DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment c11.1 and Mroh7

DIOPT Version :9

Sequence 1:	NP_001285050.1	Gene:	c11.1 / 53436	FlyBaseID:	FBgn0040236	Length:	1742	Species:	Drosophila melanogaster
Sequence 2:	NP_001119959.1	Gene:	Mroh7 / 381538	MGIID:	2685873	Length:	1279	Species:	Mus musculus

Alignment Length:	986	Identity:	188/986 - (19%)
Similarity:	363/986 - (36%)	Gaps:	192/986 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   800 IKDTHKELENYKSNLLVVKAFGRIMDEADPLQSIQHLDEDDTLLGFLIQQLAVHKDQTIMSAILQ 864
            :|....|..|:.:...:|   ..|:......:.::..:|.:..:..:::|:......:::|...:
Mouse   374 VKVNEAEKRNHDNKAALV---ANIITYQKNQEMVEMKEEKEATVKMMMRQIQEEPLDSLLSPARR 435

  Fly   865 TLLSICNQLIATKEQLPAPLRHRKQIMET----VFNIP-IEAPFHDLPLLPTILKLGTDFIRIGG 924
            ..:.|..||..||..|  .:|.|.:::.|    ||::| ::|
Mouse   436 QAMEILAQLSHTKPIL--SVRERVELVNTCVRSVFSLPSVQA----------------------- 475

  Fly   925 PDTEECVDGGVIFEIACRNFFGCAQQLKMKFDSQEEDERNSFLAKHL-NESLPQLNALVRAIVEL 988
                                            .||:||..:.:.:.| .::|..|..|:.|:...
Mouse   476 --------------------------------MQEKDESKAEVIQILYYQTLDSLQKLLNALFIE 508

  Fly   989 DASPATLDLIIGILEGWTRDRNSEVRICASH----VFNNTLDVYIKSMKIGCEAPSKFNQTGQML 1049
            |.:|..|..|:..|..|.....:..|..|.:    |.|:||      :.:.....|.|...|.:|
Mouse   509 DPTPTGLKSILEPLGPWMNSGKAHERARAVNSNVSVLNHTL------VTLPFLISSGFPTLGLLL 567

  Fly  1050 GKIVPRCIDSNGTVRQVSVEILQKTLE-IACIYETLTIASIDSTADWLKEIETIKEHIITDEPKQ 1113
            |:::.|..|.:       .||.::.|: |..:|..|.:.......:     :|.|:.:..:..:.
Mouse   568 GRLLLRIGDPD-------EEIGREALDGITILYTILDLQKRTKNKE-----DTNKKELYENNKRF 620

  Fly  1114 I--YNLAG---DIAKIIALRISSFQYLQFCKTLLHSL------------RDPEQSSTIGASVVLK 1161
            :  ||...   :|.::|| ....|...|..:.||.:.            :|..:...:.:.|:|.
Mouse   621 LGPYNPVSPCQNILRVIA-EFGDFLGPQQVRDLLLAALEGLKGISETQGKDSGEMMQLASEVMLS 684

  Fly  1162 FFIQQKGSELFHAIPDLVRDSLLALRVCEVPRAKSGVLKALVALTKHHPKLVCAEMLSQPLPYDP 1226
            ..::.........||::::...:.|...:.|||:...|..:..|.......|...:|..|||.|.
Mouse   685 SVLEWYRHRALEVIPEIMQGIYMQLTHIQEPRAREVALLPISFLASSFMTEVVVALLMCPLPLDS 749

  Fly  1227 NLVEYW-HLVCNDPELTGLTLDNFLQLLSGASLQEGGQDASLSERQKLASGQ----PFAIFCALH 1286
            |..|.| .|:...|   ...:.:.|.||.          .||.|:.....|:    |.|....|.
Mouse   750 NGAEMWRQLILRKP---SCDVRDLLDLLL----------TSLKEKPVTKKGRASIVPLAAASGLC 801

  Fly  1287 EMLPCKDIKGQLETRFADMFCMLLTSLSSYTNLAAPNPINNASLSPNQTQSGKTKFGFVPNKELI 1351
            |:|......|::...:..:...||..:..:..|..|:.:.....|.:.||...    |:|.:.::
Mouse   802 ELLSVNSCVGRVRRIYPQLLLALLIQVHYHIGLNLPSRMAPRKDSKDDTQPPL----FIPVRWMV 862

  Fly  1352 KLNPCQIALETF---------QAFLTNLEMEQIASVLTVNTQLASSADWH-NYIELLTPMAIGLG 1406
            |:      ::|.         .|||.    ||      ...:|...|:.| ..:.||....:...
Mouse   863 KV------VKTLLLKMGCSYESAFLE----EQ------GGWELMGQAESHYRGVSLLARAMVHYS 911

  Fly  1407 QQLQLGSPQMRQLVNSLSKYVASPYDGQRVAAVGIFSRLVPLKPTGELAASILL-HLGAALSDPN 1470
            .|      ::.:::..|...:....:..::.|...|..|..::....:.....| .:...||..:
Mouse   912 CQ------ELCRILYLLIPLLERGDERHKITATAFFVELFRMEQVRRIPEEYSLGRMVEGLSHRD 970

  Fly  1471 AVVRGLSIQGMGYVGQLGEKEAKRYSETAIGALLKGVDDPVGDCLINIPLESMRGLSGILRALPS 1535
            .::..|||:|:..:....||.||  .::.:.:::|.:.:..|..::....:..|...|..:.|..
Mouse   971 PIMNVLSIRGLVILACKSEKMAK--VQSLLPSMVKSLKNMDGMLVVEAVHDLKRIFKGQGKKLTD 1033

  Fly  1536 ERVEPFHVSLAIRIRPFLGNYALEMREAAIQLFGDICEGKHDDGSSSPTSSMEALREQLIANLFP 1600
            ..|   :|.:...:.|...:....:|.:.|.::|.:.:       ...|...:|:.|||.:.|.|
Mouse  1034 SAV---YVEMLQILLPHFTDAREMVRASCINVYGKVVK-------KLQTPRTQAMEEQLTSTLMP 1088

  Fly  1601 LLLHLSESEVAIASACRGTLQRVCRLLTAPRVVEMAEQQLGEERGHQL---NYSSFVLEFVKTIA 1662
            ||..:.|....::..|..||  ||       .......:|.::...|.   |....|.:..|.:.
Mouse  1089 LLFIIQEGNAKVSQKCVKTL--VC-------CSSFMNWELPKKAYSQKPWDNQQLTVTKICKYLV 1144

  Fly  1663 LELTDHIQDFIDSCLPQLRSQWPEVRGSAAIVIGIL----HNFLSERNVQTETVASKIAVLLKDE 1723
            ....|::..|::..|...::....:|.|:.|.||.|    .|.::|..:  ..|.:.:.:|..|.
Mouse  1145 SSHRDNVFTFLNQSLEYAKNSRASLRKSSVIFIGSLVPCMENMMTEERL--NEVKATLEILRHDP 1207

  Fly  1724 QALVRMRAATA 1734
            :|.|.:.||.|
Mouse  1208 EASVCICAAQA 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
c11.1	NP_001285050.1	None
Mroh7	NP_001119959.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..145
		Chon_Sulph_att	26..>168	CDD:368978
		HEAT 1	913..950		5/42 (12%)
		HEAT 2	992..1029		6/38 (16%)
		HEAT 3	1035..1072		6/46 (13%)
		HEAT 4	1080..1117		13/45 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19783at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23120
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010