Protein Alignment cic and HBP1

DIOPT Version :10

• Sequence 1: NP_001262755.1
• Gene: cic / 53560
• FlyBaseID: FBgn0262582
• Length: 2150
• Species: Drosophila melanogaster
• Sequence 2: NP_001231191.1
• Gene: HBP1 / 26959
• HGNCID: 23200
• Length: 524
• Species: Homo sapiens
• Alignment Length: 682
• Identity: 130/682 - (19%)
• Similarity: 220/682 - (32%)
• Gaps: 231/682 - (33%)

  Fly   696 SRHLNQ--KGNTSALPSSTGPGRLLSDSRSSSKTQIDEDTSRDSETSPNYRVKGRYDQEETDAAA 758
            |.|.|.  :..|:.:|::.....|:.|.|:|                      |..|..|
Human     6 SEHHNMVWEVKTNQMPNAVQKLLLVMDKRAS----------------------GMNDSLE----- 43

  Fly   759 MLVSLSSSRSATPSYTSPVNHA---GASPLNAIAHSPVNVSATHRQNFFTPIANQSQQQQQQQPV 820
             |:..:.:..::|.|.|...|.   ....|.|:...|.. |..::.:        |....|:.|
Human    44 -LLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQ-SGMYQLS--------SDVSHQEYP- 97

  Fly   821 AVPLDSKWKTTPSPVLYNANNNSSNNNTS----SSNNNNNSNWEVGSNSNTHVAATAAATSTVGA 881
                .|.|                |.|||    ::...|..:|             ....:.:..
Human    98 ----RSSW----------------NQNTSDIPETTYRENEVDW-------------LTELANIAT 129

  Fly   882 QPLPP--------QTTPVSLVMHAPPPQQQPLQQQHHHHQPPPPPPASLPAPSAPPTSGSSSSHN 938
            .|..|        :::||.::..:        :..|.:.:|||...:|...|:.|        |:
Human   130 SPQSPLMQCSFYNRSSPVHIIATS--------KSLHSYARPPPVSSSSKSEPAFP--------HH 178

  Fly   939 SVGHATSVIRISSSQQQHQQQQQHQQQAHPHVVVSGGQTFHPVIVDATQL----SVP-------L 992
            .....|.|        :|::.....:         .|......:.|...|    |.|       |
Human   179 HWKEETPV--------RHERANSESE---------SGIFCMSSLSDDDDLGWCNSWPSTVWHCFL 226

  Fly   993 PPTTVSFHQ------PNTPTSTAASVASMSQD-KMLAKNGYNAPWFKLLPHMTPMS--------K 1042
            ..|.:.||:      .:......|......:| :|....||.:...|||.|...:|        .
Human   227 KGTRLCFHKGSNKEWQDVEDFARAEGCDNEEDLQMGIHKGYGSDGLKLLSHEESVSFGESVLKLT 291

  Fly  1043 ASPAPVTPTLTTSASSYNVVMMQQQQQHQQLQQQQ-------QLQQQQQSPPQMPLNHNNNHLIV 1100
            ..|..|...|.|         ::.:..|....:.:       .|...|...|...::..:    |
Human   292 FDPGTVEDGLLT---------VECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEVHIGD----V 343

  Fly  1101 SAPLSSPGKPLNCSMNDAKV--------------AAAAAAAAVANQRQKQQQ-EEPDDQLDDDVF 1150
            ..|   ||.|...:.:|:.|              :|....:::|.||:.... ..|..|
Human   344 CLP---PGHPDAINFDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASLSCGGPGGQ------ 399

  Fly  1151 ETTTPGISANSKKQTAAMRLPTHNSNIRKLEECHDDGAAGAPATSAAKRRSQSLSALQQQQQQQQ 1215
            :....|.|.|                            .|:|.:|.....|....|::..
Human   400 DFARSGFSKN----------------------------CGSPGSSQLSSNSLYAKAVKNH----- 431

  Fly  1216 QAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQ 1280
               ::||.:....| |.:|||||||:|:||:|....:.:|.:|||.:|.|||:.|..:|.|::..
Human   432 ---SSGTVSATSPN-KCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRM 492

  Fly  1281 YHELASSVKDAHFKLHPEWKWCSKDRRKSSTS 1312
            |...|.::.:...:|:|:   |.|.:|.:|.|
Human   493 YTLEAKALAEEQKRLNPD---CWKRKRTNSGS 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..432	CDD:465014
		HMG-box_CIC-like	1231..1308	CDD:438806	29/76 (38%)
HBP1	NP_001231191.1	AXH	224..350	CDD:197779	26/141 (18%)
		HMG-box_HBP1	445..513	CDD:438804	27/70 (39%)