DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZFYVE1 and CG31064

DIOPT Version :9

Sequence 1:	NP_067083.1	Gene:	ZFYVE1 / 53349	HGNCID:	13180	Length:	777	Species:	Homo sapiens
Sequence 2:	NP_001287560.1	Gene:	CG31064 / 43277	FlyBaseID:	FBgn0051064	Length:	877	Species:	Drosophila melanogaster

Alignment Length:	110	Identity:	42/110 - (38%)
Similarity:	55/110 - (50%)	Gaps:	15/110 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   550 LKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDN 614
            ::|.....::||.|   .|||:..:    .:||.|       |..|.|:|....|..|...|...
  Fly   782 MQDQERRQRQLLSG---SAQSLQAM----PEAVGS-------PGIWAPDSIATHCTACEREFNLT 832

Human   615 DTKHHCRACGEGFCDSCSSKTRP-VPERGWGPAPVRVCDNCYEAR 658
            ..|||||:|||.||.:||..|.| :..:|....|||||||||.|:
  Fly   833 RRKHHCRSCGEIFCKACSEHTLPLLNAQGQPGKPVRVCDNCYAAK 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZFYVE1	NP_067083.1	GBP	174..410	CDD:206650
		Required for localization in the lipid droplets. /evidence=ECO:0000269\|PubMed:30970241, ECO:0000269\|PubMed:31293035	416..777		42/110 (38%)
		FYVE_like_SF	594..655	CDD:333710	28/61 (46%)
		FYVE_ZFYV1	711..771	CDD:277273
CG31064	NP_001287560.1	RUN	316..439	CDD:280855
		CASP_C	495..>634	CDD:285395
		FYVE_RUFY1_like	813..874	CDD:277261	28/60 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149908
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840