DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ4 and RECQ4A

DIOPT Version :9

Sequence 1:	NP_652607.1	Gene:	RecQ4 / 53438	FlyBaseID:	FBgn0040290	Length:	1579	Species:	Drosophila melanogaster
Sequence 2:	NP_172562.2	Gene:	RECQ4A / 837636	AraportID:	AT1G10930	Length:	1188	Species:	Arabidopsis thaliana

Alignment Length:	1293	Identity:	279/1293 - (21%)
Similarity:	464/1293 - (35%)	Gaps:	382/1293 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 MNSSMNQKPDHLNHTPPASSQKSVAPKNKPPPSEQETDSDS------DSVVAESEEEQEPQE--- 416
            :||:...:    :|.|..  ||...|:.......:..:|.|      .|.|..:.|.|:|::
plant     2 INSNQMSR----SHLPEV--QKPRGPQTNWSEHAKALESSSSVTKFLSSNVLYALESQKPRDMAA 60

  Fly   417 --------------YRQLSKRRKIVSTASG-----KVEVAAPVEIPNKVEPETETFAQENPDFSA 462
                          :.|:||..:.:|:.|.     :..|..|:::..            |..:||
plant    61 RSIAFPSVNVHTLAHPQISKAWRALSSLSVNNTYLRPGVTPPIDVGT------------NDSYSA 113

  Fly   463 DEDQDATYV--------PENKKKDKAKRKQAAGKQKTTKPKAEPKPKTEKKAKVKAEKKPKAEKK 519
            .|...|..:        ...:....|......|:...:.|.:.|...     |:.|||.|:...:
plant   114 RERSTAKVISSTGGSVYSSTRPNLSAMNVSGTGRSFHSFPSSVPGDD-----KIVAEKFPRGNNE 173

  Fly   520 PRNS----------KKAIAVEPAPDPEEDERQ----PLNPEDLKYVLALEAGDITSVPRINVQDL 570
            .|.|          :|:......|..:.:.|:    .::.:|:     ||..|:..:    |.:.
plant   174 IRESEPSCTHLNGVEKSFGNSAFPAEQFESRKACLDDMDDDDI-----LENIDVDQI----VMEH 229

  Fly   571 EEADATAQRYIRTFAAGPNPGLSEGSNIRVDEKRAAARKKLEERIAAGKLNENFVTINIQKKKFV 635
            ..:.:|.|..:..|:....|         ||  |:|:|  |||.            .|:.
plant   230 YHSTSTPQPSVSNFSLRTPP---------VD--RSASR--LEEE------------CNLP----- 264

  Fly   636 RGKKSVNFSKYKKQQWRHKKRVAALSGPDMDMGGCDGGVLTCFQCGGVGHFAQQCKVKGDSLLPL 700
                                       |:: ...|..|:.... |.......:|.|   |.||.:
plant   265 ---------------------------PEL-CSNCSHGIKLGL-CPEASTHVEQMK---DVLLAI 297

  Fly   701 SAQLEEDPSPFPTLAEAQEMASQGAVVAHSRNISRLPQAANAAILQGDEL------NESEEDDQE 759
            |.:|.:|         |.:::..        .:.:|.|.......|..:|      .||::....
plant   298 SNELLDD---------ATDLSPD--------RVGQLRQERLRLKKQIQQLENHIRDKESQKSQFL 345

  Fly   760 SSGDEEVQQHPDP---NWSSDEMDVDFEA----------------LDAAVEAS----LSQPVSQE 801
            ||....:.|:..|   |:..|:...||.|                .|::....    .|.||.:|
plant   346 SSTATRIFQYETPKSTNYKMDQPQTDFRAHVSDQGRYACDSWNTPRDSSFSVDRYGLSSAPVERE 410

  Fly   802 KAASPIKTYVGHKIPEEFLKQAGLDTTASSSNRSQHGGVKPLYDLLPDGSVQDTTPEVLEALH-- 864
            :....|                 :|.|.:..:..:..           .|.:......||..:
plant   411 QYVPKI-----------------IDVTYTEGSNDKKW-----------SSREFPWTRKLEVNNKK 447

  Fly   865 MFGHTNFRKGQDRAIMRTLSGLSSLVTLSTGSGKSLCYQLPAYLYSRKVGAITLVISPLVSLMED 929
            :||:.:||..|...|..|:||....|.:.||.||||.|||||.:    .|.|||||||||||::|
plant   448 VFGNHSFRPNQREIINATMSGSDVFVLMPTGGGKSLTYQLPALI----CGGITLVISPLVSLIQD 508

