Protein Alignment c11.1 and MROH9

DIOPT Version :10

• Sequence 1: NP_652606.1
• Gene: c11.1 / 53436
• FlyBaseID: FBgn0040236
• Length: 1742
• Species: Drosophila melanogaster
• Sequence 2: NP_001157101.1
• Gene: MROH9 / 80133
• HGNCID: 26287
• Length: 861
• Species: Homo sapiens
• Alignment Length: 961
• Identity: 189/961 - (19%)
• Similarity: 347/961 - (36%)
• Gaps: 256/961 - (26%)

  Fly   853 HKDQTIMSAILQTLLSICNQLIATKEQLPAPL---RHRKQIMETVFNIPIEAPFHDLPLLPTILK 914
            ||..:::.| ...|||..:.::|.......||   ..:.:|:|:.|.:.:.     :|.|..:.:
Human    26 HKVNSLLDA-YSGLLSNESMILAVNSSFVDPLLQFESQLKIIESSFGMLVV-----MPSLDKVKE 84

  Fly   915 LGTDFIRIGGPDTEEC------VDGGVIFEIACRNFFGCAQQLK-----MKFDSQEEDERNSFLA 968
            :|:.:..|  .|.|..      :...::..:..::.:. .|.||     |..||....||...:
Human    85 MGSSYEYI--EDMENLYHNILNIYENILTSLVSKDLYK-LQILKEMLVWMSKDSSYLQERIMVI- 145

  Fly   969 KHLNESLPQLNALVRAIVELDASPATLDLIIGILEGWTRDRNSEVRICASHVFNNTLDVYIKSMK 1033
              :|:.|......||..:.:||.      .:|:|.       :|:.:..||
Human   146 --INKVLRFTVTKVRKYISVDAP------CLGLLA-------AELSLLCSH-------------- 181

  Fly  1034 IGCEAPSKFNQTGQMLGK----IVPRCIDSNGTVRQVSVEILQKTLEIACIYETLTIASIDSTAD 1094
               |.||...|..  ||.    .:.||.:..||.:..:.:           ..:|...|.|
Human   182 ---EDPSIVKQAS--LGMCHLLYIARCQNDIGTNKPTNGK-----------SHSLQFPSSD---- 226

  Fly  1095 WLKEIETIKEHIITDEPKQIYNLAGDIAKIIALRISSFQYLQFCKTLLHSLRDPEQSSTIGASVV 1159
                :|.:.:....||.|        ||:.:...:.......|.::||..|..|:......|:.:
Human   227 ----VEFLPKEFQQDESK--------IAQRVGQTLLPPLLTDFVQSLLMKLSSPDDKIASDAASI 279

  Fly  1160 LKFFIQQKGSELFHA----IPDLVRDSLLALRVCEVPRAKSGVLKALVALTKHHPKLVCAEMLSQ 1220
            |.|.::      |||    :...:.|::.. ::|:....|..:|:.:..||...||.|..:::..
Human   280 LIFTLE------FHAEKVTMVSKIVDAIYR-QLCDNNCMKDVMLQVITLLTCTSPKKVIFQLMDY 337

  Fly  1221 PLPYDPNLVEYWHLVCNDPELTGLTLDNFLQLLSGASLQEGGQDASLSERQK----LASGQPFAI 1281
            |:|.|..|::.|...|:...:....|...|.:|.|   :.|..:.:::|.::    :.:..|.|.
Human   338 PVPADDTLIQMWKAACSQASVAPHVLKTILLILKG---KPGEMEDTVTEGKRFSLDITNLMPLAA 399

  Fly  1282 FCALHEMLPCKDIKGQLETRFADMFCMLLTSLSSYTNLAAPNPINNASLSPNQTQSGKTKFGFVP 1346
            ..||...||.    |......|..|..|||:|....       ..|:.|.|
Human   400 CQALCTFLPL----GSYRKAVAQYFPQLLTTLMFQV-------FYNSELKP-------------- 439

  Fly  1347 NKELIKLNPCQIALETFQAFLTNLEMEQIASVLTVNT---QLASSADWHNYIELLT--------- 1399
                |..:....|.:..:..|....::|:...|....   ||:....:::.:..:.
Human   440 ----ILKDRALYAQDALRVLLNCSGLQQVDITLMKENFWDQLSEDLCYYHGVCFIAKTLSEYNFP 500

  Fly  1400 --PMAIGLGQQLQLGSPQ-----------MRQLVNSLSK----------YVASPYDGQRVAAVGI 1441
              |..:....:|.:..|:           :.:|:|:..|          ::....|...|.:..|
Human   501 QFPETLSYLYKLSVEGPRRSEDTVIVLIFLTELLNNFFKDPLPEEFLVLFINWINDSNPVVSRLI 565

  Fly  1442 FSRLVPLKP----TGELAASILLHLGAALS-DPNAVVRG-LSIQGMGYVGQLGEKEAKRYS-ETA 1499
            ..|:|.:.|    |..:::.::..|.|.|| |.|.|::. |:::.:     |.|.:...|| .|.
Human   566 LHRIVHMSPIINKTENVSSILIAILDAFLSKDDNVVLQALLTLRRL-----LNELDKVTYSLGTR 625

  Fly  1500 IGALLKGVDDPVGDCLINIPLESMRGLSGILRALPSERVEPFHVSLAIRIRPFLGNYALEMREAA 1564
            ||:         ..|.:      |..::|.:|            |:|||   ..|....:||:..
Human   626 IGS---------SYCTL------MDHINGGIR------------SMAIR---HFGQLVRDMRQYT 660

  Fly  1565 IQLFGDICEGKHDDGSSSPTSSMEALREQLIANLFPLLLHLSESEVAIASACRGTLQRVCRLLTA 1629
            ..:...:.||                       |.||:|.|.:.:..:|.||:.|| ::|    .
Human   661 WMVNDVVLEG-----------------------LVPLILFLEDDDKRVAEACKYTL-KIC----T 697

  Fly  1630 PRVVEMAEQQLGEERGHQLNYS--SFVLEFVKTIALELTDHIQDFIDSCLPQLRSQWPEVRGSAA 1692
            .::.....:.|.:|     |||  ..||.....:.:...::|.|.....|..|.|....::.::.
Human   698 SQLKWSTSRLLKDE-----NYSFEMVVLNICNNLIISHRNYITDLTSDTLRFLWSPRTYLKRASV 757

  Fly  1693 IVIGIL-----HNFLSERNVQTETVASKIAVLLKDEQALVRMRAATALGYF 1738
            |:||.|     |..|.:   :.|.:...|..||:||..:::..|......|
Human   758 ILIGYLAKSGGHLLLRD---EIEVMLDVIERLLRDEDPMIKQLAEITYDIF 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
c11.1	NP_652606.1	None
MROH9	NP_001157101.1	HEAT 1	118..155		10/40 (25%)
		HEAT 2	252..289		10/42 (24%)
		HEAT 3	292..328		6/36 (17%)
		HEAT 4	357..394		6/39 (15%)
		HEAT 5	418..458		11/64 (17%)