Protein Alignment c11.1 and MROH2B

DIOPT Version :10

• Sequence 1: NP_652606.1
• Gene: c11.1 / 53436
• FlyBaseID: FBgn0040236
• Length: 1742
• Species: Drosophila melanogaster
• Sequence 2: NP_775760.3
• Gene: MROH2B / 133558
• HGNCID: 26857
• Length: 1585
• Species: Homo sapiens
• Alignment Length: 1844
• Identity: 349/1844 - (18%)
• Similarity: 682/1844 - (36%)
• Gaps: 453/1844 - (24%)

  Fly    57 NIFDGLMDKEEQVRIAMQQAIVKILETHPERAAEILSEHRSQQPKMTDQTVAMLLDCIRRVVGAE 121
            |:..|:::||:.|.                  .|.:..|.:...:.||     :||
Human    16 NLTLGMLNKEDIVN------------------KEDIYSHLTSVIQNTD-----ILD--------- 48

  Fly   122 TPLPPAANQKLIDLALQELTKNPEHLPLIQNPAQRILVAIGRSSPESCEQVMEALQEKGTSTEGV 186
                .|..|:||..|.:::..| ..|..|:..|..:||::   :......||..:|......|..
Human    49 ----DAIVQRLIYYASKDMRDN-NMLREIRMLAGEVLVSL---AAHDFNSVMYEVQSNFRILELP 105

  Fly   187 AHFMLMQCLGLLATENPAGVVPHIKAILSRSQPHLVGIRQDHIKQAHAYAIGRFSEALLEESG-- 249
            ..|::: .|..|||...:..:|.:...|...|..|.....:.:|.....|:.:||:|:.:...
Human   106 DEFVVL-ALAELATSYVSQSIPFMMMTLLTMQTMLRLAEDERMKGTFCIALEKFSKAIYKYVNHW 169

  Fly   250 ------KKEEENCSTEISVAYDVLFNQWLHSREPKVCVEILQALS-SMYPLLPKDRIQDQAARLV 307
                  :.:....|.:|.:.:..:..:|.....|...:.|::|.. ::..||.::..:..|...|
Human   170 RDFPYPRLDANRLSDKIFMLFWYIMEKWAPLASPMQTLSIVKAHGPTVSLLLHREDFRGYALGQV 234

  Fly   308 PQILALYR-RSVDRNAVTQFLCSVLKTNLALNATVLDGIIDVLVTHLFDLVCVYPDYEKPQTVKG 371
            |.:|..|: :.:|.: |||.|..:|...:..:..:...:...:..:|...:|..|:   |...:.
Human   235 PWLLNQYKDKEIDFH-VTQSLKQILTAAVLYDIGLPRSLRRSIFINLLQQICRAPE---PPVKEN 295

  Fly   372 HYEVLRCFHLLAGHQPYSTRIMDTLLIHLRNNSERERMKSLLILTHLLNSCAGNIENRIPATIEC 436
            ..:...||.:||...|  ..:|:.....:|:|:|..|:..|.:|...:|:....:.:.| .:||.
Human   296 EMKASSCFLILAHSNP--GELMEFFDEQVRSNNEAIRVGILTLLRLAVNADEPRLRDHI-ISIER 357

  Fly   437 LKQLILSERGIKMKLTLLKTIVALAQKSHIRDKEFVWFVVRH--------SCRFSKP--SQEHGS 491
            ..::::.:...|::.::|..|..:.:||:|..:| .|.::.:        :....||  :..|.:
Human   358 TVKIVMGDLSTKVRNSVLLLIQTMCEKSYIEARE-GWPLIDYVFSQFATLNRNLEKPVKTNFHEN 421

  Fly   492 QEEHANLVLSCENTLYMLASTVGTLDELLKRELLNYLILLDYTDICGNLAKCLASLFAKSPHIEY 556
            ::|..::..:....|..|...|..:.::|...:|.:::..:||:....|...:..|.
Human   422 EKEEESVRETSLEVLKTLDPLVIGMPQVLWPRILTFVVPAEYTEALEPLFSIIRILI-------- 478

  Fly   557 DIAGDDAATEQATPESMGAAGEDRS-VIKRGKVMVPGAETIYARCL-----ALLGNQQCIKRCSN 615
                      .|..:...:|.|..: |:..|.|.:|..:.:.||.|     |.||.    .|.:.
Human   479 ----------MAEEKKQHSAKESTALVVSTGAVKLPSPQQLLARLLVISMPASLGE----LRGAG 529

