Protein Alignment ATP6V1C1 and vha-11

DIOPT Version :8

• Sequence 1: NP_001686.1
• Gene: ATP6V1C1 / 528
• HGNCID: 856
• Length: 382
• Species: Homo sapiens
• Sequence 2: NP_001023451.1
• Gene: vha-11 / 177017
• WormBaseID: WBGene00006920
• Length: 384
• Species: Caenorhabditis elegans
• Alignment Length: 378
• Identity: 213/379 (56%)
• Similarity: 286/379 (75%)
• Gaps: 4/379 (1%)

Human     3 EFWLISAPGEKTCQQTWEKLHAATSKNNNLAVTSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEG 67
            |:||||.||||.....|:||:.:|   .|.:..||:.||||||||||.||||||:|:|||...|.
 Worm     8 EYWLISVPGEKGANDAWDKLNRST---GNTSTNSKYLIPDLKVGTLDQLVGLSDDLSKLDTSAEA 69

Human    68 VVKKVAQYMADVLEDSKDKVQENLLANGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQI 132
            |::|:.||..:|||:.|.|:.|||:....|:.||:|:|||:.||||:|||||.:||||.|.::||
 Worm    70 VIRKLVQYFTEVLEEDKSKIAENLVIGNKDMKTYVTKFQWEGAKYPLKQSLKVLSEIIGKQISQI 134

Human   133 DNDLKSRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDW 197
            |||||.::..|||||..|.:::||..|||||:.||::||.|||||:||||.|::|||||::..:|
 Worm   135 DNDLKVKSLTYNNLKNALASMDRKTVGSLLTKDLADLVKADDFVLNSEYLQTVIVVVPKISVKEW 199

Human   198 IKQYETLAEMVVPRSSNVLSEDQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEEEMKADK 262
            .::|.||:.||||.||.:|:|:.:..|..||||:|.:|:|::.|||||||||||.|:||.:||.:
 Worm   200 EQKYATLSSMVVPGSSKLLTEEGEHALYTVTLFKKVIDEFKNTARENKFIVRDFVYDEETLKAGR 264

Human   263 EEMNRLSTDKKKQFGPLVRWLKVNFSEAFIAWIHVKALRVFVESVLRYGLPVNFQAMLLQPNKKT 327
            .|.::|..:|::|:.||:||||:||.|.|.|:||:|||||||||||||||||||||.:::|.|..
 Worm   265 TERDKLMAEKQRQYAPLIRWLKINFGEIFAAYIHIKALRVFVESVLRYGLPVNFQAAVIEPAKGQ 329

Human   328 LKKLREVLHELYKHLDSSAAAIIDAPMDIPGL-NLSQQEYYPYVYYKIDCNLL 379
            .||||:.||:||.|||.|||..||...|.|.| :|...||||||::|::.:.|
 Worm   330 QKKLRQELHKLYIHLDGSAAGPIDTLEDSPALMSLGVNEYYPYVFFKLNIDFL 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1C1	NP_001686.1	V-ATPase_C	5..370	CDD:308707	209/366 (57%)
		3-helical coiled coil	56..76	CDD:270211	10/20 (50%)
		3-helical coiled coil	121..147	CDD:270211	16/26 (62%)
		3-helical coiled coil	275..306	CDD:270211	22/31 (71%)
vha-11	NP_001023451.1	V-ATPase_C	10..373	CDD:281248	209/366 (57%)
		3-helical coiled coil	58..78	CDD:270211	10/20 (50%)
		3-helical coiled coil	123..149	CDD:270211	16/26 (62%)
		3-helical coiled coil	277..308	CDD:270211	22/31 (71%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C34183727
eggNOG	1	0.900				E1_COG5127
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	437	1.000	Inparanoid score	I1019
Isobase	1	0.950		0	Normalized mean entropy	S922
OMA	1	1.010
OrthoDB	1	1.010				D1016088at2759
OrthoFinder	1	1.000				FOG0001431
OrthoInspector	1	1.000				T389724
orthoMCL	1	0.900				OOG5_127946
Panther	1	1.100			LDO	PTHR10137
Phylome	1	0.910		0.800	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R1630
TreeFam	1	0.960
	14	13.750