Protein Alignment CSAD and CG5618

DIOPT Version :10

• Sequence 1: XP_054228176.1
• Gene: CSAD / 51380
• HGNCID: 18966
• Length: 652
• Species: Homo sapiens
• Sequence 2: NP_649211.1
• Gene: CG5618 / 40241
• FlyBaseID: FBgn0036975
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 573
• Identity: 235/573 - (41%)
• Similarity: 329/573 - (57%)
• Gaps: 92/573 - (16%)

Human    93 REILMADSEALPSLAGDPVAVEALLRAVFGVVVDEAIQKGTSVSQKVCEWKEPEELKQLLDLELR 157
            |:.||.|.:.|.:       |..|||......||.  ||..  .||:..:.:|::||:|::|::|
  Fly    15 RDGLMDDWKILEN-------VFHLLRKEDTFCVDP--QKWD--KQKIVPFLQPDKLKELINLKVR 68

Human   158 -SQGESQKQILERCRAVIRYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFV 221
             ::..|..:|.|.|:.||.|||||.|.||.||||..|||..|||.::||::|.|.||||:||||.
  Fly    69 ETENCSLAEIEELCQQVIHYSVKTSHGRFHNQLFGQLDPFGLAGALVTEAMNGSTYTYEVAPVFS 133

Human   222 LMEEEVLRKLRALVGWSSGDGIFCPGGSISNMYAVNLARYQRYPDCKQRGLRTLPPLALFTSKEV 286
            |:|.||:..:..|.|:..|||||.||||.||||.:.||||:..|:.|..|:..:.||.||||.|
  Fly   134 LIETEVIATICKLAGYKEGDGIFAPGGSTSNMYGMVLARYKIAPEVKTSGMFGMRPLVLFTSDE- 197

Human   287 GKRHRPNPGLLILISSQLSRDLPGLLPALPTSSKASLPPGGCASFQSRSVTTPSRRELRFWDLAP 351
              .|..    .:..::.|                      |..|:...||.|..|.::...||..
  Fly   198 --SHYS----FVKAANWL----------------------GLGSYNCVSVRTNERGQMLLDDLEA 234

Human   352 TVSEWSRLMREGKWSPRIWRGRLVWPRLRLTFHFFETFILDSGAVPFLVSATSGTTVLGAFDPLE 416
            .::|                     .:.|             |..||.|:.|:|||||||||.:.
  Fly   235 KIAE---------------------AKAR-------------GGEPFFVNCTAGTTVLGAFDDIN 265

Human   417 AIADVCQRHGLWLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQDTS 481
            ..|||.:||||||||||..||:.|||..:|.|:.|::||:|.:|||||.:.|.||||..|.:::.
  Fly   266 GAADVTERHGLWLHVDACLGGAALLSAKNRSLIAGLERANSFSWNPHKTIGAPLQCSLFLTRESG 330

Human   482 NLLKRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGDQGLERRIDQAFVL 546
            .||:||:.::|.|||||||||||:.|||:|.|||||::|..|.|||.||:|.......:|.|..:
  Fly   331 RLLERCNSTEAHYLFQQDKFYDVSYDTGNKSVQCGRKIDAFKFWLMLKARGYGKYGLMVDHAIHI 395

Human   547 ARYLVEEMKKR-EGFELVM-EPEFVNVCFWFVPPSLR--GKQESPDYHERLSKVAPVLKERMVKE 607
            ||.|..::::| :.|.||: |.|:.||||||:|.::|  .::|:|::..||..|||.:||:|...
  Fly   396 ARLLEGKLRQRGDRFRLVIPEHEYSNVCFWFIPKAMRVSSEEETPEWWSRLYTVAPKIKEQMAHS 460

Human   608 GSMMIGYQPHGTR--GNFFRVVVANSALTC------ADMDFLLNELERLGQDL 652
            |::||||.|...:  |||||:|     .||      .::||:|:|:||||:.:
  Fly   461 GTLMIGYSPLKAKNLGNFFRMV-----FTCFPILKSKELDFILDEIERLGEKI 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CSAD	XP_054228176.1	DOPA_deC_like	185..648	CDD:99743	198/474 (42%)
CG5618	NP_649211.1	GadA	56..507	CDD:439846	220/518 (42%)