Protein Alignment RecQ4 and Recql

DIOPT Version :10

• Sequence 1: NP_652607.1
• Gene: RecQ4 / 53438
• FlyBaseID: FBgn0040290
• Length: 1579
• Species: Drosophila melanogaster
• Sequence 2: NP_001397235.1
• Gene: Recql / 19691
• MGIID: 103021
• Length: 664
• Species: Mus musculus
• Alignment Length: 709
• Identity: 177/709 - (24%)
• Similarity: 301/709 - (42%)
• Gaps: 168/709 - (23%)

  Fly   782 DFEALDAAVE--ASLSQPVSQEKA--ASPIKTYVGHKIPEEFLKQAGLDTTASSSNRSQHGGVKP 842
            :..|:|..::  ....|.:.|.|:  ...||.|:.....|   ..:.|||:.::.|:...    |
Mouse    17 ELHAIDIQIQELTERRQELLQRKSVLTGKIKQYLEDSSAE---ASSDLDTSPAAWNKEDF----P 74

  Fly   843 LYDLLPDGSVQDTTPEVLEALHMFGHTNFRKGQDRAIMRTLSGLSSLVTLSTGSGKSLCYQLPAY 907
            .:     |.|:|    ||:  ::|....||..|...|..|::.....:.:.||.||||||||||.
Mouse    75 WF-----GKVKD----VLQ--NVFKLQKFRPLQLETINVTMARKDIFLVMPTGGGKSLCYQLPAL 128

  Fly   908 LYSRKVGAITLVISPLVSLMEDQVTGVPHFLRAHCLHTNQTAPQRMK---IQQMIANGEIDILLV 969
            ...    ..||||.||:||||||:..:.....:..:....::.:.:|   .:.:..|.::.::.|
Mouse   129 CSD----GFTLVICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSQLKLIYV 189

  Fly   970 SPEAVVAGE-------------RATGFGAILRQLPPIAFACIDEAHCVSQWSHNFRPSYLMICKV 1021
            :||.:...:             |.||             |.:||.||.|||.|:|||.|..: .:
Mouse   190 TPEKIAKSKMFMSRLEKAYEAGRLTG-------------AAVDEVHCCSQWGHDFRPDYKAL-GI 240

  Fly  1022 LRKNLGVRTVLGLTATATLPTRVSIINHLGISDGER--------GIISDIPLPDNLVLSV----S 1074
            |::.....:::|||||||        ||: :.|.::        ...:....| ||...|    |
Mouse   241 LKRQFPNASLMGLTATAT--------NHV-LKDVQKILCVGKCLTFTASFNRP-NLFYEVRQKPS 295

  Fly  1075 KDENRDAALLQLLNSERFEPCQSIIIYCTRRDECERIAGFIRTCVQDRREPTQDQTKKRKRVNWQ 1139
            ..|:....:::|:|. |::. ||.||||..:.:.|:|                  |...:::...
Mouse   296 SAEDFTEDIVKLING-RYKG-QSGIIYCFSQKDSEQI------------------TISLQKLGIH 340

  Fly  1140 AEPYHAGMPASRRRTVQKAFMSNELRIVVATIAFGMGINKPDIRAVIHYNMPRNFESYVQEIGRA 1204
            |..|||.|....:..|...:.:|||::||||:||||||:|||:|.|||::|.::.|:|.||.|||
Mouse   341 AGTYHANMEPEDKTKVHTQWSANELQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRA 405

  Fly  1205 GRDGLPSHCHLFLDAKGGD--------------QSELRRHV-YSNSID---RHVIRKLLQKIFVP 1251
            |||...:.|.|:...  ||              |.:|...| |..::.   |.:|.:...:::..
Mouse   406 GRDDSRADCILYYGF--GDIFRISSMVVMENVGQQKLYEMVSYCQNVSKCRRVLIAQHFDEVWNA 468

  Fly  1252 CSCDKEASK----------------RTALPIPLEGDGPRVHMCPGHEIGFSVEKTVEMLDI---- 1296
            .:|:|....                |..:.|..:.:|....:.|...|...:.|....|.:
Mouse   469 DACNKMCDNCCKDVSFEKKNVTQHCRDLIKILKQAEGLNEKLTPLKLIDAWMGKGAAKLRVAGVV 533

  Fly  1297 ----PAENISTLLCYMELDPRWCISVLSSAYVMAKVISYGGPKYLKHAAKEC--PPLAMAIALQI 1355
                |.|::..::.:..|.     ..|...|   ...:|....|||...:.|  ...|.|:.:|:
Mouse   534 APALPREDLERIVAHALLQ-----QYLKEDY---SFTAYATISYLKVGPRACLLSNEAHAVTMQV 590

  Fly  1356 RDKTFKEDSNIIEFSVTDI-------AAGIGWNSGVVKYQL----KDLEWVKVNGYPKR 1403
            :    |...:.:..::::.       :.|...:||..:.|.    :.|.::||: :|::
Mouse   591 K----KSAQSSVRGALSEARQVEQVDSKGEEQSSGTARRQTASEGRPLYFLKVH-WPRQ 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:412085
		RecQ	855..>1216	CDD:440280	120/388 (31%)
Recql	NP_001397235.1	recQ_fam	81..543	CDD:129701	141/517 (27%)
		DEVH box	219..222		2/2 (100%)