DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ4 and Recql

DIOPT Version :9

Sequence 1:	NP_652607.1	Gene:	RecQ4 / 53438	FlyBaseID:	FBgn0040290	Length:	1579	Species:	Drosophila melanogaster
Sequence 2:	NP_001342440.1	Gene:	Recql / 19691	MGIID:	103021	Length:	648	Species:	Mus musculus

Alignment Length:	705	Identity:	173/705 - (24%)
Similarity:	294/705 - (41%)	Gaps:	169/705 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   782 DFEALDAAVE--ASLSQPVSQEKA--ASPIKTYVGHKIPEEFLKQAGLDTTASSSNRSQHGGVKP 842
            :..|:|..::  ....|.:.|.|:  ...||.|:.....|   ..:.|||:.::.|:...    |
Mouse    17 ELHAIDIQIQELTERRQELLQRKSVLTGKIKQYLEDSSAE---ASSDLDTSPAAWNKEDF----P 74

  Fly   843 LYDLLPDGSVQDTTPEVLEALHMFGHTNFRKGQDRAIMRTLSGLSSLVTLSTGSGKSLCYQLPAY 907
            .:     |.|:|    ||:  ::|....||..|...|..|::.....:.:.||.||||||||||.
Mouse    75 WF-----GKVKD----VLQ--NVFKLQKFRPLQLETINVTMARKDIFLVMPTGGGKSLCYQLPAL 128

  Fly   908 LYSRKVGAITLVISPLVSLMEDQVTGVPHFLRAHCLHTNQTAPQRMK---IQQMIANGEIDILLV 969
            ...    ..||||.||:||||||:..:.....:..:....::.:.:|   .:.:..|.::.::.|
Mouse   129 CSD----GFTLVICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSQLKLIYV 189

  Fly   970 SPEAVVAGE-------------RATGFGAILRQLPPIAFACIDEAHCVSQWSHNFRPSYLMICKV 1021
            :||.:...:             |.||             |.:||.||.|||.|:|||.|..: .:
Mouse   190 TPEKIAKSKMFMSRLEKAYEAGRLTG-------------AAVDEVHCCSQWGHDFRPDYKAL-GI 240

  Fly  1022 LRKNLGVRTVLGLTATATLPTRVSIINHLGISDGER--------GIISDIPLPDNLVLSV----S 1074
            |::.....:::|||||||        ||: :.|.::        ...:....| ||...|    |
Mouse   241 LKRQFPNASLMGLTATAT--------NHV-LKDVQKILCVGKCLTFTASFNRP-NLFYEVRQKPS 295

  Fly  1075 KDENRDAALLQLLNSERFEPCQSIIIYCTRRDECERIAGFIRTCVQDRREPTQDQTKKRKRVNWQ 1139
            ..|:....:::|:|. |::. ||.||||..:.:.|:|                  |...:::...
Mouse   296 SAEDFTEDIVKLING-RYKG-QSGIIYCFSQKDSEQI------------------TISLQKLGIH 340

  Fly  1140 AEPYHAGMPASRRRTVQKAFMSNELRIVVATIAFGMGINKPDIRAVIHYNMPRNFESYVQEIGRA 1204
            |..|||.|....:..|...:.:|||::||||:||||||:|||:|.|||::|.::.|:|.||.|||
Mouse   341 AGTYHANMEPEDKTKVHTQWSANELQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRA 405

  Fly  1205 GRDGLPSHCHLFLDAKGGD--------------QSELRRHV-YSNSID---RHVIRKLLQKIFVP 1251
            |||...:.|.|:...  ||              |.:|...| |..::.   |.:|.:...:::..
Mouse   406 GRDDSRADCILYYGF--GDIFRISSMVVMENVGQQKLYEMVSYCQNVSKCRRVLIAQHFDEVWNA 468

  Fly  1252 CSCDKEASK----------------RTALPIPLEGDGPRVHMCPGHEIGFSVEKTVEMLDI---- 1296
            .:|:|....                |..:.|..:.:|....:.|...|...:.|....|.:
Mouse   469 DACNKMCDNCCKDVSFEKKNVTQHCRDLIKILKQAEGLNEKLTPLKLIDAWMGKGAAKLRVAGVV 533

  Fly  1297 ----PAENISTL---------------------LCYMELDPRWCISVLSSAYVMAKVISYGGPKY 1336
                |.|::..:                     :.|:::.||.|: :.:.|:.:...:.......
Mouse   534 APALPREDLERIVAHALLQQYLKEDYSFTAYATISYLKVGPRACL-LSNEAHAVTMQVKKSAQSS 597

  Fly  1337 LKHAAKECPPLAMAIALQIRDKTFKEDSNIIEFSVTDIAAGIGWNSGVVKYQLKD 1391
            ::.|..|...:.     |:..|..::.|...:.|.:.:......|:|..|.:|.|
Mouse   598 VRGALSEARQVE-----QVDSKGEEQSSGNSQKSKSRLQPSGSKNAGAKKRKLDD 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:421279
RecQ4	NP_652607.1	RecQ	864..>1218	CDD:223588	119/381 (31%)
Recql	NP_001342440.1	recQ_fam	81..543	CDD:129701	141/517 (27%)
		DEVH box	219..222		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..648		11/52 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810