Protein Alignment CSAD and SecS

DIOPT Version :10

• Sequence 1: XP_054228176.1
• Gene: CSAD / 51380
• HGNCID: 18966
• Length: 652
• Species: Homo sapiens
• Sequence 2: NP_649556.3
• Gene: SecS / 40681
• FlyBaseID: FBgn0037347
• Length: 478
• Species: Drosophila melanogaster
• Alignment Length: 560
• Identity: 111/560 - (19%)
• Similarity: 181/560 - (32%)
• Gaps: 185/560 - (33%)

Human   145 PEEL--KQLLDLEL---RSQGESQKQILERCRAVIRYSVKTGHPRFFNQLFSGLDPHALAGRIIT 204
            ||:|  ...|.|.|   ||:..|.|::||:     |...|.|   :.::....| .|.||
  Fly     9 PEKLVPDNYLQLGLAAQRSKQRSFKELLEK-----RKLPKNG---WSDERIEEL-VHMLA----- 59

Human   205 ESLNTSQYTYEIAPVFVLMEEE--VLRKLRALVGWSSGDGIFCPG----------GS-----ISN 252
             ||:::.|.:::.    |.|.|  :..||.|...::.|.||...|          ||     ::|
  Fly    60 -SLDSNNYPHKVG----LGEREARIACKLVARRHYNFGHGIGRSGDLLEAQPKAAGSTLLARLTN 119

Human   253 MYAVNLARYQRYPDCKQRGLRTLPPLALFTSKEVGKRHRPNPGLLILISSQLSRDLPGLLPALPT 317
            ...::|.|....|.|  .|...:|.....|              |.|....|.:..||....|
  Fly   120 ALILDLIRGIGLPSC--AGCFLVPMCTGMT--------------LTLCLQSLRKRRPGARYVL-- 166

Human   318 SSKASLPPGGCASFQSRSVTTPSRRELRFWDLAPTVSEWSRLMREGKWSPRIWRGRLVWPRLRLT 382
                                                  |||:.::..:..
  Fly   167 --------------------------------------WSRIDQKSCFKA--------------- 178

Human   383 FHFFETFILDSGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVLLSQTHRH 447
                   |..:|.||.::..    .:.|  :.|....|:.:.....|.||     |:|...|...
  Fly   179 -------ITATGLVPVVIPC----LIKG--ESLNTNVDLFREKIKSLGVD-----SILCLYTTTS 225

Human   448 LLDGIQRADSVA--------WN-PHKL-LAAGLQCSALLLQ-DTSNLLKRCH------------- 488
            .. ..:.:|.:|        |. ||.: .|.|||...::.| :.:|.:.|..
  Fly   226 CF-APRNSDDIAEVSKLSKQWQIPHLVNNAYGLQAKEIVNQLECANRVGRIDYFVQSSDKNLLVP 289

Human   489 -GSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVE 552
             ||.....|.:...:|||.....: ....:.:|.|...|   :.|..|.....||......||.|
  Fly   290 VGSAIVASFNESVLHDVASTYAGR-ASGSQSLDVLMTLL---SLGRNGFRLLFDQRGENFNYLRE 350

Human   553 EMKK--REGFELVMEPEFVNVCFWFVPPSLRGKQESPDYHERLSKVAPVLKERMVK--------- 606
            .::|  ....|:|::..|.::.......:|.|     |..:.::|:..:|..|.|.
  Fly   351 NLRKFAEPRGEIVIDSRFNSISLAITLATLAG-----DQMKSITKLGSMLHMRGVSGARVIVPGQ 410

Human   607 ----EGSMMIGYQPHGTRGNF---FRVVVANSALTCADMD 639
                :|...:.:..|  |.|.   :..|.|...:|..::|
  Fly   411 NKTIDGHEFLDFGSH--RSNLQVPYLTVAAGIGITREEID 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CSAD	XP_054228176.1	DOPA_deC_like	185..648	CDD:99743	96/515 (19%)
SecS	NP_649556.3	AAT_I	12..457	CDD:450240	109/557 (20%)