DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cic and sox10

DIOPT Version :10

Sequence 1:NP_001262755.1 Gene:cic / 53560 FlyBaseID:FBgn0262582 Length:2150 Species:Drosophila melanogaster
Sequence 2:NP_001093691.1 Gene:sox10 / 100101700 XenbaseID:XB-GENE-480304 Length:436 Species:Xenopus tropicalis


Alignment Length:423 Identity:95/423 - (22%)
Similarity:145/423 - (34%) Gaps:110/423 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  1225 GQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVK 1289
            |..:...::|||||||::::..|:.:..::|:..|..:||.||:.|..|....|..:.|.|..::
 Frog    83 GSKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNENDKRPFIEEAERLR 147

  Fly  1290 DAHFKLHPEWKWCSKDRRKSSTSTATPGG--KASGAAGTGDAKQRLVSVDGSDSLEH-DMCPSTP 1351
            ..|.|.||::|:..:.|:....:.....|  :|.|.|.:..|..:      :..|:| ...|.:.
 Frog   148 MQHKKDHPDYKYQPRRRKNGKPNPGEGDGSSEAEGGAASIQAHYK------NSHLDHRHGSPMSD 206

  Fly  1352 GGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAPTTISMKGNGNGKLMKNELPSDEDEQMLVVE 1416
            |.|....||.     .|...|.|          .|.|....|..:||         .|....:.|
 Frog   207 GNSEHSAGQS-----HGPPTPPT----------TPKTELQAGKSDGK---------RDGSRSLGE 247

  Fly  1417 EEQQQQTVKKIDL----HCRERVNDSDMDDTPFD-YRKQQPEANQRS-----AEEHSTSGANGQA 1471
            ..:.......:|:    | ....|....|...|| |......|...|     ...:..|||    
 Frog   248 GGKPHIDFGNVDIGEISH-DVMANMETFDVNEFDQYLPPNGHAGHPSHIGGYTSSYGLSGA---- 307

  Fly  1472 INAPPLSGGEREITLKPKA---IKAHPVLESNMLPYTQMSIYTQYTSPKN-------PIGVTPFQ 1526
                 |:.|       |.|   .|.||..:|.....|:.|..:.||...:       .:|:..: 
 Frog   308 -----LAAG-------PSAWALAKQHPQTDSKAQVKTESSSTSHYTEQPSTSQLTYTSLGLPHY- 359

  Fly  1527 PTGGAFKSMPISPKGSGGKPEDAGSLQAHIKQEDIKQEPPSPYKLNNGSGSASGGGVVS--APPP 1589
              |.||.|:        .:|           |.|.....||....::.|.::|.....|  .||.
 Frog   360 --GSAFPSI--------SRP-----------QFDYADHQPSSSYYSHSSQASSLYSAFSYMGPPQ 403

  Fly  1590 NSGSVGAIFNFNVPTATALSQK----QFHYPMH 1618
            .            |..||:|..    |.|.|.|
 Frog   404 R------------PLYTAISDSPSVAQSHSPTH 424

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cicNP_001262755.1 DUF4819 349..432 CDD:465014
HMG-box_CIC-like 1231..1308 CDD:438806 25/76 (33%)
sox10NP_001093691.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..55
Sox_N 12..79 CDD:463586
Dimerization (DIM). /evidence=ECO:0000250|UniProtKB:P56693 48..88 1/4 (25%)
HMG-box_SoxE 89..163 CDD:438840 24/73 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 145..183 8/37 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 195..257 17/85 (20%)
Transactivation domain (TAM). /evidence=ECO:0000250|UniProtKB:P56693 209..295 22/110 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..346 6/23 (26%)
Transactivation domain (TAC). /evidence=ECO:0000250|UniProtKB:P56693 327..436 27/132 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 413..436 4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.