  Fly   616 ILSFLRYYHPQVNPALEELWERKIPDL-----------------LLQINRESAYR--------QL 655
            .:..|:.....::|.|.:||:.::|:|                 |||:.:||.::        ||
Human   530 AIGLLKILPEIIHPKLVDLWKTRLPELLQPLEGKNISTVLWETMLLQLLKESLWKISDVAWTIQL 594

  Fly   656 LHDFVLETNEFLGGLDENFAQRLASKLADQMYLYPMQLPHSEWHLPDLSAERGMLLQAVALTLLQ 720
            ..||    .:.:|....|                              |.|:..|.:|:..||..
Human   595 TQDF----KQQMGSYSNN------------------------------STEKKFLWKALGTTLAC 625

  Fly   721 VTDVACIHTKIDLIVTTARQERLDKHVKHADYEKRIEPCARALGYISRQHLGHLIKKLTELAQVG 785
            ..|...::::|...:|...|        ..|..:.|   ...|||.:..||..::|.|...
Human   626 CQDSDFVNSQIKEFLTAPNQ--------LGDQRQGI---TSILGYCAENHLDIVLKVLKTF---- 675

  Fly   786 GRKHSTGFFSNLHFIKDTHKELENYKSNLL---VVKAFGRIMDEADPLQSIQHLDEDDTLLGFLI 847
              ::...||.|      ..|.|.:.|.:|.   |:..:|.:...|...|.:..|::|     .:.
Human   676 --QNQEKFFMN------RCKSLFSGKKSLTKTDVMVIYGAVALHAPKKQLLSRLNQD-----IIS 727

  Fly   848 QQLAVH-------------KDQTIMSAILQTLLSICNQLIATKEQ-------------------- 879
            |.|::|             ||..:..:..:::..|...:...::|
Human   728 QVLSLHGQCSQVLGMSVMNKDMDLQMSFTRSITEIGIAVQDAEDQGFQFSYKEMLIGYMLDFIRD 792

  Fly   880 -----LPAPLRHRKQI-------------METVFNIPIEAPFHDLPLLPTILKLGTDFIRIGGPD 926
                 |.:|:|.:..|             ::...||..|.....|||.|
Human   793 EPLDSLASPIRWKALIAIRYLSKLKPQLSLQDHLNILEENIRRLLPLPP---------------- 841

  Fly   927 TEECVDGGVIFEIACRNFFGCAQQLKMKFDSQEEDERNSFLAKHLNESLPQLNALVRAIVELDAS 991
                                 .:.||.:..:.::.|...||   ...|:..|..|::.::..:.:
Human   842 ---------------------LENLKSEGQTDKDKEHIQFL---YERSMDALGKLLKTMMWDNVN 882

  Fly   992 PATLDLIIGILE-------GWTRDRNSEVRICASHVFNNTLDVYIKSMKIGCEAPSKFNQTGQML 1049
            ......:..:|:       .|.|:|..::   .:.|..|.:           |||..| :.|.:|
Human   883 AEDCQEMFNLLQMWLVSQKEWERERAFQI---TAKVLTNDI-----------EAPENF-KIGSLL 932

  Fly  1050 GKIVPRCIDSNGTVRQVSVEILQKTLEIACIYETLTIASIDSTADWLKEIETIKEHIITDEPKQI 1114
            |.:.|...|:..|:||            |....|:.:..|......::.::.::|.:.:|:.:..
Human   933 GLLAPHSCDTLPTIRQ------------AAASSTIGLFYIKGIHLEVERLQGLQEGLESDDVQVQ 985

  Fly  1115 YNLAGDIAKIIALRISSFQYLQFCKTLLHSLRDPEQSSTIGASVVLKFFIQQKGSEL-------- 1171
            ..::..||||::..|.:.:.|.|.:.:|..|.....:.|....:.:...::|:|:.|
Human   986 IKISSKIAKIVSKFIPNEEILMFLEEMLDGLESLNPTCTKACGIWMITVLKQQGAALEDQLLEIL 1050

  Fly  1172 ---FHAIPDLVRDSLLALRVCEVPRAKSGVLKALVALTKHHPKLVCAEMLSQPLPYDPNLVEYWH 1233
               :|.:|        .||..|  .:...:|:|:..:...|...|...:|.:|||:|.:....|.
Human  1051 GTIYHHMP--------VLRQKE--ESFQFILEAISQIASFHMDTVVVNLLQKPLPFDRDTKTLWK 1105

  Fly  1234 LVCNDPELTGLTLDNFLQLLSGASLQEGGQDASLSERQKLASGQPFAIFCALHEMLPCKDIKGQL 1298
            .:...|..:|..|...:..|          :..|.:  .:|..:..::.||::|::   .:...:
Human  1106 ALAEKPASSGKLLQALIDKL----------ETELED--DIARVEAISVACAMYEVI---SMGTSV 1155

