DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RecQ4 and rcq-5

DIOPT Version :9

Sequence 1:	NP_652607.1	Gene:	RecQ4 / 53438	FlyBaseID:	FBgn0040290	Length:	1579	Species:	Drosophila melanogaster
Sequence 2:	NP_001309439.1	Gene:	rcq-5 / 175522	WormBaseID:	WBGene00004322	Length:	821	Species:	Caenorhabditis elegans

Alignment Length:	902	Identity:	217/902 - (24%)
Similarity:	347/902 - (38%)	Gaps:	287/902 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   756 DDQESSGDEEVQQHPDPNWSS------------------------DEMDVDFEALDAAV------ 790
            ||.:...|:|.......|:::                        .|.:...:.|..|:
Worm    22 DDSDEETDKEPAAKKPSNYTAWAEIFNKKKTESSAVSAIEKAKKDSEKERQRQKLREAIMERKRR 86

  Fly   791 EASLSQPVSQEKAASPIKTY-----VGHKI---PEEFLKQAGLDTTASSSNR-SQHGGVKPLYDL 846
            ||.:::|..|:  ..|:.|.     |..||   .|:|      |.:..|::| :|...:.| .|.
Worm    87 EALMNEPKKQK--IEPVSTVKLEKSVNQKISANSEDF------DVSGPSNSRETQESPLDP-NDF 142

  Fly   847 LPDGSVQDTTPEVLEA-----------LHMFGHTNFRKGQDRAIMRTLSGL-----SSLVTLSTG 895
            :.:.....|...::..           |.:|.|..:|   .|..|:.::.:     ...|:|.||
Worm   143 VANPLAIGTGERLIRGQDIIERRDKVFLELFCHKKYR---SRLQMQAINCILKRKCDVYVSLPTG 204

  Fly   896 SGKSLCYQLPAYLYSRKVGAITLVISPLVSLMEDQVT-----GVPHFLRAHCLHTNQTAPQRMKI 955
            :||||||||||.::    |.||:|||||::||:||::     |:|    ...|::..|..:|.:|
Worm   205 AGKSLCYQLPAVVH----GGITVVISPLIALMKDQISSLKRKGIP----CETLNSTLTTVERSRI 261

  Fly   956 QQMIANGE--IDILLVSPEAVVA-GERATGFGAILRQLPPIAFACIDEAHCVSQWSHNFRPSYLM 1017
            ...:|..:  |.:|.::.|.|.. |.:....|...|.:  :.:..:||||||:||.|:|||.||.
Worm   262 MGELAKEKPTIRMLYLTAEGVATDGTKKLLNGLANRDV--LRYIVVDEAHCVTQWGHDFRPDYLT 324

  Fly  1018 ICKVLRKNLGVRTVLGLTATATLPTRVSIINHLGISDGER--------GIISDIPLPDNLVLSVS 1074
            :..:.....||..| .|||||....:..|...|.:.:.|.        .:..|:.:.|:|   .:
Worm   325 LGSLRDVCPGVPWV-ALTATANAKAQDDIAFQLKLRNPESFKSGTYRDNLFYDVAMRDHL---AT 385

  Fly  1075 KDENRDAALL-------------QLLNSERFEPCQ-------SIIIYCTRRDECERIAGFIRTCV 1119
            ..||..|:.:             .|...|:.|..|       |.|:||..|:||.::|
Worm   386 APENHMASFITKCLTVDAKTSSSNLTKHEKAERSQNKKTFTGSAIVYCRSRNECGQVA------- 443

  Fly  1120 QDRREPTQDQTKKRKRVNWQAEPYHAGMPASRRRTVQKAFMSNELRIVVATIAFGMGINKPDIRA 1184
                       |..:.....|..||||:....|..||:.:|:||:.:|.||:||||||:|||:||
Worm   444 -----------KMLEIAGIPAMAYHAGLGKKDRNEVQEKWMNNEIPVVAATVAFGMGIDKPDVRA 497

  Fly  1185 VIHYNMPRNFESYVQEIGRAGRDGLPSHCHLFLDAKGGDQSELRRHVYSNSIDRHVIRKLLQKIF 1249
            |||::..:|...|.||.|||||||..|:|.::...:  |::.|      |.:....:.||.:|
Worm   498 VIHWSPSQNLAGYYQEAGRAGRDGKRSYCRIYYSKQ--DKNAL------NFLVSGELAKLREK-- 552

  Fly  1250 VPCSCDKEASKRTALPIPLEGDGPRVHMCPGHEIGFSVEKTVEMLDIPAENISTLLCYMELDPRW 1314
                    |.|..|     ||                     |..::..::|.|.|
Worm   553 --------AKKNNA-----EG---------------------EKAEMQIKSIQTGL--------- 574

  Fly  1315 CISVLSSAYVMAKVISYGGPKYLKHAA-------KECPPLAMAIALQIRDKTFKEDSNIIEFSVT 1372
                       ||::.|......:|.:       .||.| ........||.| |...|:..|..:
Worm   575 -----------AKMLEYCESARCRHVSIASFFDDTECRP-CKTNCDYCRDPT-KTIRNVEAFINS 626

  Fly  1373 DIAAGIGW-----NSGVVKYQLKDLEWVKVNGYPKRSPITVSFYDLGFRIKVPGDFTESEIDNAL 1432
            :.:.|...     :||             .:|:.       |.|..|.|    |..||.|:.:|.
Worm   627 EASTGRSMFRKSASSG-------------ESGFD-------SVYGGGKR----GGETEDELLSAA 667

  Fly  1433 DTLYTRSVKQERTQLIQLQYVAHGLAAVAYSSCGQCCNADFPQDRGEQLKAIVRNYFAN-----D 1492
            .|......:.|                               |:..:::::::...||.     .
Worm   668 STSKDAMDRME-------------------------------QEEAKRVRSVISQEFAKRRQAAP 701

  Fly  1493 YPQDLELEIEPS---NV--PDENIIDDVHALINMYPDNTFTGRNIARIFHGIMSPNY 1544
            .|:.....:||:   ||  |::|:|.:|         ...|..|..|..|..:..|:
Worm   702 PPRATARRVEPATDVNVIKPEQNVIKNV---------TLETRENWVRFLHRALDSNW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RecQ4	NP_652607.1	RecQL4_SLD2_NTD	9..55	CDD:421279
RecQ4	NP_652607.1	RecQ	864..>1218	CDD:223588	130/394 (33%)
rcq-5	NP_001309439.1	DEAD	180..350	CDD:278688	64/180 (36%)
		RecQ	182..>617	CDD:223588	152/532 (29%)
		HELICc	<427..529	CDD:238034	50/119 (42%)
		RecQ_Zn_bind	558..610	CDD:292742	14/98 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820