Protein Alignment c11.1 and MROH5

DIOPT Version :10

• Sequence 1: NP_652606.1
• Gene: c11.1 / 53436
• FlyBaseID: FBgn0040236
• Length: 1742
• Species: Drosophila melanogaster
• Sequence 2: NP_997297.2
• Gene: MROH5 / 389690
• HGNCID: 42976
• Length: 1318
• Species: Homo sapiens
• Alignment Length: 1468
• Identity: 289/1468 - (19%)
• Similarity: 516/1468 - (35%)
• Gaps: 423/1468 - (28%)

  Fly   481 RFSKPSQ--EHGSQEEHANLVLSCENTLYMLASTVGTLDELLKRELLNYLILLDYTDICGNLAKC 543
            |:|.|:.  .|.||...|.|:|. |:.::|..:                     |:...|  .|.
Human    53 RWSHPTTILLHKSQSSQATLMLQ-EHRMFMGEA---------------------YSAATG--FKM 93

  Fly   544 LASLFAKSP-HIEYDIAGDDAATEQATPESMGAAGEDRSVIKRGKVMVPGA-----ETIY----- 597
            |..:.:..| |::|                         :||:.|.|..|:     |||:
Human    94 LQDMNSADPFHLKY-------------------------IIKKIKNMAHGSPKLVMETIHDYFID 133

  Fly   598 ------ARCLALLGNQQCIKRCSNIL------SFLRYYHPQVNPA--LEELWERKIPDLLLQINR 648
                  .....|....:.:...|::|      :|.|.....:..|  ||::::....::|:.|.|
Human   134 NPEISSRHKFRLFQTLEMVIGASDVLEETWEKTFTRLALENMTKATELEDIYQDAASNMLVAICR 198

  Fly   649 ESAYR--------QLL-----HDFVLETNEFLGGLDENFAQR-------------------LASK 681
            .| :|        :||     |..:|.....|...:|.|:|.                   |::.
Human   199 HS-WRVVAQHLETELLTGVFPHRSLLYVMGVLSSSEELFSQEDKACWEEQLIQMAIKSVPFLSTD 262

  Fly   682 LADQMYLYPMQLPHSEWHLPDLSAERGMLLQAVALTLLQVTDVACIHTKIDLIVTTARQERLDKH 746
            :..:..|:.:..|  .|...:.|.|:..|.....|.|....:.|.:...:..::.|:.|
Human   263 VWSKELLWTLTTP--SWTQQEQSPEKAFLFTYYGLILQAEKNGATVRRHLQALLETSHQ------ 319

  Fly   747 VKHADYEKRIEPCARALGYISRQHLGHLIKKLTELAQVGGRKHSTGFFSNLHFIKDTHKELENYK 811
                 :.|:.|..|..||..:.:||..:...|.:.    ||.....:  :|......:.|...:|
Human   320 -----WPKQREGMALTLGLAATRHLDDVWAVLDQF----GRSRPIRW--SLPSSSPKNSEDLRWK 373

  Fly   812 -SNLLVVKAFGRIMDEA--------DPLQS-----IQHLDEDDT-----------LLGFLIQQLA 851
             ::..::.|:|::..:|        |.:.|     ..:...|:|           |:|.:.:...
Human   374 WASSTILLAYGQVAAKARAHILPWVDNIVSRMVFYFHYSSWDETLKQSFLTATLMLMGAVSRSEG 438

  Fly   852 VHKDQTIM-SAILQTLL---------SICNQL------IAT---KEQLPAPLRHRKQIMETVFNI 897
            .|..:... |.:||.|:         ::|.:.      ||:   |.:.|..|..:.|::.|.|.
Human   439 AHSYEFFQTSELLQCLMVLMEKEPQDTLCTRSRQQAMHIASSLCKLRPPIDLERKSQLLSTCFR- 502

  Fly   898 PIEAPFHDLPLLPTILKLGTDFI-------------RIG------GPDTEECVDGGVIFEIACRN 943
                ....||||..:.|....|:             |.|      ||                |.
Human   503 ----SVFALPLLDALEKHTCLFLEPPNIQLWPVARERAGWTHQGWGP----------------RA 547

  Fly   944 FFGCAQQLKMKFDSQEEDERNSFLAKHLNESLPQLNALVRAIVELDASPATLDLIIGILEGWTRD 1008
            ...|::.|:..:                :.::..|:.::::::..:.:...|..::..|..|...
Human   548 VLHCSEHLQSLY----------------SRTMEALDFMLQSLIMQNPTADELHFLLSHLYIWLAS 596

  Fly  1009 RNSEVRICASHV---------FNNTLDVYIKSMKIGCEAPSK-FNQTGQMLGKIVPRCIDSNGTV 1063
            ..:..|..|.|.         .|..||            |.: |.:.||::|.:...|.|.:...
Human   597 EKAHERQRAVHSCMILLKFLNHNGYLD------------PKEDFKRIGQLVGILGMLCQDPDRAT 649

  Fly  1064 RQVSVEILQKTLEIACIYETLTIASIDSTADWLKEIETIKEHIITDEPKQIYNLAGD-------- 1120
            ::.|:|......::...::|......:|.|                 ||::.....|
Human   650 QRCSLEGASHLYQLLMCHKTGEALQAESQA-----------------PKELSQAHSDGAPLWNSR 697