  Fly   930 QV-----TGVPHFLRAHCLHTNQTAPQRMKIQQMI--ANGEIDILLVSPEAVVAGERATGFGAIL 987
            |:     ..:|    |..|.......:::||.|.:  .:.:..:|.|:||.|...:      ::|
plant   509 QIMNLLQANIP----AASLSAGMEWAEQLKIFQELNSEHSKYKLLYVTPEKVAKSD------SLL 563

  Fly   988 RQLPP------IAFACIDEAHCVSQWSHNFRPSYLMICKVLRKNLGVRTVLGLTATATLPTRVSI 1046
            |.|..      :|...||||||||||.|:|||.|..: .:|::......||.||||||...:..:
plant   564 RHLENLNSRGLLARFVIDEAHCVSQWGHDFRPDYQSL-GILKQKFPNIPVLALTATATASVKEDV 627

  Fly  1047 INHLGI--------SDGERGI-ISDIPLPDNLVLSVSKDENRDAALLQLLNSERFEPCQSIIIYC 1102
            :..||:        |.....: .|.:|.....:..:.|          .:....|:.|.  ||||
plant   628 VQALGLVNCVVFRQSFNRPNLWYSVVPKTKKCLEDIDK----------FIKENHFDECG--IIYC 680

  Fly  1103 TRRDECERIAGFIRTCVQDRREPTQDQTKKRKRVNWQAEPYHAGMPASRRRTVQKAFMSNELRIV 1167
            ..|.:||::                  :::.:....:|..||..|...:|..:|..:..:|:.|:
plant   681 LSRMDCEKV------------------SERLQEFGHKAAFYHGSMEPEQRAFIQTQWSKDEINII 727

  Fly  1168 VATIAFGMGINKPDIRAVIHYNMPRNFESYVQEIGRAGRDGLPSHCHLFLDAKGGDQSELRRHVY 1232
            .||:||||||||||:|.|||:::|::.|.|.||.|||||||..|.|.|:...  ||...::..:.
plant   728 CATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYYGY--GDYIRVKHMIS 790

  Fly  1233 SNSIDRHVIRKLLQKIFVPCSCDKEASKRTALPIPLEGDGPRVHMCPGHEIGFSVEKTVEMLDIP 1297
            ...:|:                                 .|   |..|:.   .|..:..:|:..
plant   791 QGGVDQ---------------------------------SP---MATGYN---RVASSGRLLETN 816

  Fly  1298 AENISTLLCYMELDPRWCISVLSSAYVMAKVISYGGPKYLKHAAKECPPLAMAIALQIRDKTFKE 1362
            .||:..::.|.|.:.. |...|...::..|..|       .:..|.|.....:.:|..:|.|
plant   817 TENLLRMVRYCENEVE-CRRFLQLVHLGEKFDS-------TNCKKTCDNCCSSQSLIDKDVT--- 870

  Fly  1363 DSNIIEFSVTDIAAGIG--WNSG----VVKYQLKDLEWVKVNGYPKRSPITVSFYDLGFRIKVPG 1421
               :|...:.::....|  ::|.    |.:..|..:  ||     |....|:.|:..|..:
plant   871 ---LITRQLVELVKQTGERFSSAHILEVYRGSLNQM--VK-----KHRHETLQFHGAGKHL---- 921

  Fly  1422 DFTESEIDNALDTLYTRSVKQERTQ-------LIQLQYVAHGLAAVAYSSCGQCCNADFPQD--- 1476
              ::.|:...|..|.|..:..|..:       :..|..|.:..|.:.:|. .|.....||..
plant   922 --SKIEVSRILHYLVTEDILVEDVRKSDMYGSVSSLLQVNNAKATILFSG-SQTIVMKFPSSVKV 983

  Fly  1477 --RGEQLKAIVRNYFANDYPQDLELEIEPSNVPDENIIDDVH--------ALINMYPD 1524
              ..:|.....:....::....|.|..|.:...|.|:..:::        ||:...||
plant   984 LKPSKQGATAAKGPLTSEKQSTLPLTTEDAPPKDVNLSANMYTALRKLRTALVKEAPD 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:421279
RecQ4	NP_652607.1	RecQ	864..>1218	CDD:223588	128/377 (34%)
RECQ4A	NP_172562.2	PLN03137	1..1188	CDD:215597	279/1293 (22%)
		DEAD	455..625	CDD:278688	71/184 (39%)
		HELICc	650..776	CDD:238034	50/155 (32%)
		RecQ_Zn_bind	781..858	CDD:292742	17/123 (14%)
		RQC	868..966	CDD:214936	21/116 (18%)
		Sec_Non_Glob	955..>1023	CDD:275213	13/68 (19%)
		HRDC	1025..1090	CDD:278967	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820