Protein Alignment ATP6V1C1 and Vha44

DIOPT Version :10

• Sequence 1: NP_001686.1
• Gene: ATP6V1C1 / 528
• HGNCID: 856
• Length: 382
• Species: Homo sapiens
• Sequence 2: NP_725565.3
• Gene: Vha44 / 36826
• FlyBaseID: FBgn0287825
• Length: 836
• Species: Drosophila melanogaster
• Alignment Length: 831
• Identity: 247/831 - (29%)
• Similarity: 316/831 - (38%)
• Gaps: 451/831 - (54%)

Human     1 MTEFWLISAPGEKTCQQTWEKLHAATSKNNNLAVTSKFNIPDLKVGTLDVLVGLSDELAKLDAFV 65
            |:|:|:|||||:||||||::.::..|||.:||....||:||||||||||.||||||:|.|||.:|
  Fly     2 MSEYWIISAPGDKTCQQTYDTMNNLTSKQHNLCNNYKFHIPDLKVGTLDQLVGLSDDLGKLDTYV 66

Human    66 EGVVKKVAQYMADVLEDSKDKVQENLLANG----------------------------------- 95
            |.:.:|||.|:.:||||.:||:.|||:||.
  Fly    67 EQITRKVANYLGEVLEDQRDKLHENLMANNSPGPPDDSMPCRHHQRIKHLSLRHQRKHQHTHHQN 131

Human    96 ----------------------------------------------------------------- 95
                                                                             
  Fly   132 KPQHYHHHHHHHQLPQDLKGKSAATCSPATPPAPASAPPHLPPACACDVLAPGSLTGGSLTNLST 196

Human    96 ----------------------------------------------------------------- 95
                                                                             
  Fly   197 SHEPEPEFDVCPCDECFACAPPSTSATASTLLADECYSQTASSMLSATRCALSTVAAIATGSGLG 261

Human    96 ----------------------------------------------------------------- 95
                                                                             
  Fly   262 NGPSTSAAAAAAASNSSGGGGGGGPASCSTLCSSAYFSTSAPTTSSSVHSSMSRSNSKRLNNNTC 326

Human    96 ----------------------------------------------------------------- 95
                                                                             
  Fly   327 SINNNKLSFRSGSHVSQLHLATQQPQHHHSHPHQQPHTNPLQSPVQKSMSEDEGDASNAHEDGET 391

Human    96 ----------------------------------------------------------------- 95
                                                                             
  Fly   392 DEDPKSPHSVQSDLSDAFDWWFNKPKRNSKKSSAQQQHETAQLQHQQTTQQHATPLTPQNHNQYQ 456

Human    96 ----------------------------------------------------------------- 95
                                                                             
  Fly   457 NQHLSKAMTFWHQASTTPRSSYRSFFNSLADQIYSKRSTPSQLNINNGFNLTPTHRSSPVSSCCG 521

Human    96 -----------------------VDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLK 137
                                   .:|..|:||||||||||||||||:||::||:|.:.|||.|||
  Fly   522 SSSQGRSSPDTDPAEPPEFPLSPAELPQYLTRFQWDMAKYPIKQSLRNIADIISKQIGQIDGDLK 586

Human   138 SRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDWIKQYE 202
            :::.|||||||||||||:|..||||||:||::|||:.|:||||||.||||:|||:..|||:..||
  Fly   587 TKSQAYNNLKGNLQNLEKKKTGSLLTRNLADLVKKEHFILDSEYLTTLLVIVPKVMANDWLTNYE 651

Human   203 TLAEMVVPRSSNVLSEDQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEEEMKADKEEMNR 267
            .:.:|:|||||.::.||.|..|.|||||:|..::|:..|||.|||||||.|||||:.|.|.||.:
  Fly   652 KITDMIVPRSSQLIQEDADYCLFNVTLFKKVAEEFKLHARERKFIVRDFVYNEEELAAGKNEMTK 716

Human   268 LSTDKKKQFGPLVRWLKVNFSEAFIAWIHVKALRVFVESVLRYGLPVNFQAMLLQPNKKTLKKLR 332
            |.||||||||||||||||||||||.|.||||||||||||||||||||||||:|::||||::|:||
  Fly   717 LMTDKKKQFGPLVRWLKVNFSEAFCALIHVKALRVFVESVLRYGLPVNFQAILIEPNKKSVKRLR 781

Human   333 EVLHELYKHLDSSAA--AIIDAP-MDIPGLNLSQQEYYPYVYYKIDCNLLE 380
            :||::||.|||.::|  |:..|. :|||||...|.||:|||:||::.:::|
  Fly   782 DVLNQLYGHLDGASAGGAVSSADNVDIPGLGFGQSEYFPYVFYKVNIDMVE 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1C1	NP_001686.1	V-ATPase_C	4..370	CDD:460851	240/816 (29%)
		3-helical coiled coil	56..76	CDD:270211	10/19 (53%)
		3-helical coiled coil	121..147	CDD:270211	14/25 (56%)
		3-helical coiled coil	275..306	CDD:270211	28/30 (93%)
Vha44	NP_725565.3	V-ATPase_C	5..>98	CDD:472803	56/92 (61%)
		3-helical coiled coil	57..77	CDD:270211	10/19 (53%)
		V-ATPase_C	<547..822	CDD:460851	184/274 (67%)
		3-helical coiled coil	570..596	CDD:270211	14/25 (56%)
		3-helical coiled coil	724..755	CDD:270211	28/30 (93%)