Protein Alignment cic and Bbx

DIOPT Version :10

• Sequence 1: NP_001262755.1
• Gene: cic / 53560
• FlyBaseID: FBgn0262582
• Length: 2150
• Species: Drosophila melanogaster
• Sequence 2: XP_008766856.1
• Gene: Bbx / 303970
• RGDID: 1309769
• Length: 938
• Species: Rattus norvegicus
• Alignment Length: 1134
• Identity: 208/1134 - (18%)
• Similarity: 355/1134 - (31%)
• Gaps: 432/1134 - (38%)

  Fly  1175 SNIRKLEECHDDGAAGAPATSAAK------RRSQSLSALQQQQQQQQ-------------QAGAA 1220
            ||..|......:||...|.....:      ::....|..:::.::::             :....
  Rat     4 SNRNKDHSAEGEGAGKRPKRKCLQWHPLLAKKLLDFSEEEEEDEEEEDIDKVQLVEADGLEQDVG 68

  Fly  1221 GTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELA 1285
            .|...:...::.|||||||::|.|:||.:|.::||..|||..:|||.:||..|.|::|.:|.::|
  Rat    69 ETEDDESPEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKILADWWAVLDPKEKQKYTDMA 133

  Fly  1286 SSVKDAHFKLHPEWKWCSKDRR--KSSTSTATPGGKASGAAGTGDAKQRLVSVDGSDSLEHDMCP 1348
            ...|||..|.:|.::||....:  ||.|.|..|             :::|.:.. |||
  Rat   134 KEYKDAFMKANPGYRWCPTTNKPVKSPTPTVNP-------------RKKLWAFP-SDS------- 177

  Fly  1349 STPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAPTTISMKGNGNGKLMKNELP------SD 1407
                          |.||                   ||.        .|....|:|      :|
  Rat   178 --------------SRDL-------------------PTA--------KKAKTEEVPQLNFGMAD 201

  Fly  1408 EDE----QMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQPEANQRS-----AEEHS 1463
            ..:    .||::..|....|.:.....||..:::|             ||..|:|     ||..|
  Rat   202 PTQMGGLSMLLLAGEHALGTPEASSGTCRPDISES-------------PELRQKSPLFQFAEISS 253

  Fly  1464 TSGANGQAINAPPLSGGEREITLKPKAIKAHPVLESNMLPYTQMSIYTQYTSPKNPIGVT-PFQP 1527
            .:                           :||...|.....:.:..:.:.:|..:.:|.| |.:.
  Rat   254 RT---------------------------SHPDAPSKQCQASALFQFAEISSSTSQLGGTEPVKR 291

  Fly  1528 TGGA----FKSMPISPKG--------SGGKPEDAGSLQAHIK---QEDIKQEP--PSPYKLNNGS 1575
            .|.:    ...|.::.:|        :..|..|.|.::...|   :.|:|.|.  .:.::.....
  Rat   292 CGNSALFQLAEMCLASEGVKMEGTELTKSKDSDGGRIEEMEKGKEERDMKMEKTIETAFQAEAEF 356

  Fly  1576 GSASGGGVVSAPPPNSGSVGAIFNFNVPTATALSQKQFHYPMHHPHRSPTDLRAAHQACVPSSPA 1640
            |.::.|.:                                      |.|.|||...|.
  Rat   357 GKSAKGNI--------------------------------------REPKDLRDIEQL------- 376

  Fly  1641 GMGLGHAANIATPPASAPAQIMGGGPASQKMFFAMTHPYTLLQRSHQPGTPSLEHLQLDAFAPGG 1705
                 .:.|:.......|..........||.             ||              |....
  Rat   377 -----QSDNVMAIKVEDPKDSRKESDDDQKY-------------SH--------------FPDFS 409

  Fly  1706 YTLRNHNGLSSLPPPVSAQPTMLLHGYPPSHGV----EPPARSPSYK--------------SMPS 1752
            |:..:...:|.:|    ::...:.|    .||:    :|.|.:...|              :..|
  Rat   410 YSASSKIIISDVP----SRKDHMCH----PHGIMIIEDPTALNKPEKIKKKKKKNKLDRHGNDRS 466

  Fly  1753 TPKSATYLMSAPPERGMDGGMSGCASAAASGGDESDIDADGQQFILAPTPA---------QLGRA 1808
            |||.|                  |....:|   ||||::     ::....|         :||..
  Rat   467 TPKKA------------------CKKRQSS---ESDIES-----VMYTIEAVAKGDWGADRLGET 505

  Fly  1809 PLQRRKNLSQSKSESNVSFGANLGA--------SNGQHISRKLHSPTMMESSSPIIGHVNSSNLS 1865
            |.::.:..|..|       |..|.|        |..:.:|::..|....||..|     :..|:|
  Rat   506 PRKKVRTSSSGK-------GGILDAKPPKKKVKSKEKKVSKEKCSDITKESRPP-----DFLNIS 558

  Fly  1866 SALPTPTSSTTTPNSDEQLPLTPT----------------------TSSSNSNLNQQQPKSPM-- 1906
            ::...|..   .|.|.:..|||||                      |.:..|..:::..|..:
  Rat   559 ASKSVPGE---VPESMKAEPLTPTEDALPPSLPGQAKPEDSDCHRKTETCGSRKSERSCKGALYK 620

  Fly  1907 -------------------------------------------KGAPGSTAAALKKKNDEMNNSV 1928
                                                       .|..||.....|.:.|....|.
  Rat   621 TLVSEGMLTSLRANVDRGKRSSGKGNSSDHEGCWSEESWTFNQSGTSGSKKFKKKLREDSFLGSA 685

  Fly  1929 LKQVDFEKKYKALPQFQP----EDCQSPSAIAVPSSPRVYGT-------------NYRKKNTAPP 1976
            ....:||||:.:|||:.|    ..|     :::|...:..|.             ..:|||....
  Rat   686 KLDEEFEKKFNSLPQYSPITFDRKC-----VSIPRKKKKTGNMSSESTKASKGPFQSQKKNLFHK 745

  Fly  1977 PVQKL--MCEDDSIDEPASAPPTTTQRFFGPDFN--NELKDERLAELESSDQTGRSPRTPKTPLQ 2037
            .|.|.  ..|..::.|..|....:.::||....:  ..:..|.....|.:.:...:...|.||..
  Rat   746 IVSKYKHKKEKPNVPEKGSGDKWSHKQFFLDAIHPTEAIFSEDKNTTEPAYKVKNALSIPNTPEP 810

  Fly  2038 SARSD---ASEKGHRKVLETRRSLVLQLFAEHGNFPTAQATMAFQSKHSDVFPRKQDLQLKIREV 2099
            :|..:   .|:|  ||..:|:.:.:::  ...|....|..|:       |..|::| ||.::.:|
  Rat   811 TAMQEPLVGSQK--RKARKTKITHLVR--TADGRVSPAGGTL-------DDKPKEQ-LQRRLPKV 863

  Fly  2100 RQKLLGQASCT------PHSAGPNTPSDS 2122
            .:...|. :|:      |.|:.|..|:.|
  Rat   864 PETFCGD-NCSHTTVEEPRSSTPEMPAVS 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..432	CDD:465014
		HMG-box_CIC-like	1231..1308	CDD:438806	34/78 (44%)
Bbx	XP_008766856.1	HMG-box_HBP2	81..149	CDD:438805	32/67 (48%)
		DUF2028	191..322	CDD:430742	27/170 (16%)