Protein Alignment PHB1 and CG14644

DIOPT Version :10

• Sequence 1: NP_002625.1
• Gene: PHB1 / 5245
• HGNCID: 8912
• Length: 272
• Species: Homo sapiens
• Sequence 2: NP_649445.3
• Gene: CG14644 / 40536
• FlyBaseID: FBgn0250821
• Length: 293
• Species: Drosophila melanogaster
• Alignment Length: 221
• Identity: 50/221 - (22%)
• Similarity: 99/221 - (44%)
• Gaps: 49/221 - (22%)

Human    51 GEGTHFLIPWVQKPIIFDCRSRPRNV---PVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGE 112
            |.|..||:|.:....:.|.|:|..::   .::|  :|:..::|. .:::..:.|.    |.::.:
  Fly    90 GPGVIFLVPCIDDLAVVDIRTRSFDLHRQEILT--RDMVTISID-GVVYYSIKSP----FDAMLQ 147

Human   113 DYDERVLPSITTEILKSVVARFDAG-----ELITQRELVSRQVSDDLTERAATFGLILDDVSLTH 172
            .||    |...||.|.....|..||     :|::.:|.:|.|:...|......:|:.:
  Fly   148 VYD----PEEATEKLAMTTLRNVAGTHKLMDLLSSKEYLSNQIEGILYNSTEPWGIRV------- 201

Human   173 LTFGKEFTEAVEAKQV-AQQEAERARFVVEKAEQQKKAAIISAEGD-------SKAAELI-ANSL 228
                    |.||.|:: ...:.:||..|.::|.::.||.:.:|:|:       .:||::: .|.:
  Fly   202 --------ERVEIKEIFMPDQLKRALAVEQEAMREAKAKVAAAQGERDAVTALKEAADIMETNPI 258

Human   229 ATAGDGLIELRKLEAAEDIAYQLSRS 254
            |      ::||.|:....|....:||
  Fly   259 A------LQLRYLQTLNSICNDDTRS 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHB1	NP_002625.1	SPFH_prohibitin	27..221	CDD:259799	40/185 (22%)
CG14644	NP_649445.3	SPFH_like	89..292	CDD:473137	50/221 (23%)