  Fly  1299 ETRFADMFCMLLTSLS---SYTNLAAPNPINNASLSPNQTQSGKTKFGFVPNKELIKLNPCQIAL 1360
            ...:.::|.:||..:|   ....|..|.......:...:.|.       :|       :||:::.
Human  1156 TGLYPELFTLLLKLVSCTLGQKMLTCPWSHRRHVMQQGEQQQ-------IP-------DPCRLST 1206

  Fly  1361 ETFQAFLTNLEMEQIASVL----TVNTQLASSADWH-NYIELLTPMAIGL-GQQLQLGSPQMRQL 1419
            .|.:........|.:|...    .:.|.|:|.:..| ....|...||:.. |..|.:    |.||
Human  1207 ATLKCLQAQAMREGLAKESDEGDNLWTLLSSPSTHHIGVCSLARSMAVWQHGVILDI----MEQL 1267

  Fly  1420 VNSLSKYVASPYDGQRVAAVGIFSRLVP---LKPTGELAASILLHLGAALSDPNAVVRGLSIQGM 1481
            ::||:    |..:..|:.....||.|:.   |...|.| .::|:.:..:..|.||.:|.::|:|:
Human  1268 LSSLT----SSSENYRITGAAFFSELMKEPILWKHGNL-RNVLILMDQSAWDSNATLRQMAIRGL 1327

  Fly  1482 GYVGQLGEKEAKRYSETAIGALLKGVDDPVGDCLINIPLESMRGLSGILRALPSERVEPFHVSLA 1546
            |........:.|::.:..:.::::|:   .......:..||::.|..||..|....|..:...:.
Human  1328 GNTASGAPHKVKKHKQLMLESIIRGL---YHLARTEVVCESLKALKKILELLTDRDVSFYFKEIV 1389

  Fly  1547 IRIRPFLGNYALEMREAAIQLFGDICEGKHDDGSSSPTSSME---ALREQLIANLFPLLLHLSES 1608
            ::.|.|..:...::|..||.||.|:          :|.:...   ...|::..:|...||||.:.
Human  1390 LQTRTFFEDEQDDVRLTAIFLFEDL----------APLTGRRWKIFFAEEIKKSLISFLLHLWDP 1444

  Fly  1609 EVAIASACRGTLQRVC--------------RLL--TAPRV--------VEMAEQQ---LGEERGH 1646
            ...|..|||..|. ||              |||  ..||.        |::|::.   |.....|
Human  1445 NPKIGVACRDVLM-VCIPFLGLQELYGVLDRLLDQDLPRARDFYRQFCVKLAKKNQEILWILHTH 1508

  Fly  1647 QLNYSSFVLEFVKTIALELTDHIQDFIDSCLPQLRSQWPEVRGSAAIVIGILHNFLSERNVQTET 1711
            ...:.:...|.:::.|::|||.:       :..|.||:.|:                   :..|.
Human  1509 SFTFFTSTWEVIRSAAVKLTDAV-------VLNLTSQYVEL-------------------LDREQ 1547

  Fly  1712 VASKIAVLLKDEQALVRMRAATAL 1735
            :.:::..|.:|....|:..|..||
Human  1548 LTTRLQALRQDPCISVQRAAEAAL 1571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
c11.1	NP_652606.1	None
MROH2B	NP_775760.3	HEAT 1	28..65		12/72 (17%)
		HEAT 2	228..263		11/35 (31%)
		HEAT 3	272..309		8/39 (21%)
		HEAT 4	310..346		9/37 (24%)
		HEAT 5	405..445		7/39 (18%)
		HEAT 6	531..569		7/37 (19%)
		HEAT 7	572..611		12/72 (17%)
		HEAT 8	662..699		11/48 (23%)
		HEAT 9	777..819		4/41 (10%)
		HEAT 10	964..1001		6/36 (17%)
		HEAT 11	1021..1059		6/45 (13%)
		HEAT 12	1112..1151		8/53 (15%)
		HEAT 13	1157..1195		6/37 (16%)
		HEAT 14	1258..1295		12/44 (27%)
		HEAT repeat	1306..1329	CDD:293787	6/22 (27%)
		HEAT repeat	1341..1374	CDD:293787	5/35 (14%)
		HEAT 15	1363..1402		9/38 (24%)
		HEAT repeat	1387..1424	CDD:293787	9/46 (20%)
		HEAT repeat	1433..1458	CDD:293787	10/25 (40%)