  Fly  1121 -----------IAKIIALRISSFQYLQFCKTLLHSLRDPEQSSTI----------------GASV 1158
                       :||....::.|||.:   |.::..|...|.|..|                .||.
Human   698 DQKATPLGPQEMAKNHIFQLCSFQVI---KDIMQQLTLAELSDLIWTAIDGLGSTSPFRVQAASE 759

  Fly  1159 VLKFFIQQKGS--ELFHAIPDLVRDSLLALRVCEV--PRAKSGVLKALVALTKHHPKLVCAEMLS 1219
            :|...:|:.|:  |:..::...:|     ||:|.|  |:||...|.|:..|.:.|...:.|..|:
Human   760 MLLTAVQEHGAKLEIVSSMAQAIR-----LRLCSVHIPQAKEKTLHAITLLARSHTCELVATFLN 819

  Fly  1220 QPLPYDPNLVEYWHLVCNDPELTGLTLDNFLQLLSGASLQEGGQDASLSERQKLASGQPFAIFCA 1284
            ..:|.|.:..:.|..:......:.|.|...|..|....|..|..|:|...::|... :..|....
Human   820 ISIPLDSHTFQLWRALGAGQPTSHLVLTTLLACLQERPLPTGASDSSPCPKEKTYL-RLLAAMNM 883

  Fly  1285 LHEMLPCKDIKGQLETRFADMFCMLLTSLSSYTNLAAPNPINNASLSPNQTQSGKTKFGFVPNKE 1349
            |||:...::.|..::..:..:|..|||.:.....|..|:       .|...|..:.  ..||:.:
Human   884 LHELQFAREFKQAVQEGYPKLFLALLTQMHYVLELNLPS-------EPQPKQQAQE--AAVPSPQ 939

  Fly  1350 LIKLNPCQIALETFQAFLTNLEMEQIASVLTVNTQLASSADWHNYI--------ELLT-----PM 1401
                 .|..:||..::.                  |:::..||::.        ||.|     |.
Human   940 -----SCSTSLEALKSL------------------LSTTGHWHDFAHLELQGSWELFTTIHTYPK 981

  Fly  1402 AIGLGQQLQLGS------PQMRQLVNSLSKYVASPYDGQRVAAVGIFSRL----VPLKPTGELAA 1456
            .:||..:..:.:      ..:|||:.||.    ||.:.:|..|:.|.::.    |.|:...:.||
Human   982 GVGLLARAMVQNHCRQIPAVLRQLLPSLQ----SPQERERKVAILILTKFLYSPVLLEVLPKQAA 1042

  Fly  1457 SILLHLGAALSDPNAVVRGLSIQGMGYVGQLGEKEAKRYSETAIGALLKGVDDPVGD-------- 1513
            ..:|..|  |.||:..||.||:||:..:....:|          |:||:|...|:.|
Human  1043 LTVLAQG--LHDPSPEVRVLSLQGLSNILFHPDK----------GSLLQGQLRPLLDGFFQSSDQ 1095

  Fly  1514 ---CLINIPLESMRGLSGILRALPSERVEPFHVSLAIRIRPFLGNYALEMREAAIQLFGDICEGK 1575
               |:       |..:|..|..|.::......:.:||..|.|..:....:|.||:.||||:....
Human  1096 VIVCI-------MGTVSDTLHRLGAQGTGSQSLGVAISTRSFFNDERDGIRAAAMALFGDLVAAM 1153

  Fly  1576 HDDGSSSPTSSMEALREQLIANLFPLLLHLSESEVAIASACRGTLQRVCRLLTAPRVVEMAEQQL 1640
            .|       ..:..||.|:..::.||||||.:...|:|:..:.|..| |.:|...|::......|
Human  1154 AD-------RELSGLRTQVHQSMVPLLLHLKDQCPAVATQAKFTFYR-CAVLLRWRLLHTLFCTL 1210

  Fly  1641 GEERGHQLNYSSFVLEFVKTIALELTDHIQDFIDSCLPQLRSQWPEVRGSAAIVIG--ILHN--- 1700
            ..|||  |:...|:...:.|.:.|   .....:...|..|.|....::....:.||  |.::
Human  1211 AWERG--LSARHFLWTCLMTRSQE---EFSIHLSQALSYLHSHSCHIKTWVTLFIGHTICYHPQA 1270

  Fly  1701 -FLSERNVQTETVASKIAVLLKDEQALVRMRAATALGY 1737
             |.....|.|..:......|..|.:..:|..|.:.|.:
Human  1271 VFQMLNAVDTNLLFRTFEHLRSDPEPSIREFATSQLSF 1308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
c11.1	NP_652606.1	None
MROH5	NP_997297.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38
		HEAT 1	581..618		6/36 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..695		5/35 (14%)
		HEAT 2	769..811		14/46 (30%)
		HEAT 3	840..880		9/40 (23%)
		HEAT 4	996..1033		10/40 (25%)
		HEAT 5	1037..1074		13/38 (34%)
		HEAT 6	1076..1113		10/43 (23%)
		HEAT 7	1118..1155		11/36 (31%)
		HEAT 8	1164..1200		13/36 (36%)
		HEAT 9	1278..1315		7/31 (23%)