Protein Alignment ATP6V1C1 and vha-11

DIOPT Version :10

• Sequence 1: NP_001686.1
• Gene: ATP6V1C1 / 528
• HGNCID: 856
• Length: 382
• Species: Homo sapiens
• Sequence 2: NP_001023451.1
• Gene: vha-11 / 177017
• WormBaseID: WBGene00006920
• Length: 384
• Species: Caenorhabditis elegans
• Alignment Length: 378
• Identity: 213/378 - (56%)
• Similarity: 286/378 - (75%)
• Gaps: 4/378 - (1%)

Human     3 EFWLISAPGEKTCQQTWEKLHAATSKNNNLAVTSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEG 67
            |:||||.||||.....|:||:.:|   .|.:..||:.||||||||||.||||||:|:|||...|.
 Worm     8 EYWLISVPGEKGANDAWDKLNRST---GNTSTNSKYLIPDLKVGTLDQLVGLSDDLSKLDTSAEA 69

Human    68 VVKKVAQYMADVLEDSKDKVQENLLANGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQI 132
            |::|:.||..:|||:.|.|:.|||:....|:.||:|:|||:.||||:|||||.:||||.|.::||
 Worm    70 VIRKLVQYFTEVLEEDKSKIAENLVIGNKDMKTYVTKFQWEGAKYPLKQSLKVLSEIIGKQISQI 134

Human   133 DNDLKSRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDW 197
            |||||.::..|||||..|.:::||..|||||:.||::||.|||||:||||.|::|||||::..:|
 Worm   135 DNDLKVKSLTYNNLKNALASMDRKTVGSLLTKDLADLVKADDFVLNSEYLQTVIVVVPKISVKEW 199

Human   198 IKQYETLAEMVVPRSSNVLSEDQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEEEMKADK 262
            .::|.||:.||||.||.:|:|:.:..|..||||:|.:|:|::.|||||||||||.|:||.:||.:
 Worm   200 EQKYATLSSMVVPGSSKLLTEEGEHALYTVTLFKKVIDEFKNTARENKFIVRDFVYDEETLKAGR 264

Human   263 EEMNRLSTDKKKQFGPLVRWLKVNFSEAFIAWIHVKALRVFVESVLRYGLPVNFQAMLLQPNKKT 327
            .|.::|..:|::|:.||:||||:||.|.|.|:||:|||||||||||||||||||||.:::|.|..
 Worm   265 TERDKLMAEKQRQYAPLIRWLKINFGEIFAAYIHIKALRVFVESVLRYGLPVNFQAAVIEPAKGQ 329

Human   328 LKKLREVLHELYKHLDSSAAAIIDAPMDIPGL-NLSQQEYYPYVYYKIDCNLL 379
            .||||:.||:||.|||.|||..||...|.|.| :|...||||||::|::.:.|
 Worm   330 QKKLRQELHKLYIHLDGSAAGPIDTLEDSPALMSLGVNEYYPYVFFKLNIDFL 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1C1	NP_001686.1	V-ATPase_C	4..370	CDD:460851	208/366 (57%)
		3-helical coiled coil	56..76	CDD:270211	9/19 (47%)
		3-helical coiled coil	121..147	CDD:270211	15/25 (60%)
		3-helical coiled coil	275..306	CDD:270211	21/30 (70%)
vha-11	NP_001023451.1	V-ATPase_C	9..373	CDD:460851	208/366 (57%)
		3-helical coiled coil	58..78	CDD:270211	9/19 (47%)
		3-helical coiled coil	123..149	CDD:270211	15/25 (60%)
		3-helical coiled coil	277..308	CDD:270211	21/30 (70%)