Protein Alignment CSAD and Gad1

DIOPT Version :9

• Sequence 1: XP_024304779.1
• Gene: CSAD / 51380
• HGNCID: 18966
• Length: 620
• Species: Homo sapiens
• Sequence 2: NP_001261396.1
• Gene: Gad1 / 38484
• FlyBaseID: FBgn0004516
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 520
• Identity: 218/520 - (41%)
• Similarity: 323/520 - (62%)
• Gaps: 39/520 - (7%)

Human   105 SLAGDPVAVEALLRAVFGVVVDEAIQKGTSVSQKVCEWKEPEELKQLLDLELRSQGESQKQILER 169
            ::...|...|.||: |..|::| .::.....::||.::..||::|:||||::..:....:|::|.
  Fly    26 TVTAGPETREFLLK-VIDVLLD-FVKATNDRNEKVLDFHHPEDMKRLLDLDVPDRALPLQQLIED 88

Human   170 CRAVIRYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLRKLRAL 234
            |...::|.||||||.|||||.:|||..::||..:|.:.||:.:||||||||:|||..||.|:|.:
  Fly    89 CATTLKYQVKTGHPHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILMENVVLTKMREI 153

Human   235 VGWSSGDGIFCPGGSISNMYAVNLARYQRYPDCKQRGLRTLP-PLALFTSKEVGKRHRPNPGLLI 298
            :|||.||.|..|||||||:||...||::.:|:.|:.|...|| .|.:|||.:.....:....:..
  Fly   154 IGWSGGDSILAPGGSISNLYAFLAARHKMFPNYKEHGSVGLPGTLVMFTSDQCHYSIKSCAAVCG 218

Human   299 LISSH-VTTPSRRELRFWDLAPTVSEWSRLMREGKWSPRIWRGRLVWPRLRLTFHFFETFILDSG 362
            |.:.| :..||....:.     ..||..||:.|.|                           ..|
  Fly   219 LGTDHCIVVPSDEHGKM-----ITSELERLILERK---------------------------AKG 251

Human   363 AVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVLLSQTHRH-LLDGIQRADSV 426
            .:||.|:||:|||||||||.:..|||:||::..|:|:||||||.:|:|:.||| ...|::|||||
  Fly   252 DIPFFVNATAGTTVLGAFDDINTIADICQKYNCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSV 316

Human   427 AWNPHKLLAAGLQCSALLLQDTSNLLKRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLK 491
            .||||||:.|.||||.:..:: ..||..|:...|.|||..||.||::.||||||:||||..|..|
  Fly   317 TWNPHKLMGALLQCSTIHFKE-DGLLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFK 380

Human   492 LWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKR-EGFELVMEPEFVNVCFWFVPPSLRGKQESP 555
            |||.|:|:|.:|.|::.|:...|.:|.::.:::: :.|.|::|||.|||.||:||..|||.....
  Fly   381 LWLQWRAKGTEGFEQQQDRLMELVQYQLKRIREQSDRFHLILEPECVNVSFWYVPKRLRGVPHDA 445

Human   556 DYHERLSKVAPVLKERMVKEGSMMIGYQPHGTRGNFFRVVVANSALTCADMDFLLNELERLGQDL 620
            .....|.|:.|::|.||:::|::|:||||...|.||||.:::::|:..||:||:|:|:.|||.||
  Fly   446 KKEVELGKICPIIKGRMMQKGTLMVGYQPDDRRPNFFRSIISSAAVNEADVDFMLDEIHRLGDDL 510

Human   621  620
              Fly   511  510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CSAD	XP_024304779.1	DOPA_deC_like	185..616	CDD:99743	187/434 (43%)
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	175/402 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730