Protein Alignment ATP6V1C1 and Vha44

DIOPT Version :8

• Sequence 1: NP_001686.1
• Gene: ATP6V1C1 / 528
• HGNCID: 856
• Length: 382
• Species: Homo sapiens
• Sequence 2: NP_001137679.1
• Gene: Vha44 / 36826
• FlyBaseID: FBgn0262511
• Length: 836
• Species: Drosophila melanogaster
• Alignment Length: 831
• Identity: 247/832 (30%)
• Similarity: 316/832 (38%)
• Gaps: 451/832 (54%)

Human     1 MTEFWLISAPGEKTCQQTWEKLHAATSKNNNLAVTSKFNIPDLKVGTLDVLVGLSDELAKLDAFV 65
            |:|:|:|||||:||||||::.::..|||.:||....||:||||||||||.||||||:|.|||.:|
  Fly     2 MSEYWIISAPGDKTCQQTYDTMNNLTSKQHNLCNNYKFHIPDLKVGTLDQLVGLSDDLGKLDTYV 66

Human    66 EGVVKKVAQYMADVLEDSKDKVQENLLANG----------------------------------- 95
            |.:.:|||.|:.:||||.:||:.|||:||.
  Fly    67 EQITRKVANYLGEVLEDQRDKLHENLMANNSPGPPDDSMPCRHHQRIKHLSLRHQRKHQHTHHQN 131

Human    96 ----------------------------------------------------------------- 95
                                                                             
  Fly   132 KPQHYHHHHHHHQLPQDLKGKSAATCSPATPPAPASAPPHLPPACACDVLAPGSLTGGSLTNLST 196

Human    96 ----------------------------------------------------------------- 95
                                                                             
  Fly   197 SHEPEPEFDVCPCDECFACAPPSTSATASTLLADECYSQTASSMLSATRCALSTVAAIATGSGLG 261

Human    96 ----------------------------------------------------------------- 95
                                                                             
  Fly   262 NGPSTSAAAAAAASNSSGGGGGGGPASCSTLCSSAYFSTSAPTTSSSVHSSMSRSNSKRLNNNTC 326

Human    96 ----------------------------------------------------------------- 95
                                                                             
  Fly   327 SINNNKLSFRSGSHVSQLHLATQQPQHHHSHPHQQPHTNPLQSPVQKSMSEDEGDASNAHEDGET 391

Human    96 ----------------------------------------------------------------- 95
                                                                             
  Fly   392 DEDPKSPHSVQSDLSDAFDWWFNKPKRNSKKSSAQQQHETAQLQHQQTTQQHATPLTPQNHNQYQ 456

Human    96 ----------------------------------------------------------------- 95
                                                                             
  Fly   457 NQHLSKAMTFWHQASTTPRSSYRSFFNSLADQIYSKRSTPSQLNINNGFNLTPTHRSSPVSSCCG 521

Human    96 -----------------------VDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLK 137
                                   .:|..|:||||||||||||||||:||::||:|.:.|||.|||
  Fly   522 SSSQGRSSPDTDPAEPPEFPLSPAELPQYLTRFQWDMAKYPIKQSLRNIADIISKQIGQIDGDLK 586

Human   138 SRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDWIKQYE 202
            :::.|||||||||||||:|..||||||:||::|||:.|:||||||.||||:|||:..|||:..||
  Fly   587 TKSQAYNNLKGNLQNLEKKKTGSLLTRNLADLVKKEHFILDSEYLTTLLVIVPKVMANDWLTNYE 651

Human   203 TLAEMVVPRSSNVLSEDQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEEEMKADKEEMNR 267
            .:.:|:|||||.::.||.|..|.|||||:|..::|:..|||.|||||||.|||||:.|.|.||.:
  Fly   652 KITDMIVPRSSQLIQEDADYCLFNVTLFKKVAEEFKLHARERKFIVRDFVYNEEELAAGKNEMTK 716

Human   268 LSTDKKKQFGPLVRWLKVNFSEAFIAWIHVKALRVFVESVLRYGLPVNFQAMLLQPNKKTLKKLR 332
            |.||||||||||||||||||||||.|.||||||||||||||||||||||||:|::||||::|:||
  Fly   717 LMTDKKKQFGPLVRWLKVNFSEAFCALIHVKALRVFVESVLRYGLPVNFQAILIEPNKKSVKRLR 781

Human   333 EVLHELYKHLDSSAA--AIIDAP-MDIPGLNLSQQEYYPYVYYKIDCNLLE 380
            :||::||.|||.::|  |:..|. :|||||...|.||:|||:||::.:::|
  Fly   782 DVLNQLYGHLDGASAGGAVSSADNVDIPGLGFGQSEYFPYVFYKVNIDMVE 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1C1	NP_001686.1	V-ATPase_C	5..370	CDD:308707	241/816 (30%)
		3-helical coiled coil	56..76	CDD:270211	11/20 (55%)
		3-helical coiled coil	121..147	CDD:270211	15/26 (58%)
		3-helical coiled coil	275..306	CDD:270211	29/31 (94%)
Vha44	NP_001137679.1	V-ATPase_C	6..>98	CDD:301617	56/92 (61%)
		3-helical coiled coil	57..77	CDD:270211	11/20 (55%)
		V-ATPase_C	<547..822	CDD:281248	185/275 (67%)
		3-helical coiled coil	570..596	CDD:270211	15/26 (58%)
		3-helical coiled coil	724..755	CDD:270211	29/31 (94%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C34172314
eggNOG	1	0.900				E1_COG5127
Hieranoid	1	1.000
Homologene	1	1.000				H1281
Inparanoid	1	1.050	519	1.000	Inparanoid score	I1263
Isobase	1	0.950		0	Normalized mean entropy	S922
OMA	1	1.010
OrthoDB	1	1.010				D1016088at2759
OrthoFinder	1	1.000				FOG0001431
OrthoInspector	1	1.000				T609581
orthoMCL	1	0.900				OOG5_127946
Panther	1	1.100			LDO	PTHR10137
Phylome	1	0.910		0.800	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R1630
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	15	14.750