Protein Alignment PHB1 and Phb2

DIOPT Version :10

• Sequence 1: NP_002625.1
• Gene: PHB1 / 5245
• HGNCID: 8912
• Length: 272
• Species: Homo sapiens
• Sequence 2: NP_001097372.1
• Gene: Phb2 / 46038
• FlyBaseID: FBgn0010551
• Length: 338
• Species: Drosophila melanogaster
• Alignment Length: 267
• Identity: 135/267 - (50%)
• Similarity: 187/267 - (70%)
• Gaps: 9/267 - (3%)

Human     4 KVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFD 68
            ||..::|      |.|.| |:.:||.|:.||||:||.|..|:|..:..||.|..|||.|.|||:|
  Fly    26 KVLAAVG------AAAYG-VSQSLYTVEGGHRAIIFSRLGGIQSDIYSEGLHVRIPWFQYPIIYD 83

Human    69 CRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLPSITTEILKSVVAR 133
            .|||||.:...|||||||.:||:||:|.||.:..||.:...:|.||||:|||||..|:||||:|:
  Fly    84 IRSRPRKISSPTGSKDLQMINISLRVLSRPDSLNLPYLHKQLGVDYDEKVLPSICNEVLKSVIAK 148

Human   134 FDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARF 198
            |:|.:|||||:.||..:..:|.|||..|.:||||||||.|:||||:|.|:||||||||||:||.|
  Fly   149 FNASQLITQRQQVSLLIRKELVERARDFNIILDDVSLTELSFGKEYTAAIEAKQVAQQEAQRAVF 213

Human   199 VVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAG 263
            .||:|:|:|:..|:.|||:::||:::..:: ......::||||.||:.||..::.|:|..||.|
  Fly   214 FVERAKQEKQQKIVQAEGEAEAAKMLGLAV-KQNPAYLKLRKLRAAQSIARTIASSQNKVYLSA- 276

Human   264 QSVLLQL 270
            .|::|.:
  Fly   277 DSLMLNI 283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHB1	NP_002625.1	SPFH_prohibitin	27..221	CDD:259799	111/193 (58%)
Phb2	NP_001097372.1	SPFH_prohibitin	42..236	CDD:259799	111/193 (58%)