSQSKSESNVSFGANLGAS---NGQHISR 1841
            :.:....|.|.....|.             ||:::...|.::.||....:..|.:   ||.
Mosquito   632 STANTQMSQISNSNAQH-------------LQQQQQQQQQQAISNEQLNSYYGTASLPNGT---- 679

  Fly  1842 KLHSPT---------MMESSSPIIGH----VNSSNLSSALPTPTSSTTTPNSDEQLPLTPTTSSS 1893
               .||         :|..|..|.|.    |:|.:|...|..|.|:......|
Mosquito   680 ---LPTYSYAYKDYGIMYESHSIPGQDVEGVDSRDLEKYLKYPDSNQNFNGYD------------ 729

  Fly  1894 NSNLNQQQPKSPMKGA------------PGSTAAALKKKNDEMNNSVLKQVDFEKKY-------- 1938
            :::.:|....||..|:            .|:..|....::........:|...:::.
Mosquito   730 SASYHQTAGSSPAGGSIYGLPQGEYYTYGGAVLAHQSPQHQAQQQQHQQQQQQQQQQQHQHQQSH 794

  Fly  1939 ------------KALPQFQPEDCQSPSAIAVPSSP 1961
                        :.:|:......|.|.:..:||:|
Mosquito   795 QLSLSANGGGGGQGIPKLSDVMLQGPGSHQLPSTP 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..432	CDD:465014
		HMG-box_CIC-like	1231..1308	CDD:438806	29/76 (38%)
Sox15	XP_061509362.1	None