Protein Alignment ATP6V1C1 and VMA5

DIOPT Version :8

• Sequence 1: NP_001686.1
• Gene: ATP6V1C1 / 528
• HGNCID: 856
• Length: 382
• Species: Homo sapiens
• Sequence 2: NP_012843.1
• Gene: VMA5 / 853782
• SGDID: S000001563
• Length: 392
• Species: Saccharomyces cerevisiae
• Alignment Length: 392
• Identity: 139/393 (35%)
• Similarity: 215/393 (55%)
• Gaps: 46/393 (12%)

Human     7 ISAPGEKTCQQTWEKLHAATSKNNNL----AVTSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEG 67
            ::|||.||  .:|        .|..|    |..|.|.||:.|:|:||.|:..|:||:|:|..:..
Yeast    23 VTAPGSKT--DSW--------FNETLIGGRAFVSDFKIPEFKIGSLDTLIVESEELSKVDNQIGA 77

Human    68 VVKKVAQYMADVLEDSKDKVQENLLANGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQI 132
            .:.|:.:.:.. |.::.......|..|.:.:..|:..|||...|:.:.:|:|::..:|:...:|:
Yeast    78 SIGKIIEILQG-LNETSTNAYRTLPINNMPVPEYLENFQWQTRKFKLDKSIKDLITLISNESSQL 141

Human   133 DNDLKSRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDW 197
            |.|:::..:.||:.|.||...|||..|.|..|||.:|||.:||||:||:|.|:||.|||...:|:
Yeast   142 DADVRATYANYNSAKTNLAAAERKKTGDLSVRSLHDIVKPEDFVLNSEHLTTVLVAVPKSLKSDF 206

Human   198 IKQYETLAEMVVPRSSNVLSEDQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEEEMKADK 262
            .|.||||::.|||.|::|::||.:..|.||.||:|.|.:|...|||.|||.|:|.|:||.:...|
Yeast   207 EKSYETLSKNVVPASASVIAEDAEYVLFNVHLFKKNVQEFTTAAREKKFIPREFNYSEELIDQLK 271

Human   263 EEMNRLSTDKKKQFGPLVRWLKVNFSEAFIAWIHVKALRVFVESVLRYGLPVNFQAMLLQPNKKT 327
            :|.:..::.::.....|||..|..:.:.||.|.|:|||||:||||||||||.:|...::....|.
Yeast   272 KEHDSAASLEQSLRVQLVRLAKTAYVDVFINWFHIKALRVYVESVLRYGLPPHFNIKIIAVPPKN 336

Human   328 LKKLREVLHELYKHLDSSA-------------------AAIIDAPMDIPGLNLSQQEYYPYVYYK 373
            |.|.:..|.:.:..|..:|                   |:::|.            ||.|:|.|.
Yeast   337 LSKCKSELIDAFGFLGGNAFMKDKKGKINKQDTSLHQYASLVDT------------EYEPFVMYI 389

Human   374 ID 375
            |:
Yeast   390 IN 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1C1	NP_001686.1	V-ATPase_C	5..370	CDD:308707	136/386 (35%)
		3-helical coiled coil	56..76	CDD:270211	5/20 (25%)
		3-helical coiled coil	121..147	CDD:270211	6/26 (23%)
		3-helical coiled coil	275..306	CDD:270211	15/31 (48%)
VMA5	NP_012843.1	COG5127	6..392	CDD:227456	139/393 (35%)
		3-helical coiled coil	66..86	CDD:270211	5/20 (25%)
		3-helical coiled coil	130..156	CDD:270211	6/26 (23%)
		3-helical coiled coil	284..315	CDD:270211	15/31 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C34193984
eggNOG	1	0.900				E1_COG5127
Hieranoid	1	1.000
Homologene	1	1.000				H1281
Inparanoid	1	1.050	228	1.000	Inparanoid score	I827
Isobase	1	0.950		0	Normalized mean entropy	S922
OMA	1	1.010
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0001431
OrthoInspector	1	1.000				T1003900
orthoMCL	1	0.900				OOG5_127946
Panther	1	1.100			LDO	PTHR10137
Phylome	1	0.910		0.800	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R1630
TreeFam	1	0.960
	14	13.740