Protein Alignment cic and sox6

DIOPT Version :10

• Sequence 1: NP_001262755.1
• Gene: cic / 53560
• FlyBaseID: FBgn0262582
• Length: 2150
• Species: Drosophila melanogaster
• Sequence 2: XP_031755685.1
• Gene: sox6 / 100144640
• XenbaseID: XB-GENE-483934
• Length: 804
• Species: Xenopus tropicalis
• Alignment Length: 1044
• Identity: 187/1044 - (17%)
• Similarity: 326/1044 - (31%)
• Gaps: 365/1044 - (34%)

  Fly   513 KQEEYYRTT---ATSPFQTRPPLAGPSHGSEQVVQATQSHPQQYNGLADIVIS---PCSNGQHLK 571
            |::.:.|.:   |.|||..:      :.|.|::.....|  ::.|...|.:::   |.....|.|
 Frog    21 KEDPFLRMSSKQAASPFTCK------AEGEEEMTGDLAS--REMNECKDQIMASHLPLHPLNHNK 77

  Fly   572 MQQQQQQSSRGYDDYDSDDELKRVGIGYSPAAGDLDTEKMSACSKRSSMQSRGSTSSLLDQRLTP 636
            ...::.||.                :...||  |||.:.|.:...|...:| ....||..
 Frog    78 PHSEELQSL----------------VTTLPA--DLDWDSMISSQHRMDSES-NKLRSLYS----- 118

  Fly   637 RSHPATPSAIHRSQATTPHRFKKGDIVESESGVRKKYN-GKQWRRLCMLCTKESQRRGYCSRHLN 700
                      .|:.:|:||:..:|  ....|.:....| |...||
 Frog   119 ----------FRTSSTSPHKPDEG--ARERSDLMSSVNFGTPERR-------------------- 151

  Fly   701 QKGNTSALPSSTGPGRL--LSDSRSSSKTQIDEDTSRDSETSPNY--------RVKGRYD---QE 752
             ||:.:.:..|....:|  ::.|.....|.:::..|:|.:...:.        .:||..:   ::
 Frog   152 -KGSLADVVDSLKQKKLEEMTRSEQEDSTCVEKILSKDWKDKMDRLNTSELLGEIKGTPESLAEK 215

  Fly   753 ETDAAAMLVSLSSSRSATPSYTSPVNHAGASPLNAIAHSPVNVSATHRQNFFTPIANQSQQQQQQ 817
            |...:.|:..|.|.|....:.........||.:.. ....::::...::.    ||.|.||..||
 Frog   216 ERQLSTMITQLISLREQLLAAHDEQKKLAASQIEK-QRQQMDLARQQQEQ----IARQQQQLLQQ 275

  Fly   818 Q-----------------PVAVPLDSKWKTT-------------PSPVLYNANNNSSNNNTSSSN 852
            |                 |:.:|:....:.|             |..:.|...:|....
 Frog   276 QHKINILQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGLSYKPGDNYPMQ------ 334

  Fly   853 NNNNSNWEVGSNSNTHVAATAAATSTVGAQPLPPQTTPVSLVMHAPPPQQQPLQQQHHHHQPPPP 917
                           .:.:|.||.:..|..||..|.      ::|  .|...:|.......|..|
 Frog   335 ---------------FIPSTMAAAAASGLSPLQLQQ------LYA--AQLASMQVSPGAKIPTTP 376

  Fly   918 PPASLPAPSAPPTSGSSSSHNSVGHATSVIRISSSQQQHQQQQQHQQQAHPHVVVSGGQTFHPVI 982
            .||:.|...:|  :|..|....   .:.|.:|.....|                        |:.
 Frog   377 QPANAPGTLSP--TGMKSEKRG---TSPVAQIKDEAAQ------------------------PLN 412

  Fly   983 VDATQLSVPLPPTTVSFHQPNTPTSTAASVASMSQDKMLAKNGYNAPWFKLLPHMTPMSKASPAP 1047
            :.|.      |.|......|.:||.:...|:..|...:..|:|.                  |:|
 Frog   413 LSAR------PKTADPIKSPTSPTQSFFPVSKTSPVSLSNKSGI------------------PSP 453

  Fly  1048 VT-PTLTTSASSYNVVMMQQQQQ-----HQQLQQQQQLQQQQQSPP-----QMPLNHNNNHLIVS 1101
            :. |:|...:|..:..:...|..     .:..:.::|:|::|...|     ::|:|:...:
 Frog   454 IRGPSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQLLTPHSIDGKLPINNMGLN---- 514

  Fly  1102 APLSSPGKPLNCSMNDAKVAAAAAAAAVANQRQKQQQEE-----------PDDQLDDDVFETTTP 1155
                      ||..:...:.|......:.:...::...|           .|.:|...|.:.|.|
 Frog   515 ----------NCRSDKMLLDAVTGKICIRSAHTERTHFENLGPQLTGKPNEDGKLGPGVIDLTRP 569

  Fly  1156 GISANSKKQTAAMRLPTHNSNIRKLEECHDDGAAGAPATSAAKRRSQSLSALQQQQQQQQQAGAA 1220
                                         :|...||....|...|.                 ..
 Frog   570 -----------------------------EDVEGGATVVEARVYRD-----------------TR 588

  Fly  1221 GTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELA 1285
            |.::.:|   .|:|||||||:::|..|:.:.:..|:..|..:|||||..|.|:..::|..|:|..
 Frog   589 GRSSSEP---HIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMSNQEKQPYYEEQ 650

  Fly  1286 SSVKDAHFKLHPEWKWCSKDRRKSSTSTATPGGKASGAAGTGDAKQRL----------------- 1333
            :.:...|.:.:|.:|:..:.:|     |....||   ....|:.||.:
 Frog   651 ARLSKIHLEKYPNYKYKPRPKR-----TCIVDGK---KLRIGEYKQLMRSRRQEMRQFFTVGQQP 707

  Fly  1334 ---------VSVDGSDSLEHDMCPSTPGG--SGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAPT 1387
                     |...|:.|    |..:||..  :..|.....|.:   ..||:....|....|
 Frog   708 QIPISTPTGVVYPGTIS----MATTTPSPQMTSDCSSTSASPE---PSIPVIQSTYGMKLD---- 761

  Fly  1388 TISMKGNGNGKLMKNELPSDEDEQMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQP 1452
                    :|.|..|:|.:.|||.                     |..:|.: ||...||....
 Frog   762 --------SGSLGGNDLMNGEDEM---------------------EMYDDFE-DDPKSDYSSDN- 795

  Fly  1453 EANQ 1456
            |||:
 Frog   796 EANE 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..432	CDD:465014
		HMG-box_CIC-like	1231..1308	CDD:438806	25/76 (33%)
sox6	XP_031755685.1	HMG-box_EGL13-like	595..672	CDD:438848	26/79 (33%)