Protein Alignment Atp8a2 and CG33298

DIOPT Version :10

• Sequence 1: NP_056618.1
• Gene: Atp8a2 / 50769
• MGIID: 1354710
• Length: 1148
• Species: Mus musculus
• Sequence 2: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Alignment Length: 1306
• Identity: 418/1306 - (32%)
• Similarity: 634/1306 - (48%)
• Gaps: 266/1306 - (20%)

Mouse     6 SVGDQLEAPA-RIIYLN---------QSHLN-KFCDNRISTAKYSVLTFLPRFLYEQIRRAANAF 59
            :.||:.|..: |.:..|         :.|.| :|..|:|.|.||::|:|:|:.|.||..|.||.:
  Fly   217 NTGDKFEERSYRTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLY 281

Mouse    60 FLFIALLQQIPDVSPTGRYTTLVPLVIILTIAGIKEIIEDFKRHKADNAVNKKKTIVLRNG---M 121
            |:||.||..:|::|..|:...::|::.:|.:..:|::.||.:|..:|..:| ..|..:.:|   .
  Fly   282 FIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRIN-NTTCRVYDGETER 345

Mouse   122 WHTIMWKEVAVGDIVKVLNGQYLPADMVLFSSSEPQGMCYVETANLDGETNLKIRQGLSHTTDMQ 186
            :..:.|:|:.|||||.:.|.:.:|||::|..:|:|||:||::|.:||||||||.|:.:....:||
  Fly   346 YKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQ 410

Mouse   187 TRDVLMKLSGRIECEGPNRHLYDFTGNL-HLDGKSSVALGPDQILLRGTQLRNTQWVFGVVVYTG 250
            :..|..|...|:|.:.|...||.|.|.| |..|: .|.:..:.:|||.::|:||.::.|:|||.|
  Fly   411 SIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGE-RVPISTECLLLRESRLKNTDYIEGIVVYAG 474

Mouse   251 HDSKLMQNSTKAPLKRSNVEKVTNVQILVLFGILLVMALVSSVGALFWNGS--HGGKSWYI--KK 311
            |::|.|.|::....|||.||:..|:.::....|||::.:|.::|...|..|  |.... |:  .|
  Fly   475 HETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPVP-YLPPNK 538

Mouse   312 MDTNSDNFGYNLLTFIILYNNLIPISLLVTLEVVKYTQALFINWDMDMYYIENDTPAMARTSNLN 376
            :..|.::. :...|:|::...:||:||.||:|:.|..|...|:.::|::..|.:.....|..|:.
  Fly   539 LTANMESM-WIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNIT 602

Mouse   377 EELGQVKYLFSDKTGTLTCNIMNFKKCSIAGVTYGHFP-ELAREQSSDDFCRMTSCTNDSCDFND 440
            |||||::::|:|||||||.|.|.|::|.:.|..|.|.| ||.:..|...........||:.: :|
  Fly   603 EELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDNLN-SD 666

Mouse   441 PRLLKNIEDQHPTAPCIQEFLTLLAVCHTVV----PEKD-------------------------- 475
            ...|.......|.|..|||||.:||:|:||:    |.:|
  Fly   667 MAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQR 731

Mouse   476 ------------------------------GDEII------------------------------ 480
                                          .|..|
  Fly   732 QKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLS 796

Mouse   481 ----------------------------------------------------------------- 480
                                                                             
  Fly   797 PISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSS 861

Mouse   481 --------------YQASSPDEAALVKGAKKLGFVFTGRTPYSVIIE--AMGQEQTFGILNVLEF 529
                          |:|.||||.|||..|.........|:|..:::.  ..|..:.:.||.||.|
  Fly   862 KTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPF 926

Mouse   530 SSDRKRMSVIVR-LPSGQLRLYCKGADNVIFERL------SKDSKYMEETLCHLEYFATEGLRTL 587
            .|.||.||::|| :.|.::.||.||||:.|...|      |.:....|:|...|:.:|.||||.|
  Fly   927 DSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLRIL 991

Mouse   588 CVAYADLSENEYEEWLKVYQEASIILKDRAQRLEECYEIIEKNLLLLGATAIEDRLQAGVPETIA 652
            .:|...|:..:|.:|...:||..:.|::|.:||.:.:..:|.||.|||||.||||||.|||||||
  Fly   992 VMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIA 1056

Mouse   653 TLLKAEIKIWVLTGDKQETAINIGYSCRLVSQNMALILLKEDSLDATRAAITQHCTDLGN----- 712
            :||.|.|.:|||||||.||||||.||.:|.:|.|.||.|...|.||...||..:.||:.|
  Fly  1057 SLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTDMENDKTTS 1121

Mouse   713 LLG-----KENDVALIIDGHTLKYAL--SFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKK 770
            .||     ::...||::||.||.:.|  ..::...||.|:..|.:|:|||.:||||:.:|.|||:
  Fly  1122 TLGYGQSLRKKQRALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKE 1186

Mouse   771 RVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFSYLEKLLLVHGAWSYNRV 835
            .:...|||||||||||.|||.|.|||||||.|||||...:|:.:.:|.|||:|||.||.|.|:|:
  Fly  1187 ELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRL 1251

Mouse   836 TKCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESM 900
            ::.|||.||||.....:..|:....|||||::.::..:.|||:|||:|||..:|::::...::.:
  Fly  1252 SRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLL 1316

Mouse   901 LRFPQLYRITQNAEGFNTKVFWGHCINALVHSLILFWVPMKA-LEHDTPVTSGHATDYLFVGNIV 964
            |:.|.||:..:....:....||...::||..||::|:|.:.| .|.|             ||...
  Fly  1317 LKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYAESD-------------VGIWE 1368

Mouse   965 YTYVVVTVCLKAGL-----ETTAWTKFSHLAV---WGSMLIWLVF--------FGVYSTIWPTIP 1013
            :...:...||.|.|     |..:||....|::   .||..::.:.        |||.|:.|...
  Fly  1369 FGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIF- 1432

Mouse  1014 IAPDMKGQATMVLSSAYFWLGLFL-----VPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRV 1073
                      :..:||..||.:.|     |....|:..|..........|.:|:..:|     |.
  Fly  1433 ----------VCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKVILQSKRE-----RS 1482

Mouse  1074 MGKAML 1079
            .|:|:|
  Fly  1483 RGEALL 1488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atp8a2	NP_056618.1	ATPase-Plipid	28..1066	CDD:273734	406/1258 (32%)
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	374/1107 (34%)